54 results about "Urea nitrogen" patented technology

The invention discloses a xanthine oxidase inhibitory peptide with a kidney improving function and application thereof, and belongs to the technical field of biological medicines.The xanthine oxidase inhibitory peptide is screened out by conducting enzymolysis, separation and purification on litopenaeus vannamei processing by-products and utilizing a molecular docking technology, the amino acid sequence of the xanthine oxidase inhibitory peptide is Pro-Leu-Gly-Pro-Pro-Pro, and the amino acid sequence of the xanthine oxidase inhibitory peptide is Pro-Leu-Gly-Pro-Pro-Pro. And the half inhibition concentration of the polypeptide is 2.356 + / -0.2448 mM. The xanthine oxidase inhibitory peptide is proved to have an improvement effect on hyperuricemia mice, the improvement effect is mainly characterized by reducing the content of serum uric acid, creatinine and urea nitrogen of the hyperuricemia mice, inhibiting the activity of xanthine oxidase (XOD) in serum and livers of the mice, inhibiting synthesis of uric acid and improving kidney injury of the mice, and Toxinpred prediction shows that the xanthine oxidase inhibitory peptide has the effect of inhibiting the activity of xanthine oxidase (XOD) in the serum and livers of the mice. The xanthine oxidase inhibitory peptide is free of toxic and side effects, so that the xanthine oxidase inhibitory peptide has a wide application prospect in preparation of food or drugs for improving renal functions.

The invention discloses a xanthine oxidase inhibitory peptide with uric acid reducing activity and application thereof, and belongs to the technical field of biological medicines.The xanthine oxidase inhibitory peptide is obtained by conducting enzymolysis, separation and purification on processing byproducts such as litopenaeus vannamei heads and shells with xanthine oxidase inhibitory activity. The xanthine oxidase inhibitory peptide is screened by using a molecular docking technology, and the amino acid sequence of the xanthine oxidase inhibitory peptide is Pro-Pro-Val-Pro-Pro-Pro. The xanthine oxidase inhibitory peptide has an XOD (X-Oxidase) half inhibitory concentration of 3.181 + / -0.1786 mM. The invention further proves that the xanthine oxidase inhibitory peptide has a certain improvement effect on hyperuricemia mice, and the xanthine oxidase inhibitory peptide mainly has the effects of reducing the content of serum uric acid, creatinine and urea nitrogen of the hyperuricemia mice, inhibiting the activity of xanthine oxidase (XOD) in serum and liver of the mice, inhibiting synthesis of uric acid and improving kidney injury of the mice, and the xanthine oxidase inhibitory peptide has a certain improvement effect on the hyperuricemia mice through Toxinpred prediction. The xanthine oxidase inhibitory peptide uric acid reducing peptide is free of toxic and side effects and has a wide market application prospect.

The invention discloses an intestinal strain capable of effectively regulating uric acid metabolism, a microbial agent of the intestinal strain and application of the intestinal strain in uric acid reducing products, and belongs to the technical field of microorganisms. According to the enterococcus pluvialis ZQ205, the enterococcus pluvialis ZQ205 which is free of toxic and side effects and capable of effectively relieving and treating the hyperuricemia is found for the first time, and the collection number of the enterococcus pluvialis ZQ205 in the China Center for Type Culture Collection is CCTCC NO: M 2025844; the strain can significantly reduce the levels of uric acid, creatinine and urea nitrogen in serum of mice, can effectively reduce the levels of inflammatory factors such as IL-6 and TNF-alpha in serum of hyperuricemia mice, and can improve kidney injury caused by hyperuricemia.

