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Application of N6-(2-ethoxy)adenosine in renal failure resistance

A technology of hydroxyethyl and renal failure, applied in the field of medicine, can solve problems such as not being disclosed

Active Publication Date: 2014-12-03
ZHEJIANG CHENGYI PAHRMACEUTICAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, the anti-renal failure active ingredients in cicadae have not been revealed. In order to better develop and utilize the anti-renal failure and kidney-protecting effects of Cordyceps and other Cordyceps, the anti-renal failure active ingredients in Cordyceps and other Cordyceps were discovered of great significance

Method used

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  • Application of N6-(2-ethoxy)adenosine in renal failure resistance
  • Application of N6-(2-ethoxy)adenosine in renal failure resistance
  • Application of N6-(2-ethoxy)adenosine in renal failure resistance

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Embodiment Construction

[0031] The specific embodiment of the present invention is only used as a specific embodiment of the present invention to illustrate the direct proof of the novel functions of the compounds mentioned in the present invention, but this is not a limitation of the present invention.

[0032] 1. Materials and methods

[0033] 1.1 Materials

[0034] 1.1.1 Animals: 28 male C57BL / 6 mice (Shanghai Slack Experimental Animal Co., Ltd.), with a mass of 20-25g, the experimental animal production license number is SCXK (Shanghai) 2012-0002, and the animal quality certificate number is SCXK (Shanghai) 2012-0002.

[0035] 1.1.2 Main reagents and instruments

[0036] Sodium pentobarbital was purchased from sigma; N6-(2-hydroxyethyl) adenosine, fetal bovine serum was purchased from Sijiqing; calf serum albumin; sheep serum was purchased from Beijing Suo Laibao Biotechnology Co., Ltd.; DAB work The solution was purchased from Beijing Zhongshan Jinqiao Biotechnology Co., Ltd.; Proteinase K wo...

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Abstract

The invention provides application of N6-(2-ethoxy)adenosine in preparation of preparations for treating renal failure. By virtue of the N6-(2-ethoxy) adenosine, levels of inosine and urea nitrogen in renal failure and renal ischemia reperfusion injury can be obviously reduced, and renal tubular epithelial cell apoptosis and kidney inflammations are inhibited. The N6-(2-ethoxy) adenosine can be applied to multiple treatment applications of renal failure, renal transplant, renal ischemia reperfusion injury, kidney stone lithotripsy inflammations and other nephritides.

Description

technical field [0001] The invention belongs to the field of medicine, in particular, it belongs to the application of an active substance (or artificially synthesized active substance) proposed from Cordyceps citridioides and other Cordyceps fungi for the protection of renal failure or renal ischemia-reperfusion injury. Background technique [0002] Ophiocordyceps sobolifera belongs to the entomogenous fungus, parasitic on cicada nymphs, it is the fungus that the cicada (Platilomia pieli koto) was killed in the soil before eclosion (the anamorph was once named peacilomyces cicadae) Parasitic, and finally at a place close to the ground about 3-4cm, the head grows a complex of cicadas and fungi formed by fruiting bodies. Its medicinal use was first recorded in "Lei Gong Pao Shao Lun" in the Southern and Northern Dynasties, compared with Cordyceps sinensis (O. sinensis) 800 years earlier. Tang Shenwei's "Jingshi Zhenglei Beiji Materia Medica" states that "Cicada flowers are s...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7076A61P13/12A61P29/00
CPCA61K31/7076
Inventor 柴一秋彭秀秀朱碧纯金轶伟
Owner ZHEJIANG CHENGYI PAHRMACEUTICAL
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