135 results about "L glutamate" patented technology

A complex is provided for the treatment of neurogenic conditions having the formula:

where R¹ is

M is a metal ion Ca(II), Mg(II), Cu(II) or Ni(II); n is an integer 1 or 2; R is BBB peptide, transferrin, membrane transporter peptide, TAT peptide, bradykinin, beta-endorphin, bombesin, calcitonin, cholecystokinin, an enkephalin, dynorphin, insulin, gastrin, substance P, neurotensin, glucagon, secretin, somatostatin, motilin, vasopressin, oxytocin, prolactin, thyrotropin, an angiotensin, galanin, neuropeptide Y, thyrotropin-releasing hormone, gonadotropnin-releasing hormone, growth hormone-releasing hormone, luteinizing hormone, vasoactive intestinal peptidegluconate, L-lactate, L-leucine, L-tryptophan, and L-glutamate; and R is coupled to M through a carboxylate moiety. Magnesium (II) represents the preferred metal ion as magnesium is known to have neuroprotective effects. The metal ion is in part chelated by a non-steroidal anti-inflammatory drug that does not inhibit platelet activity and includes salicylate and ibuprofenate. The complex also includes a ligand operative in transport across the blood brain barrier. A process for making an inventive complex includes the stoichiometric addition of ligands containing carboxylate groups to a solution of the metal ion. In instances where the metal ion is magnesium (II), a stoichiometric ratio of 1:1:1 is found between the non-steroidal anti-inflammatory ligand:magnesium (II):transporter ligand.

The present invention relates to the compositions that enhance post-exercise recovery processes to increase both strength and muscle mass, replace glycogen stores, and prevent inflammation, resulting in the prevention and/or reduction of delayed onset muscle soreness. Additionally, it provides a feeling of muscle relaxation as well as a feeling of mental tranquility immediately following exercise. The composition consists of any or all high-glycemic sugars and/or polysaccharides (e.g., sucrose, glucose, maltodextrin), all essential amino acids and beta-hydroxy-beta-methylbutyrate and can include other amino acids sources (e.g. whey protein), performance enhancing agents (e.g., caffeine, L-glutamate), anti-inflammatory agents (e.g., ginger, boswellia, curcumen), antioxidants (vitamin C, vitamin E, selenium, polyphenols,), insulin-mimicking agents (cinnamon, Banaba), analgesics (e.g. aspirin, ibuprofen, naproxen, acetaminophen), and to methods of treating humans and animals by administration of these novel compositions to humans and animals in need thereof.

The invention discloses a composition for preparing a camel milk facial mask, and particularly a composition for preparing a camel milk moisturizing skin-calming facial mask, a camel milk moisturizing clear facial mask, a camel milk moisturizing compact facial mask and a camel milk moisturizing conditioning facial mask according to functions. By virtue of the synergism of camel milk, water, sodium carbomer, glycerinum, xanthan gum, butanediol, sodium hyaluronate, poly(sodium L-glutamate), skin conditioner and preservative, the characteristics and advantages of the camel milk are maximally maintained, so that the composition for preparing the cameral milk facial mask has the advantages of the camel milk, namely, proteins, vitamins, minerals and fatty acid rich in the composition can provide rich nutrient substances for the skin and can improve the face skin; particularly, the camel milk contains lactoferrin and lysozyme which are short in cow milk, so that the composition has the effects of sterilizing, killing demodex, removing toxicity, softening stratum corneum epidermidis, moisturizing and tendering the skin, preventing wrinkles and aging resistance, and delaying senescence.

The invention provides a poly(L-glutamic acid) homopolymer which has a repeating unit disclosed as formula (I), and the number-average molecular weight of the poly(L-glutamic acid) homopolymer is 2000-40000. The invention also provides a preparation method of the poly(L-glutamic acid) homopolymer in the technical scheme above, which comprises the following step: polymerizing gamma-propinyl-L-glutamate-N-endo-carboxylic anhydride under the action of primary amine initiator to obtain the poly(L-glutamic acid) homopolymer. The invention provides a poly(L-glutamic acid) random copolymer, of whichthe structure is disclosed as formula (II) and the number-average molecular weight is 2000-80000. The invention also provides a preparation method of the poly(L-glutamic acid) random copolymer. The invention also provides a preparation method of a poly(L-glutamic acid) graft copolymer.

