39 results about "Plasma Albumin" patented technology

A forage for piglet is prepared through dissolving 8 soluble materials (plasma albumin powder, whey powder, emulsified fat, glucose, etc) in water, mixing 5 insoluble materials (puffed soybean powder, fish powder, calcium hydrogen phosphate, etc), mixing both together, stirring, granulating, baking and cooling.

This invention describes a rapid immunochromatographic assay for measuring the ratio of glycated albumin to total albumin in saliva. Patients with diabetes have elevated levels of glucose in their blood that can react with plasma albumin to form glycated albumin. The amount of glycated albumin formed is directly correlated with the level of plasma glucose that the albumin has been exposed to over a period of time. Saliva albumin is derived from plasma albumin and therefore contains glycated and non-glycated albumin fractions that can be measured. The ratio of glycated albumin to total albumin in saliva will provide an indication of the average amount of protein glycation that occurred over the preceding 2-3 week period. The test is performed using a disposable strip that contains the testing reagents and the results are measured in a measuring instrument that automatically reads, calculates and displays the final result. The results of tests performed over a period of time are stored in the instrument's memory and presented in a numerical or graphical format so that the individual's glycated albumin level can be monitored over time.

This invention describes a rapid assay for measuring the ratio of glycated albumin to total albumin in blood. Patients with diabetes have elevated levels of glucose in their blood that can react with plasma albumin to form glycated albumin. The amount of glycated albumin formed is directly correlated with the level of plasma glucose that the albumin has been exposed to over a period of time. The ratio of glycated albumin to total albumin in blood will provide an indication of the average amount of protein glycation that occurred over the preceding 2-3 week period. The test is performed using a disposable strip or cassette that contains the testing reagents and the results are measured in a measuring instrument that automatically reads; calculates and displays the final result: The results of tests performed over a period of time are stored in the instrument's memory presented in a numerical or graphical format so that the individual's glycated albumin level can be monitored over time.

This invention describes a point-of-care or home use device for measuring the ratio of glycated albumin to total albumin in saliva and other body fluids. Diabetics and prediabetics may have elevated levels of glucose in their blood that can react with plasma albumin to form glycated albumin. The amount of glycated albumin formed is directly correlated with the level of plasma glucose that the albumin has been exposed to over a period of time. Saliva albumin is derived from plasma albumin and therefore contains glycated and non-glycated albumin fractions that can be measured. The ratio of glycated albumin to total albumin in saliva will provide an indication of the average amount of protein glycation that occurred over the preceding 2-3 week period.The test is performed using a disposable strip or cassette that contains the testing reagents and the results are measured in a measuring instrument that automatically reads, calculates and displays the final result. The results of tests performed over a period of time are stored in the instrument's memory and presented in a numerical or graphical format so that the individual's glycated albumin level can be monitored over time.

This invention describes a rapid immunochromatographic assay for measuring the ratio of glycated albumin to total albumin in saliva. Patients with diabetes have elevated levels of glucose in their blood that can react with plasma albumin to form glycated albumin. The amount of glycated albumin formed is directly correlated with the level of plasma glucose that the albumin has been exposed to over a period of time. Saliva albumin is derived from plasma albumin and therefore contains glycated and non-glycated albumin fractions that can be measured. The ratio of glycated albumin to total albumin in saliva will provide an indication of the average amount of protein glycation that occurred over the preceding 2-3 week period.The test is performed using a disposable strip that contains the testing reagents and the results are measured in a measuring instrument that automatically reads, calculates and displays the final result. The results of tests performed over a period of time are stored in the instrument's memory and presented in a numerical or graphical format so that the individual's glycated albumin level can be monitored over time.

