31results about How to "Inhibits oxidase activity" patented technology

The invention discloses a lactobacillus plantarum UA-416 strain and application thereof, and belongs to the field of functional food microbes. Blanks of lactobacillus plantarum in the effects of lowering uric acid and resisting gout are filled up. According to the lactobacillus plantarum (Lactobacillus plantarum) UA-416 strain provided by the invention, the bacterial strain is already collected inthe China Center for Type Culture Collection (CCTCC) on July 25, 2017; the collection number is CCTCC NO: M2017419. The lactobacillus plantarum UA-416 strain provided by the invention can be used foreffectively lowering the level of blood uric acid, is used for improving the levels of urea nitrogen and creatinine and inhibiting the activity of xanthine oxidase in serum, and has prevention and treatment effects on uricemia or the gout.

The invention discloses an L.plantarum UA149 strain and an application thereof, and belongs to the field of functional food microorganisms. The L.plantarum UA149 strain is deposited in China Typical Culture Collection Center on November 29, 2018 with the preservation number of CCTCC No: M2018842. The strain can be apply to preparing products with a uric acid reducing function or a gout resisting function. Lactic acid bacteria separated and identified from the surface of fleshy plant leaves are taken as research objects, and a new strain of lactic acid bacteria is screened through a large number of experiments. Hyperuricemia model rats are established by potassium oxazinate combined with fructose water, continuous intragastric administration of the lactobacillus plantarum UA149 strain for 14 days can significantly reduce the level of uric acid; and during gout attack, the release of inflammatory factors thromboxane and leukotriene mediated by neutrophils is reduced, the influx of neutrophils into joints is avoided, and the symptoms of redness, swelling, pain, heat and the like are reduced.

The invention relates to a drug for treating purine metabolic disorder disease, provides a flavonoids compound represented by the formula (I) and a modified derivative thereof, and a use in inhibition of xanthine oxidase activity and promotion of uric acid excretion function, wherein R1, R2 and R3 independently represent -H or monosaccharide residues, and R4 represents -H or -OH. In particular, the drug is used for treating purine metabolic disorder disease, and can be used for treating hyperuricemia and related diseases and reducing a individual serum UA level; the drug is used for treating hyperuricemia; the drug is used for treating the related diseases, such as for treating gouty arthritis and arthrophlogosis caused by hyperuricemia, and for treating chronic interstitial nephritis, kidney stones and the like caused by hyperuricemia. The drug has the advantages of natural chemical structure, safety, low toxicity, rapid curative effect and fewer side effects. (I).

The invention discloses a method for brewing cherry fruit wine. The method is characterized by comprising the following steps of: after selecting, washing and stoning cherries serving as raw materials, obtaining primary pulp by juicing; adding the following substances such as pectinase, calcium citrate, vitamin C, and g/L kojic acid into the primary pulp; standing for 5 to 24 hours; preparing clear juice by performing centrifugal separation; inoculating 0.05 to 2 percent of fruit wine yeast based on the weight of the clear juice; controlling a temperature and fermenting, wherein the primary fermentation temperature is between 16 and 28 DEG C, the fermentation time is 7 to 15 days, the secondary fermentation temperature is between 15 and 20 DEG C, and the fermentation time is 20 to 40 days; aging for 3 to 6 months; clarifying and filtering by adopting an ultra-filtration method; and filling, sterilizing and packaging to obtain finished cherry fruit wine. The method effectively improves a production process of cherry wine, reduces the content of polyphenol fundamentally, inhibits the activity of polyphenol oxidase, reduces harsh taste and improves stability. Compared with the prior art, the cherry fruit wine produced by the method maintains effective nutrient components, reduces the harsh taste and has a pure flavor.

