Preparation method of L-alanyl-L-glutamine

A technology of glutamine and alanyl, applied in the field of medicine, can solve the problems that hydrazine residues are difficult to completely remove, unfavorable for operation safety, and unfavorable for environmental protection, so as to reduce the steps of water extraction products, reduce production costs and The effect of three wastes and simplified post-treatment methods
CN102838656AActive Publication Date: 2012-12-26山东诚汇双达药业有限公司
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
山东诚汇双达药业有限公司
Publication Date
2012-12-26

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Abstract

The invention relates to a preparation method of L-alanyl-L-glutamine; the preparation method comprises the following steps of: a) adding a solvent to a reaction container; stirring the solvent; and then adding N-phthaloyl-L-alanyl-L-glutamine to the reaction container; putting the reaction container in an ice bath; dripping a short-chain amine solution into a solution for clarification; removing the ice bath; adding the rest short-chain amine solution to the solution; after finishing dripping, carrying out room temperature reaction on the solution; decompressing and concentrating the solution to remove excessive short-chain amine in a water bath until the pH value of the solution is 6-7; standing for crystallization; filtering crystals; and drying filter cakes at a normal pressure so as to obtain a crude product; and b) adding water to the crude product at room temperature; dissolving the crude product in the water; dripping short-chain alcohol into the water for crystallization and purification during stirring, so as to obtain the L-alanyl-L-glutamine. Through the adoption of the preparation method of the L-alanyl-L-glutamine provided by the invention, hypertoxic hydrazine hydrate is avoided; and the preparation method of the L-alanyl-L-glutamine provided by the invention has the advantages of greater safety in operation, high product purity, high optical rotation and low impurity content.
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Description

technical field

[0001] The invention belongs to the technical field of medicine and relates to a preparation method of L-alanyl-L-glutamine. Background technique

[0002] L-alanyl-L-glutamine, abbreviated as dipeptide, was developed by Fresenius AG of Germany. It was launched in Germany in 1995 and in China in 1999. The trade name is 20% dipep-tamin. Lipeptide has the functions of promoting positive nitrogen balance and regulating muscle protein synthesis. As an important component of parenteral nutrition, it can prevent the increase and atrophy of small intestinal mucosal permeability caused by long-term application of parenteral nutrition, and can enhance immune function and Prevention of bacteremia in patients requiring glutamine supplementation, including those in catabolic and hypermetabolic conditions. The structural formula of L-alanyl-L-glutamine is as follows:

[0003]

[0004] Patent CN1651456 discloses a method for preparing L-alanyl-L-glutamine with phthaloy...

Claims

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