The invention belongs to the technical field of medicines, and relates to a redox sensitive albumin binding prodrug with a series of tumor tissue specific responses. The albumin binding prodrug is ananti-tumor drug-maleimide molecule prodrug particularly including three docetaxel-maleimide small molecule prodrugs; by utilizing a maleimide ring in a prodrug structure as a target head of plasma albumin 34-bit free sulfydryl in a binding body, so that after a drug enters into a body through intravenous injection, the drug is quickly and specifically bound with albumin to form an albumin-drug composition; therefore, the drug stability is enhanced, the circulation time of the drug in the boy is obviously prolonged, and accumulation of the drug on tumor tissues is realized by utilizing an EPR (Enhanced Permeability and Retention) effect. In addition, in the prodrug structure, by using a redox sensitive key as a binding key, quick release of the drug in tumor cells is promoted, a toxic effect of the drug on normal cells also can be alleviated, the prodrug has high selectivity, the aims of increasing an effect and reducing the toxicity of docetaxel are fulfilled, and a greater market application prospect is achieved.

This invention describes a rapid assay for measuring the ratio of glycated albumin to total albumin in blood. Patients with diabetes have elevated levels of glucose in their blood that can react with plasma albumin to form glycated albumin. The amount of glycated albumin formed is directly correlated with the level of plasma glucose that the albumin has been exposed to over a period of time. The ratio of glycated albumin to total albumin in blood will provide an indication of the average amount of protein glycation that occurred over the preceding 2-3 week period.The test is performed using a disposable strip or cassette that contains the testing reagents and the results are measured in a measuring instrument that automatically reads, calculates and displays the final result. The results of tests performed over a period of time are stored in the instrument's memory and presented in a numerical or graphical format so that the individual's glycated albumin level can be monitored over time.

The invention relates to a human high density lipoprotein and product, preparation process and use thereof, which comprises producing human plasma albumin and gamma globulin by employing low-temperature ethanol method, using discarded FIV-1 deposition as raw material, extracting HDL from FIV-1 through separation and purification steps. The prepared human high density lipoprotein and product can be applied for the preparation of medicament for treating multiple organ disturbance syndrome (MODS) and cardiovascular diseases such as atherosclerosis (AS).

An intestinal nutrition peptide as an additive of feed for piglet is prepared from one or more of oligopeptide, plycyl-L-glutamine, alanyl glutamine and iron glycinate. It can prevent the delactation stress of piglet and can be used to replace to plasma albumin powder. Said oligopeptide is prepared from soybean protein and rapeseed protein through sterilizing, enzymolyzing, deactivating enzyme and ultra-filtration.

The invention discloses an application of naja atra venin to preparation of a medicament for treating diabetes and a diabetic nephropathy complicating disease. As proved by animal experiments, after the total toxicity of naja atra venin which is modified and renatured physically in a range of 10-3,000 mug / kg is applied, the weight of a mouse suffering from diabetic nephropathy can be reduced, the blood sugar level of a mouse suffering from diabetes can be lowered, urokinase proteins are reduced, plasma albumin is raised, blood plasma triglyeride is reduced, plasma creatinine and urea nitrogen are reduced, the expression of inflammatory factors in kidney is reduced, the oxidative stress level is lowered, glomerulosclerosis is reduced, and nephridial tissue and islet injury are relieved.

A tip filter containing nano-material for cigarette is prepared through adding sodium selenite to the solution containing plasma albumin and heme, constant temp, adding hydrazine hydrate, reacting to become nano-material, preparing the solution of glyceride acetate, spraying it onto acetate fibers, and rolling.

The invention provides medicine for treating uremia and urine protein. The medicine is a mixture of glycoprotein or polysaccharide and protein or polypeptide or protein. The medicine achieves a good treatment effect for uremia and urine protein, and after three treatment courses are completed, the total effective rate is 84-94%; the medicine lowers toxin of uremia and urine protein and remarkably lowers the content of SCr, the content of urine protein and the content of blood urea nitrogen, after three treatment courses are completed, the SCr content of a patient is 282.4-290. micromole / L, the urine protein content is 2.42-2.54 g / 24h, and the blood urea nitrogen content is 14.2-15.0 mmol / L. The medicine improves the nutrition condition of the organism, raises the content of plasma albumin (Alb) and the content of hemoglobin (Hb), improves the immunity, has the advantages of being safe, high in efficiency and free of side effect and has an obvious treatment effect for uremia and urine protein.

