N(2)-L-alanyl-L-glutamine/compound amino acid injection (18AA-V) pharmaceutical composite preparation
A 18AA-V, compound amino acid technology, applied in the directions of drug combination, drug delivery, pharmaceutical formulation, etc., can solve the problems of not exceeding 3.5%, failing to meet clinical requirements, etc., achieving less adverse reactions, good application prospects, and scope of application wide effect
Active Publication Date: 2013-05-01
ZHEJIANG CHANGDIAN PHARMA
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Problems solved by technology
[0003] Since N(2)-L-alanyl-L-glutamine has the function of promoting positive nitrogen balance, and its solution is a hypertonic solution, the maximum concentration of the infusion solution should not exceed 3.5%. , there will be serious adverse reactions such as nitrogen loss, vascular stimulation and dehydration of vital organs, which will cause N(2)-L-alanyl-L-glutamine to fail to meet clinical requirements
Method used
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Experimental program
Comparison scheme
Effect test
Embodiment 1
[0012] N(2)-L-alanyl-L-glutamine / compound amino acid injection (18AA-V) drug combination preparation is made of the following components by weight:
[0013] N(2)-L-alanyl-L-glutamine for injection 10g;
[0014] Sterile water for injection 50ml;
[0015] Compound amino acid injection (18AA-V) 250ml: 8.06g (total amino acid) and 12.5g xylitol.
Embodiment 2
[0017] N(2)-L-alanyl-L-glutamine / compound amino acid injection (18AA-V) drug combination preparation is made of the following components by weight:
[0018] N(2)-L-alanyl-L-glutamine for injection 20g;
[0019] Sterile water for injection 100ml;
[0020] Compound amino acid injection (18AA-V) 500ml: 16.12g (total amino acid) and 25g xylitol.
[0021] Quality Research Survey
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The invention relates to the technical field of medicines and discloses an N(2)-L-alanyl-L-glutamine / compound amino acid injection (18AA-V) pharmaceutical composite preparation which is prepared by mixing N(2)-L-alanyl-L-glutamine and compound amino acid injection (18AA-V). The pharmaceutical composite preparation has the advantages of definite components, stable quality, high bioavailability, less adverse reactions and the like and has a good application prospect in clinical practice.
Description
technical field [0001] The invention relates to the technical field of medicine, in particular to an N(2)-L-alanyl-L-glutamine / compound amino acid injection (18AA-V) drug combination preparation. Background technique [0002] N(2)-L-alanyl-L-glutamine is a component of parenteral nutrition, which can promote positive nitrogen balance, regulate muscle protein synthesis, and prevent intestinal mucosal passage caused by long-term parenteral nutrition. Increased permeability and atrophy, C can enhance immune function and prevent the occurrence of bacteremia. N(2)-L-alanyl-L-glutamine can be decomposed into alanine and glutamine in the body, and glutamine can be supplemented by parenteral nutrition infusion. [0003] Since N(2)-L-alanyl-L-glutamine has the function of promoting positive nitrogen balance, and its solution is a hypertonic solution, the maximum concentration of the infusion solution should not exceed 3.5%. , there will be serious adverse reactions such as nitrogen...
Claims
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Patent Timeline
Login to View More IPC IPC(8): A61K38/05A61K9/08A61P3/02A61K31/4172A61K31/405A61K31/401A61K31/198
Inventor 傅苗青历达中陈宇东
Owner ZHEJIANG CHANGDIAN PHARMA