The invention discloses a manufacturing technology of purple lycium barbarum leaf tea. The manufacturing technology comprises the steps of picking and cleaning purple lycium barbarum leaves, performing deactivation of enzymes for four times, rolling for molding and drying to realize formation. To be specific, the preliminary low-temperature deactivation of enzymes is executed, then middle-temperature water bath fumigation is executed, and finally, high-temperature frying is executed; the first three deactivation of enzymes is implemented from low temperature to high temperature, and the temperature is moderate and is always below 90 DEG C, so that the activity of oxidase of the purple lycium barbarum leaves is inhibited while other substances in the purple lycium barbarum leaves cannot be damaged; rapid cooling freezing is executed, so that the deactivation of enzymes is complete, furthermore, the nutritional components and trace elements in the lycium barbarum leaves can be retained in the leaves to the maximum extent, and in particular, the content of Zn in the purple lycium barbarum leaf tea is much higher than that of common green lycium barbarum leaf tea.

The invention belongs to the field of compound synthesis, and particularly relates to a geniposide derivative with xanthine oxidase inhibitory activity as well as a preparation method and application of the geniposide derivative. The geniposide derivative has a molecular structure shown in the specification. According to the invention, a novel geniposide derivative is synthesized, and the geniposide derivative has an obvious effect of inhibiting the activity of xanthine oxidase; the geniposide is subjected to structural modification, so that the biological activity of the geniposide can be greatly improved, and the geniposide has important practical significance on research and development of novel uric acid reducing drugs; according to the geniposide derivative with the xanthine oxidase inhibitory activity, related structural modification is carried out by taking geniposide as a raw material, the synthesis method is simple, the raw material price is low, and the structure is novel.

The invention discloses a processing method capable of prolonging a green tea shelf life, and belongs to the technical field of agricultural product storage and processing. The processing method comprises the following steps of 1, forecasting single layer moisture adsorption content of a processed green tea end product through a mathematical model according to a green tea isothermal adsorption curve, 2, carrying out microwave and far-infrared heating treatment on the processed green tea end product so that moisture activity of the processed green tea end product is controlled in a range of 0.2 to 0.4; and 3, packaging the processed green tea end product from the step 2 in a moisture-proof and light-proof environment, and storing the packaged green tea end product at normal temperature. The processing method adopts a microwave and far-infrared technology to carry out moisture activity control, thoroughly inhibits the activity of residual oxidase, minimizes chemical activities of green tea components, fundamentally inhibits various aging reactions in green tea storage, prevents oxidation of green tea active ingredients such as tea polyphenols, vitamin C and the like, maintains the most stable state of green tea, prevents green tea aging and deterioration in storage, and prolongs a green tea shelf life to the utmost extent.

The invention relates to the field of food, in particular to fructus gardeniae substitutional tea and a method for organoleptic optimization of a formula of the fructus gardeniae substitutional tea. The substitutional tea with specific proportioning components can effectively inhibit the activity of xanthine oxidase. The invention also provides a method for searching the organoleptic optimization of the formula of the fructus gardeniae substitutional tea. The optimal component ratio is finally obtained by establishing an optimization model and researching the influence of the components of the substitutional tea on the sense organs, and therefore, the sensory value of the substitutional tea is greatly improved while efficacy is ensured. According to the invention, development and utilization of cape jasmine resources are accelerated, a formula optimization thought is provided, economic development is driven, and ecological benefits and social benefits are improved.

The invention provides an allopurinol derivative shown in a formula I and a method for preparing the same. The allopurinol derivative can effectively inhibit tumor growth, and has a good antitumor effect; the allopurinol derivative can also effectively inhibit xanthine oxidase activity, can be used for gout treatment, and provides a new pharmaceutical option for clinically treating cancer and gout; and moreover, the preparation method of the compound is simple, is lower in cost, and has high yield and a good industrial application prospect.

The invention discloses a feed for artificial culturing of leiocassis longirostris. Raw materials of the feed comprise, in parts by weight, 18-26 parts of millet, 5-10 parts of cicada pupa powder, 2-8 parts of kelp powder, 1-5 parts of mulberry leaf powder, 30-40 parts of an adhesive, 1-5 parts of baikal skullcap roots, 1-2 parts of dandelion herbs, 1-2 parts of immature flower of Japanese honeysuckle, 0.5-1.2 parts of coptis roots, 0.15-0.35 part of EM bacteria, 0.2-0.6 part of lecithin, 0.1-0.3 part of beta-carotene, and 0.5-1 part of a phagostimulant. The feed for artificial culturing of the leiocassis longirostris provided by the invention can obviously raise the surviving rate of the leiocassis longirostris, improve economic benefits of the artificial culturing, and significantly decrease the generation of bacterium infection and diseases such as fatty liver in a culturing process. The feed improves the quality of the leiocassis longirostris, and contains no antibiotic.

