Azole derivatives

A technology of azole derivatives and medicinal salts, which is applied in the field of azole derivatives and can solve the problems of no reports of compounds with azole skeletons
CN103889951BActive Publication Date: 2016-12-14TAISHO PHARMACEUTICAL CO LTD
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
TAISHO PHARMACEUTICAL CO LTD
Publication Date
2016-12-14

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Abstract

The invention of the present application provides mood disorder, anxiety disorder, schizophrenia, Alzheimer's disease, Parkinson's disease, Huntington's disease, eating disorder, hypertension, digestive organ disease, drug dependence, epilepsy, cerebral infarction, Therapeutic or preventive agents for diseases such as cerebral ischemia, cerebral edema, head trauma, inflammation, immune-related diseases, and alopecia. Specifically, an azole derivative represented by the general formula (I) having an arginine vasopressin 1b receptor antagonistic activity, or a pharmaceutically acceptable salt thereof is provided. 【Chemical 1】
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Description

technical field

[0001] The present invention relates to an azole skeleton compound with antagonistic effect on the V1b receptor of arginine vasopressin (AVP) and a pharmaceutical composition using the compound as an active ingredient, in particular to emotional disorders (including depression), Anxiety disorder, schizophrenia, Alzheimer's disease, Parkinson's disease, Huntington's disease, eating disorder, hypertension, digestive organ disease, drug dependence, epilepsy, cerebral infarction, cerebral ischemia, cerebral edema, headache Therapeutic or preventive agents for external trauma, inflammation, immune-related diseases, alopecia and other diseases. Background technique

[0002] Arginine vasopressin (AVP) is a peptide composed of 9 amino acids, which is mainly biosynthesized in the hypothalamus. As a pituitary hormone, it is closely related to the regulation of plasma osmotic pressure, blood pressure and body fluid volume.

[0003] Three subtypes of AVP receptors, V1a,...

Claims

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