The invention discloses a fungus extract capable of effectively regulating uric acid metabolism and relieving inflammation as well as a preparation method and application of the fungus extract, and belongs to the technical field of deep processing of edible fungi. Schizophyllumcommuneh and poplar phellinus sporocarp are mixed and extracted, and the prepared fungus extract can effectively inhibit activity of xanthine oxidase in serum and liver of mice, reduce content of uric acid, creatinine, urea nitrogen and the like in serum and promote excretion of uric acid, creatinine, urea nitrogen and the like in urine; meanwhile, the content of inflammatory markers such as IL-6 and TNF-alpha in mouse serum can be effectively reduced, inflammatory infiltration of liver and kidney cells is relieved, and the problem that an existing edible mushroom extract is not ideal in treatment effect on hyperuricemia is solved.

The present invention relates to a uric acid-lowering probiotic complex and its application. The probiotic complex comprises Lactobacillus reuteri FPH2951 and Bifidobacterium breve FPHC4024; wherein Lactobacillus reuteri FPH2951 is classified as Lactobacillus reuteri and has a deposit number of GDMCC No. 62946; and Bifidobacterium breve FPHC4024 is classified as Bifidobacterium breve and has a deposit number of GDMCC No. 62945. The probiotic complex of the present invention can significantly reduce serum uric acid (UA), creatinine (Cr), and blood urea nitrogen (BUN) levels and increase urine excretion of creatinine (Cr) and blood urea nitrogen (BUN) through the synergistic effect of Lactobacillus reuteri FPH2951 and Bifidobacterium breve FPHC4024, and has broad application prospects.

The invention relates to application of bacillus coagulans BC99 in preparation of a probiotic preparation for assisting in reducing the uric acid level. The bacillus coagulans BC99 is a bacillus coagulans BC99 strain of which the preservation number is CGMCC (China General Microbiological Culture Collection Center) No. 21801, and the bacillus coagulans BC99 strain of which the preservation number is CGMCC No. 21801. The invention finds that the bacillus coagulans BC99 has a very remarkable effect in the aspect of assisting in reducing uric acid, and the effect is specifically shown as follows: the levels of serum uric acid, urea nitrogen and creatinine of a hyperuricemia rat are reduced; the xanthine oxidase activity of the hyperuricemia rats is improved; the serum inflammatory factor level of the hyperuricemia rats is regulated, and the inflammatory reaction caused by uric acid increase is inhibited; and the levels of glutamic oxalacetic transaminase and glutamic-pyruvic transaminase of high-uric-acid rats Meanwhile, the bacillus coagulans BC99 is used as a probiotic, so that the product is high in safety and not easy to generate resistance.

The invention provides a combined lactobacillus salivarius YS-UR90 and a preparation method of the combined lactobacillus salivarius YS-UR90. The saliva combined lactobacillus provided by the invention can secrete protease and glycosidase, and the HCT and FLS gene expression levels of the saliva combined lactobacillus are high, so that the saliva combined lactobacillus can promote phenolic acid active ingredients to generate biotransformation during fermentation, and the proportion of chlorogenic acid and the like in fermentation liquor is increased. For example, marine fish oligopeptide and casein phosphopeptides are used as a composite nitrogen source, dandelion powder is used as a functional substrate, and a composite fermentation product obtained through fermentation of saliva and lactobacillus has the effect of promoting uric acid excretion and has a certain protection effect on kidney injury. The compound fermentation product has the effect of improving hyperuricemia mainly by inhibiting XOD activity, increasing serum urea nitrogen level, improving defect expression of uric acid synthesis gene HPRT1, inhibiting expression of uric acid reabsorption URAT1 and GLUT9 genes and improving expression of excretion genes OAT1 and ABCG2.