The invention relates to a drug for treating chronic kidney disease proteinuria, which is a capsules prepared as follows: the materials are astragalus, Oriental Waterplantain Rhizome, Chinese Magnolivine Fruit, fried foxnut and node of lotus rhizome, which are added to water to be decocted, and the decoction solution is concentrated and dried. The drug has the advantages of kidney invigorating, diuresis inducing and stranguria treating, blood activating and stasis removing, swelling reducing and pain alleviating, heat-clearing and detoxifying, body fluid regenerating and thirst quenching, darrhea relieving, cough relieving and bleeding stopping, which has the function of body immunity regulation and reinforcing, and is suitable for the patient with chronic kidney disease and chronic renal failure proteinuria; the drug can effectively reduce proteinuria, increase plasma albumin, reduce the pathological changes of kidney and improve hemorheology indexes, which has a certain controlling effect on hematuria and proteinuria. In clinical verification, the drug has the advantages of fast therapeutic effect, good efficacy and small side effect.

The invention belongs to the technical field of medicine and relates to an albumin-bound near-infrared fluorescent dye-maleimide conjugate. The albumin-bound near-infrared fluorescent dye-maleimide conjugate specifically replaces chlorine in the conjugated chain of the cyanine dye with a group containing maleimide, and the optical properties are modified by intramolecular charge transfer effects to enable the conjugate to be used as a blue bio-dye. Secondly, the maleimide group in the conjugate can be covalently bound to a free sulfhydryl group at position 34 of cysteine on plasma albumin by aMichael addition reaction, so that the conjugate has excellent lymph node targeting. A near-infrared fluorescent biological imaging agent overcomes the defects of an imaging method used in clinical sentinel lymph node navigation surgery, and is safe, reliable, accurate in positioning, and high in imaging efficiency. The two imaging modes, blue-stained macroscopic recognition and near-infrared fluorescence imaging, are integrated to enable dual imaging function of lymph nodes in vivo.

The invention discloses a traditional Chinese medicine compound preparation used for treating nephrotic syndrome hypoproteinemia. Nephritic syndrome hypoproteinemia has clinical indications of plasma-albumin lower than 30g / L, lower extremities edema and hydrothorax and ascites with different degrees, poor appetite, hypodynamia, abdominal distention; or companied skin eczema, and bitter taste and dryness of mouths; or companied purplish mouth, lips or tongues, and purplish and expended sublingual venae. The compound preparation provides functions of spleen strengthening, kidney benefiting, blood circulation promoting, meridian obstruction removing, heat clearing, and dampness eliminating. The compound preparation is an oral preparation composed of an active component extract and medicinal auxiliary materials. The active component extract is at least extracted from black soybean, Mongolian milkvetch root, common yam rhizome, swordlike atractylodes rhizome, ligusticum, and leeches. The invention also discloses an extraction method of the active components and an application thereof in preparing medicines used for preventing and treating nephrotic syndrome hypoproteinemia.

The invention provides a medicated food for improving the nutrition state of liver cirrhosis, which is prepared from the following raw materials: tuckahoe, coix seed, Chinese yam, finger citron, endothelium corneum gigeriae galli, jujubes and ordinary rice; and the raw materials have the effects of strengthening the spleen and eliminating dampness as well as soothing the liver and regulating the flow of qi. By virtue of the characteristics of foods according to the homology of medicines and foods, the medicated food can supply partial energy and nutritional ingredients required by patient bodies; and moreover, by virtue of the effects of the traditional Chinese medicine components for strengthening the spleen and eliminating dampness as well as promoting qi circulation for diuresis, the functions of tri-jiao for promoting qi circulation, dredging collaterals and promoting diuresis are optimal, so that pathological factors are eliminated, the physiological functions of the liver are improved, physiologic conditions favorable for repairing liver tissues are formed, and a benign auxiliary treatment effect on the condition of a patient suffering liver cirrhosis is achieved. The medicated food has the effects of increasing plasma albumin, promoting liver regeneration and promoting recovery of liver functions. The invention provides a new simple, feasible, economical, practical, safe and effective method for auxiliary treatment of the patient suffering liver cirrhosis in the decompensated period. Through clinical practice for many years, the effective rate of the medicated food is 92.7%.

