The invention relates to an orthopaedic osteosynthesis plaster for treating bone fracture, and a making method thereof. The orthopaedic osteosynthesis plaster can effectively solve the medication problem of bone fracture, and is prepared from, by weight, 45-55 parts of rhizoma drynariae, 45-55 parts of borax, 45-55 parts of Chinese angelica root, 20-30 parts of Boswellia carteri, 20-30 parts of myrrh, 45-55 parts of Himalayan Teasel Root, 45-55 parts of natural copper, 45-55 parts of rheum officinale, 45-55 parts of ground beetles, 45-55 parts of safflower, 45-55 parts of Herba Speranskiae Tuberculatae, 45-55 parts of Whiteback Greenbrier rhizome, 45-55 parts of Ligusticum wallichii, 20-30 parts of panax notoginseng, 20-30 parts of Bletilla striata and 20-30 parts of lumbricus. The plaster has a good treatment effect on early fracture disunion, traumatic injuries, sprains, bone fracture and other orthopaedic diseases, and ankylosis, ischemic necrosis of femoral head and other bone fracture sequelae, has no toxic effects, realizes the treatment of both manifestation and root cause of disease, and is an innovation of bone fracture treatment plasters.