A kind of synthetic method of morpholine amididine hydrochloride

Abstract

The invention discloses a synthetic method of moroxydine hydrochlofide. The method comprises the following steps: adding diglycol, dicyandiamide, ammonium chloride and an aqueous sulfuric acid solution with the mass concentration of 20-30% to a high pressure reaction kettle according to amass ratio of (4-6):(4-6):(2-4):(1-2), heating the obtained solution in a sealed and stirring state to 120-130DEG C, reacting under a reaction kettle pressure of 0.3-0.5MPa for 1-2h, and cooling the obtained solution to room temperature to obtain a white milk; and transferring the white milk to a reaction kettle, adding 95% ethanol according to a volume ratio of the 95% ethanol to diglycol of (7-9):1, carrying out a heating refluxing reaction for 30min to obtain a mixed solution, carrying out hot filtration on the mixed solution through a filter cylinder to a crystallization kettle, cooling the obtained filtrate in the crystallization kettle to room temperature to precipitate white crystals, centrifuging and separating the white crystals, and drying the separated white crystals in a hot wind oven at 80-85DEG C to obtain moroxydine hydrochlofide.. Moroxydine hydrochlofide is obtained through a direct reaction of dicyandiamide and morpholine hydrochloride generated through in situ reaction of diglycol and ammonium chloride under the action of sulfuric acid, so the synthetic method is simplified, side reactions are reduced, the yield is improved, and environment is protected.

Description

technical field

[0001] The invention relates to the field of organic synthesis, in particular to a method for synthesizing morpholine amididine hydrochloride. Background technique

[0002] Morpholine guanidine, also known as morpholine guanidine, commonly known as "viral spirit", as an antiviral chemical raw material drug, can inhibit the reproduction of certain viruses in cells. It is mainly used for the prevention and treatment of viral influenza, mumps, chickenpox, herpes zoster, herpetic stomatitis and other viral diseases. It can also be used in animal husbandry, aquatic products and pesticide industries. It has a wide range of uses. When used as a drug, the compound is usually produced in the form of morpholine amidine hydrochloride, which can inhibit the reproduction of viruses by inhibiting the synthesis of DNA and RNA polymerases of certain viruses in cells, including influenza A H1N1, influenza virus, para Influenza virus, coronavirus, rhinovirus, adenovirus, etc....

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