The invention provides a high-sensitivity ammonia gas sensor for early chronic kidney disease diagnosis and uremia dialysis curative effect monitoring, and relates to the field of exhaled gas analysis of diseases. The preparation method of the gas sensor comprises the following steps: S1, preparing I n2O3 nanofibers by an electrostatic spinning method; s2, the collected eggshell membranes are treated and cleaned so as to be used for a flexible substrate; and S3, growing an aniline monomer and the In2O3 nanofibers on the surface of the eggshell membrane in an in-situ chemical oxidation polymerization manner to prepare the polyaniline composite In2O3 nanofiber flexible film based on the eggshell membrane as the substrate. According to the method, the concentration difference of NH3 and creatinine in exhaled gas of a patient and a healthy person is analyzed, painless early diagnosis of the chronic kidney disease is achieved, the dialysis process is monitored painlessly and the curative effect is evaluated by analyzing the change of the concentration of NH3 in exhaled gas of a uremia patient in the dialysis process, and meanwhile the result is obtained through clinical tests. The response value of the sensor to exhaled gas has a good linear relationship with clinical indexes of creatinine and blood urea nitrogen representing the content of in-vivo metabolic nitrogen waste.

The present invention discloses a uric acid-lowering functional peptide composition and its product, belonging to the technical field of functional peptides. The functional peptide composition provided by the present invention has the effect of significantly reducing the uric acid content and xanthine oxidase in the blood, and can reduce the content of creatinine and urea nitrogen in the blood, improve kidney health, and promote the excretion of excess uric acid; each component of the functional peptide composition provided is safe and has no toxic side effects, and the main component is the purslane polypeptide extract derived from the health-preserving wild vegetable-purslane, without hormone and pesticide residue hidden dangers, and the preparation process adopts low temperature, high temperature, isoelectric point to denature and precipitate the protein, and the pectinase and flavor protease used in the preparation process are enzymes originally present in plants, and no toxic and harmful organic solvents are used, and the prepared functional peptides are highly safe and have no toxic side effects.

The invention provides an application of ACR11 protein in improving the content of plant protein and the utilization efficiency of urea, and provides an application of the ACR11 protein in improving the yield of the plant protein and / or improving the utilization efficiency of the plant to a urea nitrogen fertilizer, and the ACR11 protein can improve the yield of the plant protein and improve the utilization efficiency of the plant to the urea nitrogen fertilizer. The ACR11 protein disclosed by the invention can also improve the utilization efficiency of a plant on urea nitrogen fertilizer, and is specifically characterized in that a transgenic plant formed by transferring the coding gene of the duckweed ACR11 protein disclosed by the invention into a receptor plant is cultured under the condition of taking urea as a nitrogen source; compared with a receptor plant cultured under the same condition, the transgenic plant has higher biomass, higher protein content, higher protein yield and higher protein production efficiency under the same urea nitrogen fertilizer input. The invention provides a new way for improving the utilization efficiency of urea by crops and improving the protein yield of the crops in agriculture, and is beneficial to promoting the sustainable development of green agriculture.

According to the medicine and food homologous composition and the preparation method and application thereof, in a hypoxia fatigue swimming experiment, the composition can reduce lactic acid accumulation, uric acid and urea nitrogen generation and exert the hypoxia and fatigue resisting effect, and it is proved through a hypoxia pulmonary vascular injury mouse model that the composition can reduce inflammatory response and regulate vascular homeostasis, and the anti-hypoxia and anti-fatigue effects are achieved. Therefore, the medicinal and edible composition can be used for preparing functional foods, health care products or medicines for resisting hypoxia fatigue and hypoxia pulmonary vascular injury.

The invention discloses a walnut-derived xanthine oxidase inhibitory peptide and application thereof, and belongs to the technical field of bioactive peptide biology. The amino acid sequence of the xanthine oxidase inhibitory peptide provided by the invention is as shown in SEQ ID No. 1. Through in-vitro activity determination, the IC50 value of the inhibitory peptide is 3.34 mg / mL, and it is proved that the inhibitory peptide has high inhibitory activity on xanthine oxidase. Besides, the inhibitory peptide can reduce the levels of creatinine, urea nitrogen, adenosine deaminase, glutamic oxalacetic transaminase and glutamic-pyruvic transaminase, regulate the expression of kidney uric acid resorption protein URAT1, uric acid excretion protein GLUT9 and ABCG2, and significantly reduce the generation of uric acid, can be used for inhibiting xanthine oxidase and preventing or improving hyperuricemia, is applied to preparation of drugs for improving hyperuricemia, and has broad application prospects. The medicine takes the active peptide as the only active ingredient or one of the active ingredients, and has a good application prospect.

