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Delivery of therapeutic biologicals from implantable tissue matrices

InactiveUS6692738B2Many of effectMany of inconvenienceBiocidePowder deliveryProgenitorActive agent
Normal cells, such as fibroblasts or other tissue or organ cell types, are genetically engineered to express biologically active, therapeutic agents, such as proteins that are normally produced in small amounts, for example, MIS, or other members of the TGF-beta family Herceptin(TM), interferons, andanti-angiogenic factors. These cells are seeded into a matrix for implantation into the patient to be treated. Cells may also be engineered to include a lethal gene, so that implanted cells can be destroyed once treatment is completed. Cells can be implanted in a variety of different matrices. In a preferred embodiment, these matrices are implantable and biodegradable over a period of time equal to or less than the expected period of treatment, when cells engraft to form a functional tissue producing the desired biologically active agent. Implantation may be ectopic or in some cases orthotopic. Representative cell types include tissue specific cells, progenitor cells, and stem cells. Matrices can be formed of synthetic or natural materials, by chemical coupling at the time of implantation, using standard techniques for formation of fibrous matrices from polymeric fibers, and using micromachining or microfabrication techniques. These devices and strategies are used as delivery systems via standard or minimally invasive implantation techniques for any number of parenterally deliverable recombinant proteins, particularly those that are difficult to produce in large amounts and / or active forms using conventional methods of purification, for the treatment of a variety of conditions that produce abnormal growth, including treatment of malignant and benign neoplasias, vascular malformations (hemangiomas), inflammatory conditions, keloid formation, abdominal or plural adhesions, endometriosis, congenital or endocrine abnormalities, and other conditions that can produce abnormal growth such as infection. Efficacy of treatment with the therapeutic biologicals is detected by determining specific criteria, for example, cessation of cell proliferation, regression of abnormal tissue, or cell death, or expression of genes or proteins reflecting the above.
Owner:THE GENERAL HOSPITAL CORP

Protective shield for aircraft cockpit crew

This invention relates generally to the field of aircraft technology and systems utilized for protection of aircraft, occupants, and operators thereof from hijackers, terrorists, and other anomalous problems while in flight. More particularly, the present invention relates to a device used in conjunction with walls, floor, and ceiling of a cockpit's entry/exit passageway for protecting the cockpit crew from weapons, hostility, decompression, and/or physical intrusions. A light weight protective shield for the cockpit of an aircraft (i.e. bullet-proof door) along with a internal locking and release device, none of which is provided by prior art. The protective shield can absorb repeated blows, provide pressure relief in the event of aircraft decompression, resist penetration of firearms, knives, and explosive devices, and is compliant with FAA regulations. The protective shield provides a new level of protection for the crew of a passenger or cargo airplane and protects the cockpit of an aircraft from hijacking attempts as well as other anomalous events and is comprised of a light weight weapon-proof protective shield that when closed fits snugly with the flight deck's adjoining floor, walls, and ceiling. This protective shield system is intended to readily install inside existing aircraft (e.g. over-night retrofit installation) or be installed into new aircraft as they are assembled.
Owner:PITTMAN DONALD MERVE
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