12 results about "Propanoyl chloride" patented technology

The invention relates to the field of pipes, and discloses a high-strength CPVC pipe and a preparation method thereof.The pipe comprises CPVC resin, modified multi-walled carbon nanotubes, modified nano silicon dioxide and auxiliaries; the modified multi-walled carbon nanotubes are prepared by grafting phosphorus-containing cardanol derivative based benzoxazine and oxidized multi-walled carbon nanotubes; phosphorus-containing cardanol derivative benzoxazine reacts with 1, 5-naphthylenediamine to prepare an aldehyde cardanol intermediate, the aldehyde cardanol intermediate is prepared by reacting paraformaldehyde with hydrogenated cardanol, the obtained cardanol derivative and DOPO are subjected to addition, and then the obtained phosphorus-containing cardanol derivative reacts with paraformaldehyde and 3-aminopropyltriethoxysilane to prepare the flame retardant. The modified nano silicon dioxide is prepared by introducing polyethylene glycol into the surface of isocyanated nano silicon dioxide and grafting with 3, 5-bis (tert-butyl)-4-hydroxybenzene propionyl chloride, and the pipe prepared by the invention is high in tensile strength and impact strength and has good long-acting oxidation resistance, high temperature resistance and flame retardance.

The application discloses a triazolinone compound, and a preparation method thereof. The structural general formula (I) of the triazolinone compound is as follows: the preparation method is to perform esterification or amidation reaction on a compound containing a hydroxyl group or an amino group as raw material in a solvent and 2-chloro-3-(2-chloro-5-(4-difluoromethyl-3-methyl-5-oxo-1,2,4-triazol-1-yl)-4-fluorophenyl) propionyl chloride prepared through acyl chloride reaction, so as to obtain a triazolinone structure-containing herbicidal compound. The preparation method is simple, the reaction process is short, and the triazolinone structure-containing herbicidal compound has the advantages of novel structure, high herbicidal activity and the like.

This invention belongs to the field of pharmaceutical synthesis, specifically relating to a method for preparing etorizine hydrochloride and its intermediates. Specifically, it involves reacting propionyl chloride and ethylbenzene at -80 to -50°C to obtain p-ethylphenylacetone, which is then reacted with piperidine and paraformaldehyde to form a salt, yielding etorizine hydrochloride. The method for preparing p-ethylphenylacetone provided by this invention can obtain a product with a low content of compound II. Using this as a raw material to prepare etorizine hydrochloride simplifies post-processing, improves yield, and ensures that the content of compound III meets pharmacopoeia standards, making it suitable for industrial production.

The invention discloses a preparation method of an indoxacarb high-purity intermediate, and belongs to the technical field of pesticide synthesis. Mixing chlorobenzene, 3-chloropropionyl chloride and the modified charcoal, stirring and reacting to obtain a first mixed solution; heating and stirring the first mixed solution for reaction to obtain a second mixed solution; adding dimethyl carbonate and anhydrous potassium carbonate into the second mixed solution, mixing and performing reflux reaction to obtain a third mixed solution; and sequentially carrying out reduced pressure distillation and ethanol recrystallization on the third mixed solution to obtain the high-purity indoxacarb intermediate. According to the invention, a molecular imprinting-coordination-sulfur doping synergistic catalysis system is constructed through three-step modification, so that precise recognition and efficient catalysis cooperation are realized, and the reaction selectivity and the product purity are improved. The modified charcoal has excellent stability and can be recycled, the production process is simplified, and the separation difficulty is reduced.

The invention belongs to the technical field of pharmaceutical analysis, and particularly relates to a method for separating, detecting and determining an initial raw material SM3 and impurities thereof of ibrutinib. The impurities comprise one or more of propionyl chloride, 3-chloropropionyl chloride and benzoyl chloride. A mobile phase is a phosphate buffer solution as a mobile phase A, acetonitrile is a mobile phase B, a chromatographic column adopts octadecylsilane chemically bonded silica as a filler, and linear gradient elution of high performance liquid chromatography is carried out after pre-column derivatization. And then, according to a chromatogram, an external standard method is adopted to calculate the impurities according to a peak area. The method has the characteristics of good separation degree, good durability, high sensitivity and good reproducibility.