Production of alanyl glutamine dipeptide compound is carried out by adding L-glutamine into mixed liquid of methylbenzene and water, cooling, adding into sodium hydrate, dissolving L-glutamine, dripping into solution with alpha - halopropacyl halide, methylbenzene and sodium hydrate, regulating pH, reacting, separating organic layer, adding sodium chloride into solution with organic layer separation, regulating pH, adding into concentrated chlorhydric acid, regulating pH, laying aside, filtering, separating out crystal, drying crystal, reacting with ammonia water, controlling temperature and pressure, cooling, de-pressuring, concentrating, adding water, dripping into methyl alcohol, laying aside, filtering, separating out L-alanyl-L-glutamate crude products, purifying and obtaining refined products. It achieves simple process and low cost.

The invention provides poly (gamma-propargyl-L-glutamate)-polyamino acid segmented copolymer. The poly (gamma-propargyl-L-glutamate)-polyamino acid segmented copolymer is presented as the formula (I). Small molecules containing primary amino radical serve as an initiator, and the poly (gamma-propargyl-L-glutamate)-polyamino acid segmented copolymer is obtained through the gradual ring cleavage reaction of gamma- propargyl-L-glutamate-N-carboxylic acid anhydride and amino acid-N- carboxylic acid anhydride. The side chain of the segmented copolymer is propargyl which is easy to modify, has high reactivity and is beneficial to functional small molecules which are subjected to bonded azide and have biological activity or environmental responsiveness, and the bonding process cannot lead to the breakage of amino acid backbones and is not affected by the amount and steric hindrance of functional small molecules. The segmented copolymer has good biocompatibility after being functionalized and can be applied in fields such as targeted drug delivery, organizational projects and protein separation and detection.

A process of making a polylpeptide or a pharmaceutically acceptable salt thereof comprises reacting a L-lysine protected polypeptide, which comprises L-alanine, L-tyrosine, L-glutamate, and L-lysine that is protected with a protecting group, with a tetraalkylammonium hydroxide in water to remove the protecting group.

The present invention discloses one kind of gamma-aminobutyric acid producing lactobacillus brevis and its use. The lactobacillus brevis has preservatioin number of CGMCC No. 1306; exhibits pairs or chains; and has no motion, no spore, small colony and smooth surface. It belongs to Gram positive bacteria and facultative anaerobe, and may be used in producing gamma-aminobutyric acid. By means of biological synthesis process, the high activity glutamate decarboxylase connected in the lactobacillus brevis and sodium L-glutamate as substrate, the sodium L-glutamate is decarboxylated to produce gamma-aminobutyric acid and CO2. Thus produced gamma-aminobutyric acid is safe in food level.

A builder composition includes a chelating component A), a builder component B), a polymeric component C), and optionally an alkali component D) and/or a phosphorous-containing component E). The chelating component A) includes a1) methylglycine-N-N-diacetic acid (MGDA) and/or an alkali salt thereof, and/or a2) N,N-bis(carboxymethyl)-L-glutamate (GLDA) and/or an alkali salt thereof, and/or a3) ethylenediaminetetraacetic acid (EDTA) and/or an alkali salt thereof. The builder component B) includes b1) a metal silicate, and/or b2) a metal carbonate, and/or b3) a metal citrate. The polymeric component C) includes c1) an acrylic-maleic copolymer, and/or c2) polyacrylic acid (PAA).

The invention provides poly(gamma-propynyl-L-glutamate) block copolymer. The block copolymer contains a block A shown in the formula (I) and a block B shown in the formula (II). The poly(gamma-propynyl-L-glutamate) block copolymer is AB block copolymer, wherein the number average molecular weight of the block A is 550-10000, the number average molecular weight of the block B is 800-20000, and the weight percentage of the block B to the block copolymer is 25%-75%. The invention also provides a preparation method of the poly(gamma-propynyl-L-glutamate) block copolymer and poly(gamma-propynyl-L-glutamate) block copolymer hydrogel. Compared with the prior art, the block copolymer provided by the invention contains propynyl, thus the application range of the block copolymer can be expanded.

The invention relates to isolated nucleotide sequences from Coryneform bacteria which code for the pck gene encoding the enzyme phosphoenol pyruvate carboxykinase (PEP carboxykinase). The invention also relates a process for the fermentative preparation of L-amino acids, in particular L-lysine, L-threonine, and L-glutamate by attenuation of the pck gene.