The invention provides lactobacillus reuteri and an application thereof. The lactobacillus reuteri provided by the invention has a preservation number of CGMCC (China General Microbiological Culture Collection Center) NO. 32834 in the General Microbiological Culture Collection Center of the China Committee for Culture Collection of Microorganisms. The lactobacillus reuteri provided by the invention can inhibit the activity of xanthine oxidase, promote the degradation of creatinine and guanosine, remarkably reduce the content of blood uric acid, reduce the content of creatinine and urea nitrogen, slow down tissue damage caused by hyperuricemia, improve the health level of damaged tissues caused by hyperuricemia, and improve the quality of the tissue damaged by hyperuricemia. Meanwhile, the probiotics have multiple beneficial effects in the aspects of eliminating inflammation, enhancing the immune function and the like, and the problem that existing uric acid reducing probiotics are insufficient in effectiveness is solved. The application can be used for developing microecological preparations, functional foods or nutritional supplements which are mainly used for reducing uric acid and have multiple effects (one bacterium has multiple purposes), and has a good industrialization prospect.

The invention discloses a composition for synergistically relieving physical fatigue and application thereof. The composition disclosed by the invention can synergistically regulate oxidation resistance, calcium ion metabolism and energy metabolism, synergistically improve the ATP content and glycogen level of an organism, accelerate removal of lactic acid and urea nitrogen, prolong exercise time and remarkably relieve physical fatigue, and the synergistic effect of the composition is better than that of single use of red ginseng, lycium ruthenicum and lucid ganoderma. Meanwhile, the components of the composition disclosed by the invention are simple and are all from natural plants; meanwhile, through scientific argumentation and test verification, the action mechanism of the composition is clear, the fatigue relieving interaction relationship among the components is clear, and the composition has the advantages of being green and safe. In addition, the composition disclosed by the invention is simple in preparation process, convenient to operate, low in production cost and convenient to realize industrial development, and professional technicians and large-scale instruments and equipment do not need to be invested.

The present invention discloses the combined use of scopolamine and hyoscyamine in the preparation of a drug for preventing or / and treating hyperuricemia. The combined use has an excellent synergistic effect, can significantly reduce the levels of serum uric acid, creatinine, and urea nitrogen, reduce the reabsorption of uric acid, creatinine, and urea nitrogen in urine by the kidney, and promote the excretion of the three, has significant anti-hyperuricemia activity, and has a protective effect on the kidney; it can also significantly reduce the generation of inflammatory factors, effectively improve the symptoms of joint swelling in gouty arthritis, and has clinical application value and development prospects.

1. Name of the designed product: packing bag (containing phosphorus urea nitrogen). 2. Use of the designed product: used for packing bag of fertilizer. 3. Design points of the designed product: combination of shape and pattern. 4. Picture or photo showing the design points: front view. 5. The designed product is a thin product, and other views are omitted.

Provided in the invention is a stabilized fertilizer composition (I) suitable for use in fertilizers and comprising: Urea (a), One or more compounds (b), One or more urease inhibitors (c1) and / or one or more nitrification inhibitors (c2), optionally provided in one or more carriers (d), said compounds (c) being different from compounds (b), Optionally one or more additives (e) different from any of the above, and Water (f) in an amount less than about 10 wt % and preferably less than about 5 wt %; wherein compounds (b) are selected from thiosulfates (b1) and / or from polysulfides (b2) and / or from (bi)sulfites (b3); and wherein the ratio of urea (a) to compounds (b) is from 1:99 to 99:1, preferably from 2:98 to 98:2. Products of the invention can be made in various forms and in different ways. All of the materials of the invention are suitable for use in fertilizers and blend well with solid and liquid fertilizers standardly used. They have excellent shelf life and provide good urea-N protection.

