16 results about "Vasopressin" patented technology

A benzazepine fused ring derivative as represented by formula (I) or a pharmaceutically acceptable salt thereof, and the use of a compound in the diagnosis, prevention and / or treatment of diseases related to vasopressin receptors.

The application provides a candidate drug for promoting embryo implantation efficiency of patients with uterine redox imbalance type RIF, and belongs to the technical field of embryo implantation. In order to solve the problem of how to find potential intervention drugs for the pathological mechanism of uterine redox imbalance type RIF, a five-step high-efficiency drug screening strategy based on an in-vitro implantation model of uterine redox imbalance type repeated embryo implantation failure is adopted to ensure the reliability and functional correlation of the screening results. The candidate drug screened by the five-step high-efficiency drug screening strategy includes any one of the following drugs: avobenzone, vasopressin, ethylenediaminetetraacetic acid dipotassium, larotrectinib sulfate, citicoline, opicapone, iclapa, L-leucine, fulvestrant, malic acid and lucotinib. Among these candidate drugs, avobenzone, vasopressin and ethylenediaminetetraacetic acid dipotassium are the best three drugs for promoting the implantation efficiency of patients with uterine redox imbalance type RIF.

The invention provides a candidate medicine for promoting the embryo implantation efficiency of a uterus redox imbalance type RIF patient, and belongs to the technical field of embryo implantation. In order to solve the problem of how to discover a potential intervention drug aiming at a uterine redox imbalance type RIF pathological mechanism, a five-step efficient drug screening strategy based on an in-vitro implantation model of uterine redox imbalance type repeated embryo implantation failure is adopted, so that the reliability and functional correlation of a screening result are ensured. A candidate drug screened by adopting a five-step method efficient drug screening strategy comprises any one of the following drugs: avobenzone, vasopressin, dipotassium ethylene diamine tetraacetate, lalotinib sulfate, citicoline, olprinone, eltrombopag, L-leucine, fulvestrant, malic acid and rucotinib. Among the candidate drugs, avobenzone, vasopressin and dipotassium ethylenediaminetetraacetate are three drugs with optimal implantation promotion efficiency for patients with uterine redox imbalance type RIF.

The application provides a use of a teriparatide acetate in preparation of a medicine for preventing and / or treating acute respiratory distress syndrome, and belongs to the technical field of medicines.The application finds that after a mouse with acute respiratory distress syndrome (ARDS) is injected with the teriparatide acetate, neutrophil infiltration can be effectively reduced, and lung hemorrhage, lung capillary hyperemia and lung capillary septum thickening and other lung injury symptoms can be reduced.In addition, the teriparatide acetate can effectively prevent the occurrence of ARDS, can reduce the lung injury degree of the mouse, can reduce the neutrophil infiltration, lung hemorrhage and lung capillary hyperemia and other symptoms, can reduce the level of inflammatory factors in serum, and can reduce lung edema.Therefore, the teriparatide acetate can not only be used for treating acute respiratory syndrome and acute lung injury, but also can prevent the occurrence and development of acute respiratory syndrome, has a remarkable effect, is high in safety, and has a wide application prospect.

The application belongs to the technical field of microorganisms, and provides a Streptococcus salivarius subsp. thermophilus HX-ST36, which has a preservation number of CGMCC NO. 32955. The Streptococcus salivarius subsp. thermophilus provided by the application can ferment Astragalus membranaceus Bunge-Angelica sinensis. In a cold coagulation and blood stasis type primary dysmenorrhea model mouse, the fermentation product thereof can significantly inhibit the writhing response, and can realize the effects of relieving dysmenorrhea and tonifying blood by reducing the levels of prostaglandin PGF2 and vasopressin ADH in uterine tissue and increasing the hemoglobin (HGB) content. The effect of the fermentation product in removing dampness is verified by improving the dampness signs of a crowd. The application further provides a probiotic preparation and a preparation method of a probiotic fermentation product. The preparation method of the probiotic preparation and the probiotic fermentation product is simple and can be produced on a large scale.

Provided is a system comprising a flexible container for intravenous administration which comprises a premix vasopressin pharmaceutical formulation, and uses thereof.

The benzazaspiro derivatives represented by formula (I) and pharmaceutically acceptable salts thereof, as well as the compounds, can be used for diagnosing, preventing and / or treating diseases associated with vasopressin receptors.

A peptide may include a sequence having 80% or more amino acid identity with the amino acid sequence of SEQ ID NO. 1, i.e., RPSX1CNLPVKPGPCX2GFFSAFYYSQKX3NKCHSFTYGGCAGNANRFSTX4EKCRRTC X5X6, wherein, X1 is the amino acid residue F or G, X2 is any amino acid residue, except a basic amino acid residue, X3 is the amino acid residue T or D, X4 is the amino acid residue I, L, or E, (i) X5 is V and X6 is G or (ii) X5 is G and X6 is V, and the amino acid located at position 39 is A. Such peptides may have various diagnostic and therapeutic uses.

