Poly(gamma-propynyl-L-glutamate) block copolymer and preparation method and hydrogel thereof

A technology of block copolymers and glutamate, which is applied in drug delivery, pharmaceutical formulations, medical preparations of non-active ingredients, etc., can solve problems such as unfavorable hydrogel applications, and achieve long-lasting bioactive molecule release capabilities, Good biocompatibility and the effect of expanding the application range
CN102167818AActive Publication Date: 2011-08-31CHANGZHOU INST OF ENERGY STORAGE MATERIALS &DEVICES
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
CHANGZHOU INST OF ENERGY STORAGE MATERIALS &DEVICES
Publication Date
2011-08-31

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Abstract

The invention provides poly(gamma-propynyl-L-glutamate) block copolymer. The block copolymer contains a block A shown in the formula (I) and a block B shown in the formula (II). The poly(gamma-propynyl-L-glutamate) block copolymer is AB block copolymer, wherein the number average molecular weight of the block A is 550-10000, the number average molecular weight of the block B is 800-20000, and the weight percentage of the block B to the block copolymer is 25%-75%. The invention also provides a preparation method of the poly(gamma-propynyl-L-glutamate) block copolymer and poly(gamma-propynyl-L-glutamate) block copolymer hydrogel. Compared with the prior art, the block copolymer provided by the invention contains propynyl, thus the application range of the block copolymer can be expanded.
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Description

technical field

[0001] The invention belongs to the technical field of poly(L-glutamic acid) derivatives, and in particular relates to a poly(γ-propynyl-L-glutamate) block copolymer, a preparation method thereof and a hydrogel. Background technique

[0002] Stimulus-sensitive hydrogel is a three-dimensional network composed of hydrophilic polymers, which can sense small changes in the external environment, such as temperature, pH value, ionic strength, biomolecules, chemicals, photoelectricity and magnetic field, etc. The expansion and contraction of its own volume or the occurrence of sol-gel transitions respond to external stimuli, and it has broad application prospects in drug control release, substance separation and purification, bioactive substance embedding, and tissue engineering culture.

[0003] Injectable hydrogel is a kind of stimulation-sensitive hydrogel. Before being injected into the human body, it is a polymer aqueous solution. After being injected into the ...

Claims

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