5results about How to "Reduce proteinuria" patented technology

The present invention provides a Chinese medicine composition for treating IgA nephropathy and a preparation method thereof, and belongs to the technical field of Chinese medicine compositions. The Chinese medicine composition of the present invention comprises raw rehmannia, astragalus, caesalpinia, codonopsis, radix rehmanniae, ophiopogon, plantago, tuckahoe, scutellaria, umbellate, motherwort, bupleurum, oldenlandia diffusa, scutellaria barbata, caulis scabra, radix scutellariae, radix scutellariae, radix licorice. The present invention also provides a preparation method of the Chinese medicine composition, comprising: weighing the raw materials according to the raw material ratio, decocting with water, and filtering to obtain a medicinal liquid. The composition provided by the present invention has a mild medicinal property, clears the heart fire, replenishes qi and yin, has no toxic side effects, can effectively reduce hematuria, proteinuria and adverse drug reactions, and is used for the treatment of chronic glomerulonephritis (IgA nephropathy).

This invention discloses the application of a PDLIM2 gene overexpression viral vector in the preparation of drugs for treating podocyte disease, wherein the nucleotide sequence of the PDLIM2 gene is shown in SEQ ID NO:1. This invention is the first to discover and verify the core role of the PDLIM2 gene in podocyte protection, confirming its significant downregulation in DKD and FSGS disease models, and demonstrating through functional experiments that PDLIM2 overexpression can effectively stabilize the podocyte cytoskeleton, inhibit apoptosis, and reduce proteinuria, thus establishing it as a key target gene for the treatment of podocyte disease. This invention is the first to intervene at the gene level in the core link of podocyte damage—cytoskeleton stability. By specifically upregulating the expression of PDLIM2 in podocytes, it directly enhances their intrinsic cytoskeleton support and anti-damage ability, achieving a fundamental shift in treatment strategy from "symptomatic support" to "causal repair."

The invention discloses application of a PDLIM2 gene overexpression virus vector in preparation of a medicine for treating podocytosis. The nucleotide sequence of a PDLIM2 gene is as shown in SEQ ID NO: 1. The core effect of the PDLIM2 gene in podocytosis protection is found and verified for the first time, it is confirmed that the expression of the PDLIM2 gene in DKD and FSGS disease models is remarkably reduced, and functional experiments prove that the overexpression of the PDLIM2 can effectively stabilize podocytoskeleton, inhibit apoptosis and relieve proteinuria, so that the PDLIM2 gene is determined as a key target gene for treating podocytosis. According to the invention, the stability of the cytoskeleton, which is a core link of podocyte injury, is intervened from the gene level for the first time. The expression of the PDLIM2 in the podocyte is specifically up-regulated, so that the internal cytoskeleton support and damage resistance of the podocyte are directly enhanced, and the fundamental treatment strategy conversion from symptomatic support to cause repair is realized.

The invention relates to the technical field of traditional Chinese medicine, in particular to a traditional Chinese medicine composition for treating IgA nephropathy proteinuria, a pharmaceutical preparation and a preparation method thereof. The traditional Chinese medicine composition is prepared from the following components in parts by weight: 35 to 45 parts of radix astragali seu hedysari, 35 to 45 parts of rhizoma dioscoreae, 25 to 35 parts of tortoise plastron, 25 to 35 parts of corn stigma, 25 to 35 parts of semen coicis, 10 to 20 parts of fructus ligustri lucidi and 10 to 20 parts of herba ecliptae. According to the present invention, the astragalus membranaceus is adopted as the monarch drug, and is matched with the Chinese yam, the tortoise plastron, the corn stigma, the coix seed, the glossy privet fruit and the eclipta according to the specific ratio, such that the kidney reinforcing and turbidity removing effects are provided, and the kidney function can be improved, the kidney can be protected, and the kidney damage can be prevented while the IgA nephropathy proteinuria can be treated.

The invention relates to the technical field of traditional Chinese medicine preparations, and particularly discloses a traditional Chinese medicine composition for treating diabetic nephropathy and application thereof. The traditional Chinese medicine composition is prepared from the following ten medicinal materials according to a specific ratio: radix rehmanniae recen, astragalus membranaceus, golden cypress, coptis chinensis, gastrodia elata, cicada slough, salvia miltiorrhiza, chinaroot greenbrier, rosa laevigata michx and motherwort. Systematic animal experiments and clinical researches prove that the Zuogui blood-glucose-reducing kidney-pleasing formula can effectively reduce fasting blood-glucose of diabetic nephropathy model mice, improve lipid metabolism disorder, remarkably reduce the levels of urea nitrogen, creatinine and uric acid and the ratio of urine protein to creatinine, and can be used for treating diabetic nephropathy by inhibiting expression of fibrosis-related factors such as TGF-beta and alpha-SMA. The renal fibrosis process is delayed. Compared with the prior art, the pharmaceutical composition provided by the invention has remarkable advantages in the aspects of improving renal functions, inhibiting renal tissue fibrosis and delaying the development of diabetic nephropathy.