6 results about "Decreased immune function" patented technology

The invention belongs to the technical field of experimental animal models, biomedical research and immunology, and discloses a photocoagulation thymus ischemia animal model, a method and application of the photocoagulation thymus ischemia animal model in rapid simulation of thymus degeneration and immune senescence, and the model shows at least one or more characteristics 1-7 days after induction: thymus atrophy, thymus weight or thymus index is significantly reduced; the cortical-medullary structure of thymus is disordered or disappears; the expression distribution of the Keratin 5 / Keratin 8 is abnormal; thymic cell apoptosis is increased, and lipid deposition is enhanced; the proportion of CD4 + CD8 + double positive T cells is reduced, and the proportion of DN2 / DN3 stage T cells is increased; the initial T cell output is reduced; and the immune function is reduced. The pathological mechanism is clear; the modeling period is short, and the immune senescence phenotype can be stably obtained within several days; the injury focus is controllable, and systemic stress or hormone interference is avoided; the model has high repeatability and is suitable for mechanism research and drug screening.

The invention relates to a probiotic fermented plant beverage capable of improving immunity and a preparation method thereof, and belongs to the technical field of medicated food. The preparation method comprises the following steps: crushing American ginseng, astragalus membranaceus, rhizoma polygonati, poria cocos and malt, adding functional components and selenium-enriched water, mixing and stirring, and sterilizing to obtain a fermentation substrate; the preparation method comprises the following steps: respectively carrying out strain activation, centrifugation and freeze drying on dry casei, lactobacillus acidophilus, casei rhamnosus and lactobacillus plantarum, and then mixing to obtain composite probiotic powder; culturing the obtained composite probiotic powder in an MRS culture medium to obtain a composite probiotic liquid; and inoculating the composite probiotic liquid into the obtained fermentation substrate for fermentation, carrying out solid-liquid separation, taking a liquid phase, and sterilizing to obtain the probiotic fermented plant beverage capable of improving immunity. Aiming at the problems of immune function decline and blood sugar fluctuation after high-intensity exercises of sports people, the activity and absorption efficiency of nutritional ingredients are enhanced through probiotic fermentation, and accurate nutritional support is provided for body recovery after exercises.

The invention discloses application of a xanthoceras sorbifolia extract in preparation of a medicine for preventing and / or treating electromagnetic radiation damage. Experiments show that the xanthoceras sorbifolia bunge flower extract can improve the weight loss of rats caused by microwave radiation; brain tissue structure change damage caused by microwave radiation is improved; the reduction of the learning and memory ability of the rats caused by microwave radiation is improved; the brain sea horse tissue amino acid neurotransmitter disorder caused by microwave radiation is improved; electroencephalogram alpha and beta wave abnormity caused by microwave radiation is improved; the sperm motility reduction caused by microwave radiation is improved; the rat serum sex hormone disorder caused by microwave radiation is improved; rat testicular tissue oxidative stress injury caused by microwave radiation is improved; the abnormal energy metabolism of testicular tissues caused by microwave radiation is improved; heart electrophysiological abnormality and heart tissue ultrastructure abnormality caused by microwave radiation are improved; the immune function decline caused by microwave radiation is improved; the influence of microwave radiation on the content of IL-2, 4 is improved; the influence of microwave radiation on the thymus and spleen tissue structure is improved.

The application discloses application of CREG1 protein in preparation of medicines or reagents for inhibiting hematopoietic stem cell aging, and belongs to the field of biological medicines. The application first finds that the CREG1 protein has the function of inhibiting hematopoietic stem cell aging (including inhibiting hematopoietic stem cell proliferation abnormality, maintaining hematopoietic stem cell resting state, reducing hematopoietic stem cell DNA damage, and weakening hematopoietic stem cell myeloid differentiation tendency). Therefore, the CREG1 protein has the prospect of being developed into the medicines or reagents for inhibiting hematopoietic stem cell aging, and also has the prospect of being developed into the medicines for improving the immune function decline, anemia, bone marrow hypofunction or blood system diseases caused by hematopoietic stem cell aging.

To provide novel agents for suppressing decreased immune function that can be taken inexpensively, safely, and daily and effectively improve decreased immune function caused by aging and the like.SOLUTION: The present invention provides an agent for suppressing decreased immune function, which contains wheat bran and is used to promote the production of immunoglobulin A. The agent of the present invention is preferably used, for example, to promote the production of immunoglobulin A in a state in which immunoglobulin A secretion is reduced. Furthermore, the present invention provides an agent for suppressing decreased immune function, which contains wheat bran and is used to suppress the production of interleukin-6. In these agents, preferably the wheat bran is heat-treated wheat bran.SELECTED DRAWING: Figure 1

The invention belongs to the technical field of fermented food, and particularly relates to application of a ginseng fermentation liquor of phytobacterium plantarum HCS03-001 in a product for improving immunity. The preparation method of the ginseng fermentation liquor comprises the following steps: adding water into ginseng, extracting twice, combining extracting solutions, adding isomaltooligosacharide, and sterilizing to obtain a substrate; the preparation method comprises the following steps: activating and culturing the phytobacterium plantarum HCS03-001, inoculating a substrate, fermenting, and centrifugally sterilizing supernate to obtain a finished product, so that Rg3 can be efficiently enriched, the activities of macrophages and T cells are remarkably improved, and an immune pathway is doubly activated, thereby having the effects of reducing the risk of latent infection and delaying the decline of age-related immune functions. The product can be used for assisting postoperative or post-illness body function recovery, preventing / reducing infection and improving the immunosuppression state, can be prepared into food, health care products or medicines, is high in safety, provides an efficient and natural immunoregulation scheme for people with low immunity, and is suitable for industrial production and market transformation.