Provided is use of kynurenic acid in resisting hyperuricemia and a structural analog thereof in preparing an XOD inhibitor, wherein kynurenic acid and the structural analog have good inhibitory activity on xanthine oxidase (XOD). Kynurenic acid has no significant influence on the growth and body weight of mice, and the oral administration of kynurenic acid at a low dose, medium dose, or high dose can significantly reduce the serum levels of creatinine and blood urea nitrogen in mice and effectively inhibit the activity of XOD in the liver of mice, thus reducing the level of uric acid in the livers in a concentration-dependent manner. Kynurenic acid, whether administered at a low dose, medium, or high dose, can effectively reduce the enzymatic activity of adenosine deaminase (ADA) in the serum of mice with hyperuricemia and limit the generation of uric acid precursors. Therefore, kynurenic acid can be used as a medicament for alleviating or treating hyperuricemia.

The invention belongs to the technical field of fertilizers, and particularly relates to PBAT-based environment-friendly slow-release coated urea and a preparation method thereof. The PBAT-based environment-friendly slow-release coated urea provided by the invention comprises urea particles and a coating layer coating the urea particles, and the coating layer comprises the following raw materials: PBAT, an organic matter modifier and an inorganic matter modifier; the organic matter modifier comprises at least one of methyl cellulose or polyvinyl ether, and the inorganic matter modifier comprises at least one of bentonite or hydrotalcite. The coating material used in the PBAT-based environment-friendly slow-release coated urea has good biodegradability, degradation products have little harm to soil, the time required for the nitrogen nutrient release amount of the PBAT-based environment-friendly slow-release coated urea to reach 90% is 80-120 days, and the PBAT-based environment-friendly slow-release coated urea is suitable for growth of crops such as corn, soybeans and rice.

The present application discloses a water sample pretreatment reagent, a total nitrogen detection kit and a detection method for the detection of total nitrogen in water bodies. The water sample pretreatment reagent includes reagent A, reagent B and reagent C; reagent A is a nitrogen fixation alloy; reagent B is a urease extract; reagent C is a sodium potassium tartrate-sodium hydroxide solution; the preparation of the urease extract includes: mixing a stabilizer and glycerol, then adding soybean powder, stirring and extracting at room temperature, taking the supernatant and filtering, and taking the filtrate. The total nitrogen detection kit includes an ammonia nitrogen detection reagent and a pretreatment reagent. The detection method includes: taking a detection water sample, adding reagent A and mixing evenly, then adding reagent B and mixing evenly, carrying out an enzymatic hydrolysis reaction for 4 to 6 minutes, finally adding reagent C, mixing evenly and reacting to obtain a pretreatment solution, adding an ammonia nitrogen detection reagent to the pretreatment solution, and detecting after color development. The present application can measure the sum of urea nitrogen and inorganic total nitrogen in water bodies, and is particularly suitable for the determination of total nitrogen in swimming pool water and the determination of total nitrogen in relevant river channels of farmland where urea is applied.

The invention provides an application of a paederia scandens extract PSMF rich in flavonoid compounds in preparation of a product for reducing uric acid. Animal experiment research finds that the PSMF intervenes and relieves weight loss and food intake reduction of a mouse with hyperuricemia, and meanwhile, the decrease of liver and kidney indexes is reversed. In addition, the PSMF also significantly reduces the levels of serum uric acid, xanthine oxidase, adenosine deaminase, creatinine, blood urea nitrogen and the like of hyperuricemia mice, inhibits inflammatory response, and protects liver and kidney injury. And finally, the PSMF improves in-vivo uric acid homeostasis by regulating the expression of the uric acid synthesis gene and the uric acid transporter gene. Results show that PSMF intervention has an effect of regulating uric acid homeostasis, has a good treatment effect on hyperuricemia, and is expected to be used as a natural dietary supplement for treating and preventing hyperuricemia.

