Novel process for preparing chloropropionyl chloride

Abstract

The invention discloses a novel process for preparing chloropropionyl chloride, which can overcome the defects that the byproduct phosphorous acid in the existing chloropropionyl chloride production process is not thoroughly separated and is not easy to treat and store; catalyst recycling is impossible to realize; the yield is low; the cost is high, and the like. According to the novel process, inthe acylation process, the product of the reaction of propionic acid and phosphorus trichloride is subjected to standing separation, the lower phosphorous acid is subjected to hydrolysis, decoloration, negative pressure distillation and slicing deep processing to reach the industrial standard of industrial phosphorous acid, the product at solid state is easy to store, byproducts are easy to sell,and extra economic benefits are brought to companies. A novel catalyst is used in the chlorination process of crude propionyl chloride at the upper layer, the catalyst is ideal in catalytic effect, can be repeatedly used, is not easy to carbonize at high temperature and has few residues, so that the quantity and the quality of products are improved.

Description

technical field [0001] The invention belongs to the technical field of organic synthesis, and in particular relates to a new process for preparing chloropropionyl chloride. Background technique [0002] Chloropropionyl chloride is an important raw material for organic synthesis. It is used in medicine to synthesize ibuprofen, and in pesticides to synthesize herbicides. Two reactions are mainly used in the process of preparing chloropropionyl chloride: acylation reaction and chlorination reaction. In the acylation process of the traditional production process of chloropropionyl chloride, the separation of phosphorous acid is not complete, the by-product phosphorous acid does not meet the industrial standards, and the phosphorous acid solution is not easy to handle and store; the liquid catalyst used in the chlorination process is easy to carbonize at high temperature and produces side effects. Reaction, subsequent residues are more difficult to handle and cannot be reused, a...

AI Technical Summary

Problems solved by technology

In the acylation process of the traditional production process of chloropropionyl chloride, the separation of phosphorous acid is not complete, the by-product phosphorous acid does not meet the industrial standards, and the phosphorous acid solution is not easy to handle and store; the liquid catalyst used in the chlorination process is easy to carbonize at high temperature and produces side effects. Reaction, the follow-up residue is more difficult to handle and cannot be reused, and the cost is higher