The invention relates to the technical field of
chemical engineering, and discloses a production process of chloropropionyl
glutamine. The production process comprises following steps: carrying out acylating chlorination reaction: adopting D-2-chloropropionic acid and
thionyl chloride as raw materials, adopting DMF (N, N-
dimethylformamide) as a catalyst, and carrying out reaction to generate D-2-chloropropionyl
chloride,
sulfur dioxide and
hydrogen chloride. According to the production process of chloropropionyl
glutamine, 791kg of
thionyl chloride is pressed into a dry and clean 2000 L enamelreaction kettle by using
nitrogen, stirring is started, and 0.75kg of N, N-
dimethylformamide is slowly dropwise added; then, 600kg of D-2-chloropropionic acid is pressed into a dry and clean 1000L enamel high-level tank by using
nitrogen gas, a reaction kettle jacket is subjected to 75 DEG C hot water bath to increase the temperature of the
system to 60-65 DEG C, D-2-chloropropionic acid is dropwise added into the reaction kettle for about 4 h at 60 to 65 DEG C, and the
gas release amount is controlled by adjusting the dropwise adding speed. T production process is simple in steps, complete in reactant reaction, high in
raw material utilization rate and low in preparation cost, troubles of users are avoided, and the production process is convenient for users to use.