98 results about "Alanyl glutamine" patented technology

The invention relates to the technical field of the preparation for alanyl-glutamine dipeptide and particularly discloses a method for preparing alanyl-glutamine dipeptide through biological enzyme conversion. The method comprises the following steps: 1) preparing a biological enzyme liquid: dissolving the biological enzyme in a buffered liquid, controlling pH value within the scope of 7.0+ / -2.0, controlling the temperature at 5-10 DEG C, thereby acquiring the biological enzyme liquid, wherein the mass fraction of the ester acyl-containing transferring biological enzyme is 5%-20%; 2) dissolving the ester derivates of substrate L-alanine and glutamine in pure water, and then uniformly dropping the biological enzyme liquid into a reaction liquor, and meanwhile, adding acid liquor or alkali liquor, controlling the pH of the reaction liquor at 5-10, reacting under the temperature controlled at 15-25 DEG C, sampling and detecting the production of the alanyl-glutamine dipeptide during the reaction process, stopping reaction when the content of the alanyl-glutamine dipeptide is highest, and separating the acquired converted liquid, thereby acquiring the alanyl-glutamine dipeptide. According to the method provided by the invention, the enzyme activity is high, the reaction rate of the materials is higher, the method has the advantages of simple technique control, easy control on quality index and low cost, and the method is more fit for industrial production.

The invention relates to a pharmaceutical composition of an alanyl glutamine injection and a compound amino acid injection, in particular to combination application package. The pharmaceutical composition comprises the alanyl glutamine injection and the compound amino acid injection. When the pharmaceutical composition is in use, the alanyl glutamine injection and the compound amino acid injection are jointly utilized and are intravenously dripped. The combination application package greatly facilitates the requirement of clinical application.

An intestinal nutrition peptide as an additive of feed for piglet is prepared from one or more of oligopeptide, plycyl-L-glutamine, alanyl glutamine and iron glycinate. It can prevent the delactation stress of piglet and can be used to replace to plasma albumin powder. Said oligopeptide is prepared from soybean protein and rapeseed protein through sterilizing, enzymolyzing, deactivating enzyme and ultra-filtration.

The invention relates to a refining method of an alanyl-glutamine crude drug. The method comprises the following processes: adding an alanyl-glutamine crude product to water, stirring until the alanyl-glutamine crude product is completely dissolved; adding alkali to adjust the pH value, adding active carbon, stirring for realizing absorption; filtering and decolorizing to obtain clear material liquid, then adding a polar solvent, crystallizing and filtering; and drying to obtain an alanyl-glutamine refined product. By adopting the refining method, alanyl-glutamine impurities and the content of bacterial endotoxin are effectively controlled; the target of intravenous administration is achieved; and the safety of alanyl-glutamine intravenous preparations is also improved.

The invention provides a N(2)-L-alanyl-glutamine for injection and its preparing method, it has mixed N(2)-L-alanyl-glutamine and mannite to make N(2)-L-alanyl-glutamine whose mess percentage density is 50-100%. The invention has increased the stability of medicine greatly, convenient for transportation and storage, suitable for sicker in catabolism and hypermetabolism condition who needs glutamine.

The invention provides a dandruff-removing itch-relieving composition and a preparation method and application method thereof. The dandruff-removing itch-relieving composition is prepared from the following raw materials in parts by weight: 4-10 parts of dihydrogen oat alkaloid, 4-8 parts of alanyl glutamine, 5-30 parts of a thickener, 10-25 parts of organic alcohol, 5-10 parts of a surfactant, and 20-60 parts of a dispersing agent. The used raw materials are clear in component, and have little irritation to scalp cells; the dandruff-removing itch-relieving composition containing the dihydrogen oat alkaloid and the alanyl glutamine has a relatively good sterilization effect and anti-allergy effect, nourishes the scalp, slows down the abnormal rapid defluvium of stratum corneum cells of thescalp, and has an obvious itch-relieving effect; in addition, the composition is transparent liquid in appearance, and can be directly added into existing shampoo under room temperature to prepare dandruff-removing itch-relieving shampoo; development of new products, especially transparent shampoo products, by manufactures is convenient; the problems that existing dandruff-removing itch-relievingfunctional components cannot be directly added and / or preparation of the transparent shampoo is difficult are effectively solved.