Poly(L-glutamic acid) homopolymer, random copolymer and graft copolymer, and preparation methods thereof

A technology of random copolymer and graft copolymer is applied in the fields of poly(L-glutamic acid) homopolymer, random copolymer, graft copolymer and their preparation, and can solve the problems of small application range and the like, Achieve the effects of no toxic side effects, good biocompatibility and degradability, and broad application prospects
CN102093554AActive Publication Date: 2011-06-15CHANGZHOU INST OF ENERGY STORAGE MATERIALS &DEVICES
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
CHANGZHOU INST OF ENERGY STORAGE MATERIALS &DEVICES
Publication Date
2011-06-15

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Abstract

The invention provides a poly(L-glutamic acid) homopolymer which has a repeating unit disclosed as formula (I), and the number-average molecular weight of the poly(L-glutamic acid) homopolymer is 2000-40000. The invention also provides a preparation method of the poly(L-glutamic acid) homopolymer in the technical scheme above, which comprises the following step: polymerizing gamma-propinyl-L-glutamate-N-endo-carboxylic anhydride under the action of primary amine initiator to obtain the poly(L-glutamic acid) homopolymer. The invention provides a poly(L-glutamic acid) random copolymer, of whichthe structure is disclosed as formula (II) and the number-average molecular weight is 2000-80000. The invention also provides a preparation method of the poly(L-glutamic acid) random copolymer. The invention also provides a preparation method of a poly(L-glutamic acid) graft copolymer.
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Description

technical field

[0001] The invention relates to the technical field of poly(L-glutamic acid), in particular to a poly(L-glutamic acid) homopolymer, a random copolymer, a graft copolymer and a preparation method thereof. Background technique

[0002] Polyamino acid polymers have good side group modification, biodegradability, biocompatibility and regular secondary structure, and are widely used in biomedical fields, such as bioseparation, tissue engineering, gene therapy and drug controlled release, etc. . Among them, poly(L-glutamic acid) is a polyamino acid with carboxyl groups in the side chain, and its side carboxyl groups have good reactivity, which is convenient for functional modification, so that poly(L-glutamic acid) can be further functionalized, It has a good application prospect in the field of intelligent biomedical materials.

[0003] The functional modification of poly(L-glutamic acid) is mainly carried out by condensation reaction, as Biomacromolecules (Vol....

Claims

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