One embodiment of a blood urea nitrogen (BUN) sensor measures urea nitrogen in a biological sample by measuring a differential voltage signal based on first and second voltage signals each representing a detected amount of carbon dioxide. The first signal represents a detected amount of carbon dioxide resulting from an enzymatic reaction of a biological sample contacting a sensor surface having a urease enzyme immobilized thereon. The second voltage signal represents a detected amount of background carbon dioxide in the biological sample. The differential voltage signal indicates an amount of urea nitrogen in the biological sample, which may be determined by appropriate correlation. Other embodiments of BUN sensors and methods of sensing BUN are also provided, as are other aspects.

Nitrogen is one of the primary nutrients essential to all forms of life. However, only a few plant species can live in a symbiotic relationship with nitrogen-fixing bacteria and nitrogen must first be converted to a form that plants can utilize. Accordingly, aspects of the present disclosure relate to providing nitrogen fixation to cereal plants using genetically engineered bacteria. In some embodiments, genetically engineered bacteria comprise engineered nucleic acids encoding one or more urea metabolism regulators and / or effect the activity of one or more urea metabolism regulators. In some embodiments, the genetically engineered bacterium release more extracellular urea compared to wildtype counterparts. In some embodiments, extracellular urea is ultimately broken down into ammonia and carbon dioxide which are subsequently used by a plant cell to produce amino acids and glucose, respectively.

The invention relates to a probiotic compound capable of reducing uric acid and application of the probiotic compound. The probiotic compound comprises lactobacillus reuteri FPH2951 and bifidobacterium breve FPHC4024. Wherein the lactobacillus reuteri FPH2951 is classified and named as lactobacillus reuteri, and the preservation number of the lactobacillus reuteri FPH2951 is GDMCC NO.62946; the bifidobacterium breve FPHC4024 is classified and named as bifidobacterium breve, and the preservation number of the bifidobacterium breve FPHC4024 is GDMCC NO.62945. The invention further discloses a preparation method of the bifidobacterium breve FPHC4024. According to the probiotic compound, through the synergistic effect of the lactobacillus reuteri FPH2951 and the bifidobacterium breve FPHC4024, the levels of uric acid (UA), creatinine (Cr) and urea nitrogen (BUN) in serum can be remarkably reduced, the excretion amount of the creatinine (Cr) and the urea nitrogen (BUN) in urine is increased, and the probiotic compound has a wide application prospect.

One embodiment of a blood urea nitrogen (BUN) sensor measures urea nitrogen in a biological sample by measuring a differential voltage signal based on first and second voltage signals, the first and second voltage signals each representing a detected amount of carbon dioxide. The first signal represents a detected amount of carbon dioxide resulting from an enzymatic reaction of a biological sample contacting a sensor surface having urease immobilized thereon. The second voltage signal represents a detected amount of background carbon dioxide in the biological sample. The differential voltage signal is indicative of the amount of urea nitrogen in the biological sample, which can be determined by an appropriate correlation. Other embodiments of a BUN sensor and a method of sensing a BUN are also provided, as are other aspects.

The invention discloses an application of allicin in promoting urea nitrogen to be converted into a nitrogen element in nucleotide or amino acid. Experiments show that the plant source compound allicin has the effect of promoting rumen urea nitrogen to be converted into nitrogen in nucleotide, sugar nucleotide or amino acid; when the garlicin is directly fed to ruminants or added as a feed additive into basic ration of the ruminants to feed the ruminants, urea nitrogen in feed can be promoted to be converted into nitrogen elements in nucleotide, sugar nucleotide or amino acid; the invention further provides a non-therapeutic method for promoting the ruminant to convert urea nitrogen into nitrogen in nucleotides, sugar nucleotides or amino acids, comprising feeding the ruminant with allicin directly or as a feed additive. The method has application prospects in the aspects of providing high-quality protein sources for livestock and poultry, reducing feed cost, improving livestock and poultry production performance and the like.