The invention discloses an application of notoginsenoside R1 in preparation of drugs for treating small intestinal mucosal injury, intestinal inflammatory cell infiltration and increase in microvessel permeability caused by ischemia / reperfusion. The application is realized by a way that the notoginsenoside R1 inhibits I[kappa]B[alpha] degradation and metastasis of NF-[kappa]BP65 translocates to cell nuclei, and then inhibits inflammatory cytokine release; the application is realized by a way that the notoginsenoside R1 inhibits leukocytes to swim out of microvessels, so as to avoid infiltration in tissues; the application is realized by a way that the notoginsenoside R1 inhibits cell apoptosis; the application is realized by a way that the notoginsenoside R1 inhibits degradation of vascular intercellular tight-junction proteins and inhibits plasma albumin leakage; and the application is realized by a way that the notoginsenoside R1 regulates ATP5D, increases the content of ATP in intestinal canal tissues, and promotes repair of intestinal mucosa epithelial cells.

A forage for piglet is prepared through dissolving 8 soluble materials (plasma albumin powder, whey powder, emulsified fat, glucose, etc) in water, mixing 5 insoluble materials (puffed soybean powder, fish powder, calcium hydrogen phosphate, etc), mixing both together, stirring, granulating, baking and cooling.

The invention provides a Chinese medicinal preparation for treating hypoproteinemia caused by liver damage, which is prepared from panax ginseng, siberian solomonseal rhizome, rehmanniae praeparatum, Chinese angelica, figwort root, tortoise-shell glue, szechuan lovage rhizome, large-headed atractylodes rhizome, Chinese thorowax root and the like. The Chinese medicinal preparation has the effects of soothing the liver and tonifying the spleen, invigorating blood circulation and removing blood stasis, softening hard lumps and dispelling nodes and nourishing vital qi, can eliminate ascites and improve plasma albumin obviously on patients who suffer from cirrhosis ascites with low albumin so as to regulate the viscera function of bodies integrally without attending to one thing and losing another, and has the advantages of long-term administration and no toxic or side effect.

The invention provides an albumin peptide beverage, a preparation method and an application in improvement of plasma albumin indexes. The albumin peptide beverage comprises the following raw materials by weight: egg white, green papaya, pineapple, momordica grosvenori, cranberry, vitamin B6, vitamin B12, nicotinic acid, sucralose, citric acid, maltodextrin, fructo-oligosaccharide and water. Fresh fruits such as green papaya, pineapple, siraitia grosvenorii and cranberry are directly adopted to hydrolyze egg white to prepare the albumin peptide beverage, the beverage is not concentrated into powder and then compounded, other chemical proteases and preservatives are not added, short peptides with activity can be generated through hydrolysis, and the beverage is closer to human body nutritional requirements and nutritional ingredient proportion requirements, is beneficial to promoting digestion and absorption of the body, reduces allergic reaction of the human body to the egg white, can increase the content of plasma albumin and total protein, is used for daily and clinical protein nutritional supplements, and is simple in production process, low in equipment difficulty and good in product taste, and rapid, complete and efficient industrial production can be realized.

The invention relates to a method for qualitative and quantitative analysis of non-enzymatic glycosylated plasma albumin. After reductive alkylation of plasma albumin and trypsin enzymolysis, non-enzymatic glycosylation of the plasma albumin is analyzed qualitatively and quantitatively by nanoliter liquid chromatography-multistage mass spectrometry (nL-MSn) and isobaric tags for relative and absolute quantitation (iTRAQ). The plasma albumin is degraded into peptide fragments by reductive alkylation and trypsin enzymolysis, amino acid sequence and glycosylation site information are obtained byhigh-resolution mass spectrometry after nanoliter liquid phase separation, and accurate quantification of the glycosylation site is achieved by iTRAQ reporter ions. The invention realizes the comprehensive qualitative and quantitative analysis of the glycosylation site of plasma albumin and can be used for the monitoring of blood glucose concentration and the detection of early diabetes.

The invention discloses an ointment for protecting kidney and invigorating kidney, consisting of the following raw materials in parts by weight: 100-300 part of honey, 100-200 parts of astragalus root, 50-100 part of atractylodes macrocephala, 80-150 parts of motherwort, 50-100 parts of salvia miltiorrhiza, 60-120 parts of peach kernel, 50-150 part of hedyotis diffusa, 20-60 parts of morning glory, 30-80 parts of periostracum cicadae, 50-100 parts of tuckahoe, 30-80 parts of polyporus umbellatus and 20-60 parts of rhubarb. The ointment has the effects of invigorating kidney and lung, clearingblood, invigorating spleen, diuresis and detumescence, reducing proteinuria and edema, improving plasma albumin, and protecting kidney function.