The invention relates to the technical field of propionyl chloride production, in particular to an efficient purification device for propionyl chloride production, which comprises a support plate, the lower end of the support plate is fixedly connected with a plurality of support legs, the upper end of the support plate is fixedly connected with a reaction furnace, and the side wall of the reaction furnace is provided with an air inlet and an air outlet. The gas inlet is communicated with an inert gas pipe, a purifying box is fixedly connected to the position, at the gas outlet, of the outer side of the reaction furnace, a plurality of collecting openings are formed in the side wall of the purifying box, and a circulating box is fixedly connected to the lower end of the purifying box. Through the stirring assembly and the water curtain nozzle, the contact efficiency of gas and an alkaline solution is enhanced, the adsorption and dissolution speed of HC gas is increased, efficient gas purification is ensured, a liquid circulation system between the circulation box and the purification box effectively reduces consumption of the solution, cyclic utilization of resources is achieved, the operation cost is reduced, and the device is suitable for popularization and application. The operation is simple, and the occupied area of equipment is small.

This invention belongs to the field of functional coatings technology, specifically relating to a waterborne graphene electrothermal coating. The waterborne graphene electrothermal coating comprises component A, component B, and component C. Component A comprises: waterborne hydroxyl acrylic dispersion, deionized water, wetting and dispersing agent, leveling agent, and defoamer. Component B comprises: waterborne isocyanate curing agent and cosolvent. Component C comprises: amino-modified reduced graphene oxide, composite additive, dispersant, and deionized water. The composite additive is prepared by reacting 3,5-bis(tert-butyl)-4-hydroxyphenylpropionyl chloride sequentially with triethylenetetramine and epoxy-modified carbon nanotubes. The amino-modified reduced graphene oxide is prepared by reacting graphene oxide with N-aminoethyl-3-aminopropylmethyldimethoxysilane followed by reduction. The waterborne graphene electrothermal coating prepared by this invention exhibits excellent electrothermal performance and weather resistance.

The invention belongs to the technical field of pharmaceutical analysis, and particularly relates to a method for separating and determining ibrutinib SM3 and impurities thereof based on gas chromatography. The impurities comprise any one or more of acrylic anhydride, trichlorotoluene, propionyl chloride, 3-chloropropionyl chloride, benzoyl chloride, acrylic acid and benzoic acid; the ibrutinib SM3 and impurities jointly form a composition to be detected. According to the method, (5% phenyl)-diphenylmethylsiloxane is adopted as a chromatographic column of a stationary liquid, or other stationary liquids with the same polarity are adopted; the ibrutinib SM3 and impurities of the ibrutinib SM3 are separated by adopting temperature programming; the temperature programming setting is as follows: the initial temperature is 35 + / -5 DEG C and is maintained for 5 + / -1 minutes, and the temperature is raised to 210 + / -10 DEG C at the rate of 30 + / -5 DEG C / min and is maintained for 8 + / -2 minutes. The method provided by the invention can effectively separate, identify and quantify various related substances in ibrutinib SM3, and has the advantages of short separation time, strong specificity, high sensitivity and good durability.

The invention discloses an anti-aging rubber material and a preparation method thereof, and relates to the technical field of high polymer materials. When the anti-aging rubber material is prepared, 4, 4 '-diaminodiphenylamine and 3, 5-bis (tert-butyl)-4-hydroxybenzene propionyl chloride are subjected to a reaction to prepare an anti-aging agent; reacting the maleic anhydride grafted ethylene propylene diene monomer with an anti-aging agent to obtain modified ethylene propylene diene monomer; reacting the carboxylated carbon nano tube with 3-(diphenylphosphino) propylamine to prepare a pre-modified carbon nano tube; reacting the pre-modified carbon nano tube with 2-(3-chloropropyl)-4, 6-dimethyl-1, 3, 5-triazine, so as to obtain a modified carbon nano tube; mixing the modified ethylene propylene diene monomer, the modified carbon nanotubes, zinc oxide, stearic acid, carbon black, paraffin oil, sulfur, an accelerant TMTD and an accelerant M, and performing hot pressing to obtain the anti-aging rubber material. The anti-aging rubber material prepared by the invention has good anti-aging, flame-retardant, antistatic and mechanical properties.

