Bis-sulfonamide compound and its preparation method and use

A compound and pharmaceutical technology, which is applied in its preparation method and in the fields of medicine, bissulfonamide compounds, and medicine, can solve the problems of benzazepine compound activity and insufficient physical and chemical properties of side effects, and achieve obvious antagonistic effects
CN103936713BActive Publication Date: 2016-01-20TIANJIN INSTITUTE OF PHARMA RESEARCH
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
TIANJIN INSTITUTE OF PHARMA RESEARCH
Publication Date
2016-01-20

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Abstract

The invention relates to bisulfamide compounds as well as a preparation method and use thereof, and specifically relates to bisulfamide compounds having the structure as shown in a formula I and pharmaceutically acceptable salts thereof as well as a preparation method of the bisulfamide compounds, pharmaceutical compositions with the bisulfamide compounds having the structure as shown in the formula I and the pharmaceutically acceptable salts thereof as active effective constituents and use of the pharmaceutical compositions in preventing or treating diseases associated with an arginine vasopressin V1a receptor, an arginine vasopressin V1b receptor, an arginine vasopressin V2 receptor, the sympathetic nervous system or the renin-angiotensin-aldosterone system; the formula I is as shown in the specification.
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Description

Technical field

[0001] The present invention belongs to the field of medical technology, and more specifically, relates to a class of bissulfonamide compounds, a preparation method thereof, and application in the medical field. Background technique

[0002] Arginine vasopressin (arginine vasopressin, AVP), also known as antidiuretic hormone, vasopressin, is a peptide hormone secreted by the pituitary gland, through the receptor-G protein-second messenger pathway, it regulates the body fluid balance And many other functions. AVP plays an important role in regulating the reabsorption of human free water, the isotonic concentration of body fluids, blood volume, blood pressure, cell contraction, cell proliferation and the secretion of adrenal cortex hormones.

[0003] Arginine vasopressin exerts various physiological effects by binding to vasopressin receptors. Vasopressin receptors can be divided into three subtypes: V1a, V1b and V2. V1a receptors are distributed in vascular smooth...

Claims

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