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Application of naja atra venin to treatment of diabetes and diabetic nephropathy complicating disease

A technology of cobra snake venom and diabetic nephropathy, which is applied in the field of cobra snake venom and preparation of drugs for the treatment of diabetes and diabetic nephropathy complications, can solve the problems that the effects of diabetes and diabetic nephropathy have not been reported, so as to improve renal function, reduce renal coefficient, less effect

Inactive Publication Date: 2012-07-04
SUZHOU RENBEN PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

With the deepening of research, now, snake venom and its products have been applied clinically. In addition to analgesic effect, research has found that it has good curative effect in anti-rheumatism, anti-tumor and treatment of nervous system diseases. However, in diabetes and The role of diabetic nephropathy has not been reported

Method used

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  • Application of naja atra venin to treatment of diabetes and diabetic nephropathy complicating disease
  • Application of naja atra venin to treatment of diabetes and diabetic nephropathy complicating disease
  • Application of naja atra venin to treatment of diabetes and diabetic nephropathy complicating disease

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Effect test

Embodiment

[0041] Embodiment: the animal pharmacodynamics experiment of the Chinese cobra venom after physical treatment

[0042] In the animal experiment of Chinese cobra venom in the treatment of diabetes and diabetic nephropathy, the embodiment adopts intragastric administration, and the dosage is 10-3000 μg / kg, once a day.

[0043] The cobra that adopts is the cobra that raises artificially, gathers venom under aseptic condition, becomes pale yellow powder through freeze-drying, and preserves at low temperature. The snake venom comes from Rainbow Snake Farm in Yujiang County, Jiangxi Province.

[0044] The animal experiment research situation of this embodiment is as follows:

[0045] Streptozotocin (STZ) is a widely used drug for rat diabetes models. Male Wistar rats with a body weight of 180-220 g were injected intraperitoneally with STZ (27.5 mg / ml) dissolved in pH=4.5 sodium citrate. ), calculated as 55mg / kg by body weight. The control group was injected with the same volume o...

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Abstract

The invention discloses an application of naja atra venin to preparation of a medicament for treating diabetes and a diabetic nephropathy complicating disease. As proved by animal experiments, after the total toxicity of naja atra venin which is modified and renatured physically in a range of 10-3,000 mug / kg is applied, the weight of a mouse suffering from diabetic nephropathy can be reduced, the blood sugar level of a mouse suffering from diabetes can be lowered, urokinase proteins are reduced, plasma albumin is raised, blood plasma triglyeride is reduced, plasma creatinine and urea nitrogen are reduced, the expression of inflammatory factors in kidney is reduced, the oxidative stress level is lowered, glomerulosclerosis is reduced, and nephridial tissue and islet injury are relieved.

Description

technical field [0001] The invention relates to the technical field of new application of medicine, and specifically relates to the application of physically modified cobra snake venom in the preparation of medicine for treating diabetes and diabetic nephropathy complications. Background technique [0002] Snake venom is a complex mixture of components secreted by the snake's venom glands. Fresh venom is egg white-like viscous liquid with a special fishy smell. The traditional medicine of the motherland believes that cobra and its toxic components can clear the meridians, dispel rheumatism, and have the effect of strengthening the body. As early as the beginning of the twentieth century, people began to use snake venom to relieve the pain of malignant tumors, neuralgia and joint pain, and then there were a series of reports about snake venom having morphine-like analgesic effects. With the continuous deepening of research, now, snake venom and its products have been applie...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/00A61K35/58A61P3/10A61P13/12A61K35/583
Inventor 秦正红朱扣柱谢燕
Owner SUZHOU RENBEN PHARMA
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