The invention discloses a method for detecting a related substance 3-chloropropionic acid in osimertinib starting material 3-chloropropionyl chloride, which comprises the following steps: reacting a sample with C1-C6 alkyl primary amine to preferentially convert 3-chloropropionyl chloride into an amide derivative; then adding an acyl chloride reagent and an alcohol esterification reagent, so that 3-chloropropionic acid is subjected to esterification reaction; then adding organic alkali for neutralization to obtain a stable test solution; and finally analyzing and quantifying through gas chromatography. Through step-by-step derivatization design, the interference of the main component 3-chloropropionyl chloride is thoroughly eliminated by using the preferential reaction of C1-C6 alkyl primary amine, then 3-chloropropionic acid is subjected to esterification reaction, and hydrochloric acid generated in the reaction is completely neutralized by adding organic alkali, so that the hydrolysis of the target derivative methyl 3-chloropropionate is effectively inhibited, and the stability of the target derivative methyl 3-chloropropionate is ensured. The method has the advantages of strong anti-interference performance, high accuracy, high sensitivity (the limit of quantitation is less than or equal to 0.03%), simple operation and easy industrial application.

The invention discloses a hydrogen peroxide and salicylic acid double-response fluorescent probe as well as a preparation method and application thereof, and belongs to the technical field of fluorescent probes. The preparation method comprises the following steps: dissolving (E)-2-amino-6 '-(diethylamino)-4'-[2-((E)-1, 3, 3-trimethylindoline-2-subunit) ethylidene]-1 ', 2', 3 ', 4'-tetrahydrospiro [isoindoline-1, 9 '-xanthene]-3-ketone in anhydrous acetonitrile, adding NaH and DMAP, uniformly stirring, then adding 3-[6-(4, 4, 5, 5-tetramethyl-1, 3, 2-boron dioxolane-2-yl)-1, 2, 4-triazole-2-yl)-1, 3, 4-triazole-2-yl]-1, 3, 4-triazole-2-yl]-1, 3, 4-triazole-2-yl]-1, 3, 4-triazole-2- adding 2, 3-dioxo-1H-benzo [de] isoquinoline-2 (3H)-yl] propionyl chloride, and reacting to obtain the target fluorescent probe. According to the probe, H2O2 and SA recognition sites are orthogonally coupled to the same parent nucleus, so that it is ensured that all recognition units synchronously reach a target microenvironment at a constant stoichiometric ratio, high sensitivity and near-infrared emission characteristics are achieved, autofluorescence interference of plant tissues is effectively avoided, and the detection sensitivity is high. Accurate in-situ imaging and dynamic analysis of the space-time evolution process of H2O2 and SA in plant cells are achieved, and the method has wide application prospects in the fields of plant immunology, analytical chemistry, life science and the like.

This invention relates to a method for preparing the CYP11B2 inhibitor BAXDROSTAT. Specifically, this invention provides two preparation methods. Method 1: Baxdrostat is obtained by condensing 4-halo-6,7-dihydroisoquinoline-8(5H)-one with S-tert-butylsulfinamide aldehyde ketone, followed by reduction with sodium borohydride, then reaction with pinacol diboronate, followed by Suzuki coupling reaction, deprotection, and reaction with propionyl chloride. Method 2: The product (S)-N-(4-halo-6,7-dihydroisoquinoline-8(5H))-tert-butylsulfonylimide from step 2 of Method 1 is first deprotected, then reacted with 6-bromo-1-methyl-3,4-dihydroquinoline-2(1H)-one via Suzuki coupling reaction, and then reacted with allyl chloride.