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Preparation method of core-shell structure collagen polypeptide chelated calcium nanoparticle

A technology of collagen peptides and nanoparticles, applied in medical preparations with non-active ingredients, medical preparations containing active ingredients, drug combinations, etc., can solve the problems of complicated preparation methods and large capsule size, and ensure absorption and utilization , easy to absorb, overcome the effect of easy enzymatic hydrolysis

Active Publication Date: 2012-04-25
THIRD INST OF OCEANOGRAPHY STATE OCEANIC ADMINISTATION
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, there are many methods of using alginate to embed drugs, but the preparation methods are relatively complicated, and most of them inevitably use emulsifiers or special equipment in two phases, and the prepared capsules are relatively large in size, mostly in the micron range.

Method used

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  • Preparation method of core-shell structure collagen polypeptide chelated calcium nanoparticle

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] Take 15ml of 0.03g / ml collagen peptide chelated calcium aqueous solution and slowly add to 7.5ml of 0.018mol / L CaCl 2 In the aqueous solution, stir evenly and fully, adjust the pH to 7.2 to obtain solution A; take 117.5mL 0.63g / L sodium alginate solution, adjust the pH to 7.2, then slowly add solution A dropwise, and keep stirring throughout the process to make it fully reacted. After the solution A is added, the stirring is continued for 30-60 minutes to obtain calcium alginate / collagen polypeptide chelated calcium nanoparticles with core-shell structure. The prepared calcium alginate / collagen polypeptide chelated calcium nanoparticles with a core-shell structure are spherical nanoparticles with a smooth surface, and the particle diameter ranges from 200 to 1000 nm.

[0021] figure 1 The transmission electron microscope image of the prepared core-shell structure collagen polypeptide chelated calcium nanoparticles is given. The sample particle size in the figure is abo...

Embodiment 2

[0023] Take 15ml of 0.1g / ml collagen polypeptide chelated calcium solution and slowly add to 7.5ml of 0.072mol / L CaCl 2 In the aqueous solution, stir evenly and fully, and adjust the pH to 6.0 to obtain solution A; take 117.5mL of 0.63g / L sodium alginate solution, adjust the pH to 6.0, then slowly add solution A dropwise, and keep stirring throughout the process to make it fully reacted. After the solution A is added, the stirring is continued for 30-60 minutes to obtain the core-shell structure collagen polypeptide chelated calcium nanoparticles with a particle diameter ranging from 400-1000 nm.

Embodiment 3

[0025] Take 15ml of 0.05g / ml collagen peptide chelated calcium aqueous solution and slowly add to 10ml of 0.020mol / L BaCl 2 In the aqueous solution, stir evenly and fully, adjust the pH to 7.5 to obtain solution A; take 117.5mL of 1.0g / L sodium alginate solution, adjust the pH to 7.5, then slowly add solution A dropwise, and keep stirring throughout the process to make it fully reacted. After the solution A is added, the stirring is continued for 30-60 minutes to obtain the core-shell structure collagen polypeptide chelated calcium nanoparticles with a particle size ranging from 200-800 nm.

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Abstract

A preparation method of a core-shell structure collagen polypeptide chelated calcium nanoparticle relates to a preparation method of a nanometer calcium supplementing product. A preparation method of a core-shell structure collagen polypeptide chelated calcium nanoparticle is provided which does not require special equipment and is simple in operation. Soluble alginates are dissolved in water to obtain an alginate solution with a concentration of 0.1-2.0 g / L; a soluble bivalent cation aqueous solution A is prepared with a concentration of 0.01-0.1 mol / L; a collagen polypeptide chelated calcium aqueous solution is prepared with a concentration of 0.01-0.1 mol / L; the collagen polypeptide chelated calcium aqueous solution is added into the solution A, and the pH is adjusted to 5.5-8.0 so as to obtain a solution B; the pH of the alginate solution is adjusted to 5.5-8.0, and the solution B is added and stirred to obtain the core-shell structure collagen polypeptide chelated calcium nanoparticle.

Description

technical field [0001] The invention relates to a preparation method of a nano calcium supplement product, in particular to a preparation method of a core-shell structure collagen polypeptide chelated calcium nanoparticle. Background technique [0002] Alginic acid is a block linear polymer composed of two monomers, guluronic acid (G) and mannuronic acid (M), which can be combined with divalent cations to form a gel. The raw material for the production of alginate is kelp and other macroalgae, which is an important part of my country's marine aquatic resources and an important economic algae for large-scale farming in my country. Alginate is biodegradable, and the degradation products are non-toxic, so it can be used as the skeleton and microcapsule material of sustained-release preparations. As a capsule material, alginate has the advantages of stability, hydrophilicity, solubility, non-toxicity, non-irritation and reasonable drug release rate. [0003] At present, there ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/14A61K38/39A61K47/36A61P3/14
Inventor 郭洪辉易瑞灶
Owner THIRD INST OF OCEANOGRAPHY STATE OCEANIC ADMINISTATION
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