The invention relates to glue and a preparation technology thereof, in particular to glue firm in adhesion and a preparation technology thereof. The glue is high in adhesion firmness, high in chemical corrosion resistance and water vapor erosion resistance, little in viscosity change after long-time storage and not prone to spoilage. The glue firm in adhesion is prepared from, by weight, 50-55 parts of ethyl cyanoacrylate monomers, 3-5 parts of acrylamide, 2-4 parts of emulsifier, 5-8 parts of ethyl cyanoacrylate and the like. The preparation technology includes five steps. The glue formed by mixing and reacting ethyl cyanoacrylate monomers, acrylamide, emulsifier, ethyl cyanoacrylate, an antioxidant, abietin and the like is little in viscosity change after long-time storage, free of offensive odor and toxin, harmless to bodies and capable of being used in life and industries, articles need to be attached to firm places, are not likely to fall off, can be maintained for a long time and is fixedly pasted.

The invention provides an allopurinol derivative shown in a formula I, as well as a preparation method and an application thereof. The allopurinol derivative can effectively inhibit tumor growth, and has a good antitumor effect; the allopurinol derivative can also effectively inhibit xanthine oxidase activity, can be used for gout treatment, and provides a new pharmaceutical option for clinicallytreating cancer and gout; and moreover, the preparation method of the compound is simple, is lower in cost, and has high yield and a good industrial application prospect.

The invention belongs to the technical field of medicines, and discloses application of herba lycopi flavone in preparation of anti-hyperuricemia and/or anti-gout medicines, hyperuricemia comprises primary and secondary hyperuricemia, and the concentration of uric acid in blood caused by various factors is higher than 420 [mu] mol/L for men and 357 [mu] mol/L for women (measured by a phosphotungstic acid reduction method). Or determining adult gout higher than 420 mu mol/L by a uricase-peroxidase coupling method, wherein the gout comprises primary gout and secondary gout. It is found that the herba lycopi flavone can significantly reduce the activity of xanthine oxidase in vitro and can effectively reduce the serum uric acid level of a hyperuricemia model mouse at the same time, and it is indicated that the herba lycopi flavone can be used for preparing the anti-hyperuricemia and/or anti-gout medicine. The invention provides a safe, effective and economical active substance for preparing medicines for preventing and/or treating hyperuricemia or/and gout diseases.

The invention belongs to the technical field of live vaccine protective agents, and particularly relates to a live vaccine, a live vaccine freeze-dried powder, a live vaccine protective agent as wellas a preparation method and application thereof. The live vaccine protective agent comprises water-soluble gelatin, oligosaccharides, sorbitol, polyvinylpyrrolidone, sodium ascorbate, sodium L-glutamate, a 199 culture medium and water for injection. The live vaccine protectant provided by the invention can increase the survival rate and shelf life of bacteria, and the protective function of the live vaccine protective agent on bacteria under a high temperature condition can be improved; and the situation of animal allergies and immune failure caused by improper storage of the live vaccine canbe also avoided.

The invention discloses a feed for improving leiocassis longirostris flavor, which is prepared from, by weight, 4-8 parts of guar gum sodium carboxymethylcellulose composite, 40-50 parts of high gluten flour, 16-20 parts of maltose, 4-8 parts of bacteriostat system, 1-3 parts of hawthorn, 2-4 parts of Amomum tsao-ko, 30-50 parts of germinated brown rice powder, 16-22 parts of earthworm powder, 10-16 parts of seaweed meal, 4-8 parts of pine needle meal, and 3-3.6 parts of intestinal tract promoter. The feed has advantages of improving immunity and survival rate of leiocassis longirostris, obviously improving the survival rate, increasing economic benefit of artificial cultivation, effectively inhibiting lipoxidase activity, reducing generation of aldehydes material, and greatly decreasing stink odor of leiocassis longirostris; meanwhile, the leiocassis longirostris excrement is few and water body is not polluted.