Continuous production method suitable for ibuprofen Friedel-Crafts reaction

Abstract

The invention provides a continuous production method suitable for an ibuprofen Friedel-Crafts reaction, which is characterized in that a chloropropionyl chloride complexing solution and a Friedel-Crafts reaction circulating solution are uniformly mixed in a static mixer to obtain a mixed solution, the mixed solution and isobutylbenzene enter a jet reactor at the same time, the mixed solution is used as a jet reactor driving flow, and the isobutylbenzene is used as a jet reactor driven flow; a chloroketone solution generated by the Friedel-Crafts reaction is continuously discharged through a circulating pump; according to the invention, the continuous production of the ibuprofen Friedel-Crafts reaction is realized, the automatic control is easy to realize, the safety of the system is improved, the labor intensity is reduced, the reaction retention time is shortened, and the production efficiency is improved by more than 5-10 times.

Description

technical field [0001] The invention relates to the field of chemical pharmacy, more specifically, to a continuous production method of ibuprofen Friedel-Crafts reaction. Background technique [0002] Ibuprofen is a non-steroidal antipyretic, analgesic, and anti-inflammatory drug. Its synthesis process is mainly divided into ketone process, ketal process, rearrangement and hydrolysis process, etc. As the first step reaction in the synthesis chain, the chlorketone process is the most important link in the synthesis chain, and the most critical part of the ketone process is the Friedel-Crafts reaction process. Controlling the Friedel-Crafts reaction is the key to ensuring the quality of ibuprofen products. [0003] At present, there are few researches or reports on the Fuckers reaction of ibuprofen in China, and there are few specific operating parameters. In the prior art, the Friedel-Crafts reaction of ibuprofen is produced in batch mode, that is, the complex solution gener...

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Problems solved by technology

Due to the traditional technology adopting the batch method, there are many manual operation steps, and the control of the reaction temperature is unstable, resulting in large fluctuations in the quality of each batch of products and low production efficiency. A production cycle takes about 5-8 hours; at the same time, in the traditional batch production method Reactor stirring cannot achieve rapid mixing, resulting in poor selectivity of isobutylbenzene reaction, and the content of the generated impurity ortho-chlorone is more than 3%, which affects product yield and quality; when the production load is large, by controlling the reaction kettle jacket The method of adjusting the reaction temperature by refrigerant cannot remove a large amount of reaction heat in a timely and effective manner, which may easily cause the reaction temperature to exceed the process requirements and affect product quality.

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