Method for preparing alanyl-glutamine injection

Abstract

The invention belongs to the technical field of medicine preparation, and in particular relates to a method for preparing an alanyl-glutamine injection. The method comprises the following steps: (1) adding 30 percent by prescription of injection water and alanyl-glutamine by prescription into a concentrated preparation tank, stirring until the raw materials are completely dissolved, adding wet injection activated carbon, stirring and adsorbing, pumping into a diluted preparation tank, washing the concentrated preparation tank in a fractional manner with 10-60 percent by prescription of injection water, and drawing all the washing water into the diluted preparation tank; (2) filling injection water to 90 percent of the prescription amount after the liquid medicine in the concentrated preparation tank is drawn, regulating the pH value to 5.5-6.3 with a pH value regulating agent, adding the wet injection activated carbon, filling the injection water to full dose, circulating the drawing action for 30-40 minutes; (3) filling, sterilizing and sub-packaging. Compared with the prior art, the alanyl-glutamine injection prepared by the method is safe, reliable and good in stability.

Description

technical field

[0001] The invention belongs to the technical field of medicine preparation, and in particular relates to a preparation method of alanyl glutamine injection. Background technique

[0002] Glutamine is a conditionally essential amino acid. It is the most abundant free amino acid in the human body and an important nitrogen carrier and donor. It is also the main energy source for rapid metaplastic cells such as intestinal epithelial cells and lymphocytes in the body. It helps to maintain the shape of the intestinal tract and the function of the immune system. It is an important precursor substance for the synthesis of nucleic acids, proteins, purines, pyrimidines, etc., and is also a regulator of protein synthesis and decomposition. However, due to glutamine's low water solubility and instability in solution, it can generate toxic glutamic acid and ammonia during heat sterilization, so it cannot be directly used as a drug. Only by converting it into stable deriv...

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