The invention discloses a preparation method of a
sacubitril intermediate, which comprises the following steps: adding a
metal nickel salt and a chiral diphosphine ligand into a
solvent in a
nitrogen atmosphere at
room temperature, and stirring to react for 0.5-6 hours to prepare a
nickel catalyst solution; and under the
nitrogen atmosphere, sequentially adding a compound (II), the prepared
nickel catalyst solution, a
solvent and an additive into a high-pressure kettle, reacting for 6-30 hours at the temperature of 20-100 DEG C and the
hydrogen pressure of 1.0-6.0 MPa, after the reaction is finished, carrying out vacuum concentration to remove the
solvent, and recrystallizing and purifying residues to obtain the
sacubitril intermediate (I), the dr value of the
sacubitril intermediate can reach 99 / 1, and the
stereoselectivity can reach 99% ee. Compared with the prior art, the method provided by the invention has higher implementation value and social and
economic benefits, and has the characteristics of high
atom economy, small green
pollution, easiness in industrialization and the like.