34 results about "Membrane Transporters" patented technology

A complex is provided for the treatment of neurogenic conditions having the formula:where R1 isM is a metal ion Ca(II), Mg(II), Cu(II) or Ni(II); n is an integer 1 or 2; R is BBB peptide, transferrin, membrane transporter peptide, TAT peptide, bradykinin, beta-endorphin, bombesin, calcitonin, cholecystokinin, an enkephalin, dynorphin, insulin, gastrin, substance P, neurotensin, glucagon, secretin, somatostatin, motilin, vasopressin, oxytocin, prolactin, thyrotropin, an angiotensin, galanin, neuropeptide Y, thyrotropin-releasing hormone, gonadotropnin-releasing hormone, growth hormone-releasing hormone, luteinizing hormone, vasoactive intestinal peptidegluconate, L-lactate, L-leucine, L-tryptophan, and L-glutamate; and R is coupled to M through a carboxylate moiety. Magnesium(II) represents the preferred metal ion as magnesium is known to have neuroprotective effects. The metal ion is in part chelated by a non-steroidal anti-inflammatory drug that does not inhibit platelet activity and includes salicylate and ibuprofenate. The complex also includes a ligand operative in transport across the blood brain barrier. A process for making an inventive complex includes the stoichiometric addition of ligands containing carboxylate groups to a solution of the metal ion. In instances where the metal ion is magnesium(II), a stoichiometric ratio of 1:1:1 is found between the non-steroidal anti-inflammatory ligand:magnesium(II):transporter ligand.

The invention relates to a gene capable of regulating and controlling inhibition of vitamin C fermented strain acid production during acid stress and belongs to the technical fields of basic research on vitamin C prepared by fermentation and biological engineering. The key gene for regulating and controlling yield reduction of acid stress induced 2-KLG in the production strains is determined, so a metabolic engineering strategy with high pertinence is generated. The expression condition of genes, in particular membrane transport protein genes, of specific microorganisms in the microorganisms subjected to mixed cultivation is analyzed by an expression profile chip technology. Compared with ketogenic gulonic acid bacteria subjected to single cultivation, the ketogenic gulonic acid bacteria subjected to mixed bacteria cultivation have 45 upregulated membrane transport protein genes and 15 downregulated membrane transport protein genes. The notable thing is that: 7 iron ion transport protein genes are inhibited to express. After acid stress, the iron ion transport protein genes are overexpressed. During fermentation, the iron ions are added to inhibit mixed bacteria to ferment and generate acid. The result shows that the iron ion transport protein exerts reverse action in the process of yield reduction of 2-KLG generated by the acid stress induced mixed bacteria fermentation.

Cell suicide (apoptosis) is associated with pathogenesis, for example, it is the major cause for the loss of neurons in Alzheimer's disease. Caspase-3 is critically involved in the pathway of apoptosis. Superantibody (SAT)-trans-membrane technology has been used to produce antibodies against the caspase enzyme in an effort to inhibit apoptosis in living cells. The advantage of using trans-membrane antibodies as apoptosis inhibitors is their specific target recognition in the cell and their lower toxicity compared to conventional apoptosis inhibitors. It is shown that a MTS-transport-peptide modified monoclonal anti-caspase-3 antibody reduces actinomycin D-induced apoptosis and cleavage of spectrin in living cells. These results indicate that antibodies conjugated to a membrane transporter peptide have a therapeutic potential to inhibit apoptosis in a variety of diseases.

The invention discloses a recombinant genetically engineered bacterium and its application to produce vanillin by fermentation. The genes of vanillin or ferulic acid include one or more of the periplasmic membrane fusion protein AcrA gene, the inner membrane transport protein AcrB gene or the outer membrane protein TolC gene; the host includes the large intestine containing the ech gene and the fcs gene bacilli. The recombinant genetically engineered bacteria E.coli BW25113::PegYB::pACYCDuet-acrAB-tolC of the present invention can use ferulic acid as a substrate to produce vanillin, and the highest yield of vanillin is 2335 mg / L. The fermented liquid fermented by the method of the invention contains higher vanillin and has good application prospects.

The invention relates to the technical field of microbes, and discloses Lactobacillus plantarum for preventing and / or treating periodontitis, its culture and its preparation and application. The Lactobacillus plantarum, named Lactobacillus plantarum (Lactobacillus plantarum) CCFM1137, was preserved on August 1, 2020 at the Guangdong Provincial Microbial Culture Collection Center on the 5th Floor, Building 59, Compound No. 100, Xianlie Middle Road, Guangzhou City, and the preservation number is GDMCC No: 61114. The plantarum lactobacillus can inhibit the formation of Porphyromonas gingivalis, Prevotella intermedia and Fusobacterium nucleatum mixed bacteria biofilm; it can reduce the content of inflammatory factors in the periodontitis cell model; it can make the periodontitis cell model The expression level of the transmembrane transport protein is increased; it can be used for preventing and / or treating oral diseases and inhibiting Prevotella intermedium, Porphyromonas gingivalis and / or Fusobacterium nucleatum.

The invention discloses a transferring and cutting tool for a nano light filtering film. According to the nano film storage and cutting tool, the effect that the nano film is safely and reliably stored can be ensured; complete cutting of the nano film can be finished at a time in a specified shape; burrs, cracks and defects do not exist; a step spigot and a circular arc spigot are designed, double-spigot laminating is formed, and the problem that a nano material cannot be pressed when an upper pressing frame and a lower pressing frame are laminated can be solved; unsafe factors in a tool cavity can be eliminated during transferring of the nano light filtering film by designing an upper protection cover; and a boss of the upper protection cover is attached to the light filtering film, thus, an attachment stabilizing effect is achieved, and the safety of the light filtering film is protected.

The invention belongs to the technical field of medicine application, and discloses an application of trametinib in preparing a medicine for reversing multi-medicine resistance of tumors. Trametinib can be used for significantly reversing the multi-medicine resistance of the tumors mediated by membrane transport protein to ensure that the sensitivity of P-glycoprotein high expression cells to anti-cancer medicines can be restored. According to the medicine for reversing the multi-medicine resistance of the tumors, disclosed by the invention, trametinib and the anti-cancer medicines can be combined to ensure that the effects of treating and controlling resistant tumors can be achieved by restoring the sensitivity of resistant cells to the anti-cancer medicines.