The invention provides a pharmaceutical composition for preventing, treating or relieving uric acid metabolic disorder and application, the pharmaceutical composition comprises a xanthine oxidase inhibitor and a URAT1 inhibitor, and the xanthine oxidase inhibitor is selected from teguxostat or febuxostat; the URAT1 inhibitor is selected from the group consisting of dotenod, Velnod, Lesinurad, Ruzinurad, SAP-001, ABP-671, SHR4640 and the like. The pharmaceutical composition provided by the invention can effectively reduce the concentration of uric acid in serum of a patient with hyperuricemia, so that the hyperuricemia is effectively prevented, treated or relieved. Compared with a single drug and the sum thereof, the combined drug composition can effectively inhibit serum uric acid, serum creatinine and urea nitrogen.

The application belongs to the technical field of urea nitrogen detection, and particularly relates to an integrated microfluidic chip device and method for detecting urea nitrogen; wherein a cover plate is bonded to a main plate, and the main plate is bonded to a base plate; the main plate is provided with a light path channel, a micro flow channel, a reaction chamber, a sample chamber, a control chamber and a groove; a photoelectric detector is fixed in the groove, an LED light source, a lens, a spectroscope and a reflecting mirror are fixed in the light path channel, the sample chamber and the reaction chamber are communicated through the micro flow channel, and the sample chamber and the outside are communicated through the micro flow channel; the cover plate is etched with an injection port communicated with the reaction chamber and the control chamber; the application adopts the microfluidic analysis chip idea, and through microfabrication technology, functional elements such as the LED light source, the lens, the spectroscope, the reflecting mirror, the reaction chamber, the sample chamber, the control chamber, the micro flow channel, the photoelectric detector and the main control chip are integrated on the chip like integrated circuits, and the idea of transferring the functions of the whole laboratory to the chip is concentratedly embodied.

The present invention discloses a composition for synergistically relieving physical fatigue and its application. The composition of the present invention can synergistically regulate anti-oxidation, calcium ion metabolism and energy metabolism, synergistically improve the body's ATP content and glycogen level, accelerate the clearance of lactic acid and urea nitrogen, prolong exercise time, and significantly relieve physical fatigue. Its synergistic effect is stronger than that of using red ginseng, black wolfberry and ganoderma lucidum alone. At the same time, the ingredients of the composition of the present invention are simple and all derived from natural plants; at the same time, after scientific demonstration and experimental verification, the mechanism of action of the composition is clear, and the fatigue-relieving interaction relationship between the various ingredients is clear, with the advantages of being green and safe. In addition, the preparation process of the composition of the present invention is simple and easy to operate, and does not require the investment of professional and technical personnel and large-scale instruments and equipment. The production cost is low, which is convenient for industrial development.

The utility model belongs to the technical field of distillation devices, and particularly relates to a urea nitrogen determination distillation device which comprises a base, the base comprises a supporting rod, a sliding groove, a spring and a lead screw, and a distillation assembly, a collecting assembly and a fixing assembly are arranged on the base. The fixing assembly comprises a sliding rod, a positioning hole, a through groove, a lifting rod, a limiting button, a supporting plate, a driving wheel, a driven wheel and a clamping plate. According to the utility model, the fixing devices are arranged on the distillation component and the collection component, the distillation flask is fixed above the heater by the supporting seat on the distillation component, and the smaller part above the distillation flask is clamped and fixed by the clamping device consisting of the spring and the clamping plate, so that the distillation flask cannot shake and incline when being heated; and on the collecting assembly, two lifting rods and a clamping plate can be close to the condensation pipe at the same time through cooperation of a spring, a lead screw, a sliding groove and a sliding rod, the fixed supporting capacity is provided for the condensation pipe, the situation that the condensation pipe inclines due to insufficient supporting force is avoided, and the device cannot incline or turn over during operation.