The invention discloses a serum-free culture medium suitable for immune cell large-scale culture, and belongs to the field of cell biology and medical immunology. The serum-free culture medium takes an RPMI1640 culture medium as a basis, additive components are further contained and include HEPES, phenol red sodium salt, L-glutamate and sodium bicarbonate. Insulin, transferrin, selenium, human albumin and interleukin-2 can be further added. Components contained in the culture medium are chemical defined components, no animal serum components are contained, and the serum-free culture medium is suitable for large-scale culture of immunity cells and is high in clinical safety and good in proliferation effect.

The invention discloses a multi-effect skin-tendering mask which comprises the following components by weight: 67.55 parts of water, 4 parts of butanediol, 0.2 part of allantoin, 0.4 part of hydrolytic Sclerotium Gum, 0.1 part of disodium, 0.1 part of sodium hyaluronate, 0.15 part of poly(sodium L-glutamate), 3 parts of betaine, 5 parts of licorice extract, 8 parts of cherry blossom extract, 5 parts of North American witch hazel water, 0.5 part of oat seed extract, 2 parts of nicotinamide, 0.5 part of Aloe barbadensis Mill gel, 2.2 parts of beta-glucan, 0.5 part of isoascorbic acid, 2 parts ofglycerol caprylate, 4.5 parts of propylene glycol and 0.4 part of caprylhydroxamic acid. The multi-effect skin-tendering mask has the advantages of non-preservative formula and good skin-tendering effect, and is capable of effectively increasing skin moisturizing ability, promoting skin health, increasing skin transparency, enhancing skin immunity, making skin full and elastic, and making skin smooth and smooth.

The present invention relates to new compound diethyl 4-(4-oxobutyl) benzoyl-L-glutamate and its preparation process and application. The compound diethyl 4-(4-oxobutyl) benzoyl-L-glutamate in the chemical expression as shown is prepared through the reaction of compound diethyl 4-bromo benzoyl-L-glutamate and 3-butene-1-alcohol inside Nú¼N-dimethyl formamide solvent under the action of palladium acetate catalyst, weak alkali reagent, lithium halide and phase transfer catalyst in the protection of inert gas at 50-70 deg.c. The compound diethyl 4-(4-oxobutyl) benzoyl-L-glutamate is used in synthesizing diethyl 4-[(4-oxo-3-bromo) butyl] benzoyl-L-glutamate as the intermediate of Pemetrexed disodium. The present invention results in shortened Pemetrexed disodium synthesizing path and lowered production cost.

A cleaning composition comprises the reaction product of A) a chelating component and B) an acidic component different from the chelating component. The chelating component is selected from the group of methylglycine-N-N-diacetic acid (MGDA), N,N-bis(carboxymethyl)-L-glutamate (GLDA), nitrilotriacetic acid (NTA), hydroxyethylethylenediaminetriacetic acid (HEDTA), ethylenediaminetetraacetic acid (EDTA), diethylenetriaminepentaacetic acid (DTPA), and mixtures thereof. The chelating component is generally a salt or a partial-salt of the respective acid, e.g. Na₃.MGDA. The B) acidic component and the A) chelating component are reacted in a molar ratio (B:A) of from about 6:1 to about 1:6 to form the reaction product. The cleaning composition further comprises a surfactant component in addition to the reaction product. The cleaning composition is useful for removing and/or preventing spotting and filming on ware surfaces in a dishwater, such as for removing and/or preventing filming and/or spotting on cookware, bakeware, tableware, dishware, flatware, and/or glassware in an automatic dishwasher (ADW).

An ink jet textile printing ink composition includes water; a color material; and a metal chelating agent. In the ink composition described above, the metal chelating agent includes at least one selected from methyl glycine diacetic acid, L-glutamate diacetic acid, L-aspartic diacetic acid, hydroxyethylimino diacetic acid, 3-hydroxy-2,2′-iminodisuccucinic acid, dicarboxymethyl glutamic acid, (S,S)-ethylenediaminedisuccinic acid, and salts thereof, and the pH of the ink composition is 6 to 10.

