Novel benzoazepine compound, composition and applications of novel benzoazepine compound and composition

A compound and heterocyclic group technology, applied in the field of new benzazepine compounds, can solve the problems of insufficient activity, side effects and physicochemical properties
CN112851583APending Publication Date: 2021-05-28XUZHOU MEDICAL UNIV +1
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
XUZHOU MEDICAL UNIV
Publication Date
2021-05-28

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Abstract

The invention relates to a novel benzoazepine compound, which comprises a pharmaceutically acceptable salt thereof. The invention also provides a pharmaceutical composition containing the compound and the pharmaceutically acceptable salt thereof. The present invention also relates to the use of the compounds and said compositions in the prevention or treatment of diseases associated with the arginine vasopressin V1a receptor, the arginine vasopressin V1b receptor, the arginine vasopressin V2 receptor, the sympathetic nervous system or the renin-angiotensin-aldosterone system.
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Description

technical field

[0001] The present invention relates to novel benzazepine Compounds, compositions and uses thereof. Background technique

[0002] Arginine vasopressin (AVP) is a naturally occurring neurohormone that is released in the brain and blood. AVP plays an important role in regulating water, blood pressure and the secretion of pituitary adrenocorticotropic hormone (ACTH), and exerts its physiological effects by binding to specific G protein-coupled receptors in the central nervous system and some peripheral parts or tissues. and behavioral effects. In the brain, AVP regulates circadian rhythms, promotes learning and memory in the hippocampus, and plays an important role in regulating social behavior in neurobehavioral disorders through actions in the limbic circuit.

[0003] Three distinct AVP receptor subtypes have been identified on a pharmacological and functional basis: V 1a , V 1b and V 2 . These receptors are located in the liver, blood vessels (coronar...

Claims

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