The invention discloses a polypeptide compound as well as a preparation method, a pharmaceutical composition and application thereof. The compound (formula I) takes a vasopressin receptor V2R as a drug target, can effectively inhibit protein activity, has better receptor selectivity, half-life period and plasma stability, and is more beneficial to patent medicine. The application prospect is wide, and the compound can be applied to treatment and / or prevention of chronic kidney diseases, especially autosomal dominant hereditary polycystic kidney diseases. Meanwhile, the preparation method of the compound is high in universality and suitable for expansion of various structure types. # imgabs0 #

Benzazepine compounds, methods of making and medical uses thereof. In particular, compounds of Formula II-1 or Formula VIII-1 and pharmaceutical compositions containing the same, and medical uses thereof. The benzazepine compounds can be used for treating diseases associated with vasopressin receptors, in particular hypertension, heart disease, etc.

The present invention relates to a composition for the prevention, amelioration, or treatment of urination-related disases, comprising cephalotocin. The cephalotocin according to the present invention modulates oxytocin receptors and vasopressin receptors, and has the effect of reducing urine volume by promoting water reabsorption in the kidneys. This means that cephalotocin has a significant antidiuretic effect, and thus, the cephalotocin of the present invention can be variously used in the field of prevention, amelioration, or treatment of urinary disorders or urination-related diseases.

A clinical care system that integrates and analyzes patient data and applies rules to recommend potential treatments. A potential application is detection and management of shock, using hemodynamic data collected from devices such as a right heart catheter. The system may calculate confidence levels for each rule and present high-ranked treatment options to clinicians along with their confidence levels. Confidence levels for treatments may change continuously as a patient's condition evolves. For shock, features extracted from measured data may include for example a cardiac index (cardiac output divided by patient body surface area), systemic vascular resistance, and mean arterial pressure; treatment recommendations derived from these (and other) features may include administration of various medications such as epinephrine and vasopressin, installation of a ventricular assist device, transfusion, and volume resuscitation. Machine learning may be used to match recommendations to current clinical practice, or to optimize patient outcomes.

According to the composition with the effects of replenishing blood, clearing damp and dispelling cold and the preparation method thereof, hemoglobin peptide, fish collagen peptide, donkey-hide gelatin peptide and iron are utilized to form composite micelles, then vitamin C-rich Chinese wolfberry powder is utilized to be mixed, a mixture of lily and poria cocos powder is fermented by casei paracasei ID01 to serve as a wrapping network system, and the composition is prepared through the steps of preparing the composition with the effects of replenishing blood, clearing damp and dispelling cold. Meanwhile, a cross-linking agent is added for cross-linking, so that a polypeptide-iron-vitamin C-fermentation compound quaternary complex structure is formed. A slow-release system is evaluated by simulating a static digestive tract, so that targeted delivery and absorption optimization of iron elements are realized. In a cold coagulation and blood stasis type primary dysmenorrhea model mouse, the composition can significantly inhibit the writhing reaction, and can achieve the effects of enriching blood, clearing damp and dispelling cold by reducing the levels of prostaglandin PGF2 and vasopressin ADH in uterine tissues and increasing the content of hemoglobin HGB.

The application discloses a kind of 4-(trifluoro-2-hydroxypropyl)-1,2,4-triazolone derivatives and medical purposes thereof.A series of compounds provided by the application can be used as vasopressin V1a / V2 receptor antagonists as lead compounds, and are expected to be used for preparing drugs for treating heart failure and combinations thereof.

The present invention discloses a Chinese medicine composition for preventing and treating coronary heart disease and angina pectoris and a preparation method thereof, belonging to the field of Chinese medicine preparations. The Chinese medicine composition is prepared from 17 Chinese medicinal herbs: astragalus, codonopsis, rhodiola, poria, ophiopogon, schisandra, rehmannia root, polygonatum, epimedium, kudzu root, angelica, salvia miltiorrhiza, honeysuckle, kelp, kelp, oyster, and immature bitter orange. The composition of the present invention is well-matched and synergistic, and has the effects of invigorating qi and activating blood circulation, resolving phlegm and unblocking meridians. It is suitable for treating chest pain caused by qi and yin deficiency, phlegm and blood stasis, coronary heart disease, and angina pectoris, as well as pharmacodynamic tests. Pharmacodynamic tests show that the Chinese medicine composition of the present invention can significantly prolong the hypoxia tolerance time of mice, has a certain antagonistic effect on acute myocardial ischemia caused by vasopressin in rats, has a significant reducing effect on ST segment elevation caused by coronary artery ligation in rats, can significantly reduce the range of myocardial infarction caused by coronary artery ligation, and has a reducing effect on hyperlipidemia in rats fed a high-fat diet.