The present application relates to a series of redox-sensitive albumin-bound prodrugs specifically responsive to tumor tissue, and in particular, to three small-molecule docetaxel-maleimide prodrugs. A maleimide ring in the prodrug structure is used as a target for binding a free thiol group at position 34 of a plasma albumin in the body, such that the drug rapidly and specifically binds to the albumin after intravenous injection into the body and forms an albumin-drug complex, thereby enhancing drug stability and significantly prolonging the circulation time of the drug in the body. Furthermore, the EPR effect is leveraged to achieve drug accumulation in tumor tissue.

The medicine for increasing leukocyte comprises 10 Chinese medicinal materials of turtle shell, millettia root and stem, ginseng, prepared flowery knotweed root, jujube and others. Its preparation process includes the following steps: (1). drying and pulverizing turtle shell to obtain fine powder; (2) making millettia root and stem into millettia paste; and (3) making other ingredients into oral liquor, said three portions are formed into the medicine with the functions of raising physiological function and immunity of human body and a certain anticancer action. It has no any adverse reactions.

The invention provides a medicated food for improving the nutrition state of liver cirrhosis, which is prepared from the following raw materials: tuckahoe, coix seed, Chinese yam, finger citron, endothelium corneum gigeriae galli, jujubes and ordinary rice; and the raw materials have the effects of strengthening the spleen and eliminating dampness as well as soothing the liver and regulating the flow of qi. By virtue of the characteristics of foods according to the homology of medicines and foods, the medicated food can supply partial energy and nutritional ingredients required by patient bodies; and moreover, by virtue of the effects of the traditional Chinese medicine components for strengthening the spleen and eliminating dampness as well as promoting qi circulation for diuresis, the functions of tri-jiao for promoting qi circulation, dredging collaterals and promoting diuresis are optimal, so that pathological factors are eliminated, the physiological functions of the liver are improved, physiologic conditions favorable for repairing liver tissues are formed, and a benign auxiliary treatment effect on the condition of a patient suffering liver cirrhosis is achieved. The medicated food has the effects of increasing plasma albumin, promoting liver regeneration and promoting recovery of liver functions. The invention provides a new simple, feasible, economical, practical, safe and effective method for auxiliary treatment of the patient suffering liver cirrhosis in the decompensated period. Through clinical practice for many years, the effective rate of the medicated food is 92.7%.

The goal of the present invention is to provide substances to prevent diseases by activating inherently possessed functions, for cultured fishes and shellfishes and livestock with tendency of decreased immune function due to densely populated breeding environment, and for humans with tendency of easily lowered immune functions due to complicated social structures and aging. The present invention expresses marked effect in preventing infection and cancer by administrating appropriate dose of swine plasma, swine plasma albumin, peptides isolated from swine plasma and swine plasma albumin, and swine plasma mixture, among others including fine powder of Crustacea (including crust of Crustacea), to activate immune function of Crustacea, Pisces, Aves, Mammals, and humans.

The invention discloses an albumin binding type camptothecin derivative prodrug, a preparation method of the albumin binding type camptothecin derivative prodrug and application of the albumin binding type camptothecin derivative prodrug in an anti-tumor drug delivery system. According to the prodrug, a series of prodrugs are prepared by connecting a camptothecin derivative and a maleimide group which can be rapidly and specifically combined with albumin through a beta-glucuronidase cleavable connecting chain. After intravenous injection of the prodrug, the maleimide group of the prodrug and sulfydryl of 34-site cysteine of plasma albumin are subjected to Michael addition to form a macromolecular albumin drug-loading system, passive accumulation of tumors is realized under the EPR effect and albumin receptor mediation, camptothecin derivatives are released through a tumor microenvironment, the anti-tumor effect is improved, and the prodrug has a good application prospect. The compound can be applied to preparation of anti-tumor drugs.