The invention provides adriamycin nano-particles. The adriamycin nano-particles are prepared by compounding adriamycin and a block copolymer with a structure shown as a formula (I) or a formula (II) through electrostatic interaction. A preparation method for the adriamycin nano-particles comprises the following step of: electrostatically compounding the adriamycin and the block copolymer with thestructure shown as the formula (I) or the formula (II) in an aqueous medium to obtain the adriamycin nano-particles. In the aqueous medium, a poly(gamma-propargyl-L-glutamate-g-mercaptosuccinic acid)segment and a polyethylene glycol segment which are contained in the block copolymer wrap the adriamycin into cores of the nano-particles, so the adriamycin composite particles are high in stability.The nano-particles are expected to be gathered at tumor sites in blood circulation through an 'enhanced permeability and retention effect' so as to improve the targeting effect of the adriamycin on the tumor sites. Meanwhile, the electrostatic interaction between a carboxyl group of the block copolymer and an amino group of the adriamycin is easy to eliminate under the condition of low intracellular pH values, so that the intracellular release can be accelerated, and the medicinal effect can be improved.

The present invention relates to new compound diethyl 4-[(4-oxo-3-bromo) butyl] benzoyl-L-glutamate and its preparation process and application. The compound diethyl 4-[(4-oxo-3-bromo) butyl] benzoyl-L-glutamate in the chemical expression as shown is prepared through the reaction of material diethyl 4-(4-oxo-butyl) benzoyl-L-glutamate and bromo reagent inside C1-C4 halohydrocarbon solvent at 20-30 deg.c. The compound diethyl 4-[(4-oxo-3-bromo) butyl] benzoyl-L-glutamate is used as the important intermediate of antitumor medicine Pemetrexed disodium. The present invention provides new path of synthesizing Pemetrexed disodium, and results in shortened Pemetrexed disodium synthesizing path and lowered production cost.

The invention discloses a safe escherichia coli ZS-07 strain for high yield of Gamma-aminobutyric acid as well as a method for synthesizing Gamma-aminobutyric acid by utilizing the same, belonging to the field of biochemistry. The preservation number of the escherichia coli strain is CGMCC No.3562, and glutamate decarboxylase contained in the escherichia coli is acted on L-glutamic acid, L-glutamate or matters containing the L-glutamic acid or the L-glutamate to synthesize the Gamma-aminobutyric acid. The strain has the advantages of high glutamate decarboxylase activity and strong acid resistance, and the method has the advantages of mild reaction condition, fewer byproducts, simplicity, low cost and high production efficiency and is easy to operate. In addition, the Gamma-aminobutyric acid has high purity and can be used in the fields of chemical engineering, foods, feeds, medicines, and the like.

The invention provides a levorotatory VC snow skin factor-rich mask capable of improving the skin color and improving the brightness. The mask is prepared from the following raw materials in parts by weight: butanediol, glycerol, dipropylene glycol, a yeast extract, glycine betaine, royal jelly, a hydrolysed placenta (sheep) extract, ubiquinone, palmitoyl pentapeptide-4, collagen, glyceryl polyether-26, sodium hyaluronate, trehalose, poly(sodium l-glutamate), carbomer, xanthan gum, triethanolamine, phenoxyethanol, chlorphenesin, methylparaben, PEG-40, hydrogenated castor oil, essence and water. The traditional Chinese medicine extract is capable of effectively enhancing the effect of delaying senescence; the royal jelly can be absorbed by epidermis of a human body; the epidermis cells are nourished; the life vitality of the epidermis cells is promoted and enhanced; the metabolism of the skins is improved; elimination of metabolites is accelerated; pigmentation is reduced; and the elastic fiber is prevented from degenerating.

The N-alkylglycine trimeres (I), where R1, R2 and R3, independent of one another, are chosen from amongst cyclopropyl, sec-butyl, 2-metoxyethyl, 3-methylbutyl, cyclohexyl, 2-(N-pyrrolidinyl)ethyl, 2-(methylcarbonylamine)ethyl, 3-(2-oxo-N-pyrrolidinyl)propyl, 2-(2-pyridyl)ethyl, phenylethyl, 1-(2-tetrahydrofuryl)methyl, 2-(N-imidazolyl) ethyl, 2-(4-metoxyphenyl) ethyl, 2-(3,4-dimetoxyphenyl) ethyl, 2-(2,4-dichlorophenyl) ethtyl, 2-[2-(N-methyl) pyrrolidinyl] ethyl, 2-(4-aminosulfonylphenyl) ethyl, 2-(morpholine) ethyl, 3-(N,N-diethylamine) propyl, 3,3-diphenylpropyl, 3-(N,N-dimethylamine) propyl, and 2-(N,N-diethylamine) ethyl, their stereoisomeric forms and their mixtures, which are capable of blocking L-glutamate receptors and are useful for treating disorders mediated by said receptors.