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New Application of Alkaloid Compounds of Fritillaria sichuanensis

A technology of alkaloids and compounds, which can be used in steroids, drug combinations, medical preparations containing active ingredients, etc., and can solve problems such as no reports of drug effects.

Inactive Publication Date: 2011-12-21
SICHUAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Chuan Fritillaria is one of the most commonly used Fritillaria medicinal materials, and the 2010 edition of Pharmacopoeia included Fritillaria unibracteata Hsiao et K.C.Hsia var.wabuensis (S.Y.Tang.et S.C.Yue) Z.D.Liu, S.Wang et S.C.Chen Loading the source of Chuan Fritillaria, Mo Zhengji and other studies have found that the 70% ethanol extract of Wabu Fritillaria has good effects such as antitussive, expectorant and bronchial expansion (Mo Zhengji, etc., Chinese Journal of Traditional Chinese Medicine, 1998 23 Volume 1, pp. 14-16), at present, there is no report on the efficacy of the total alkaloids of Fritillaria wabu, and there is no report on the monomeric alkaloids in Fritillaria sibetine, Reports on antitussive, expectorant and anti-inflammation effects of ketones, sibekine nitrogen oxides, isobekine and isobekine nitrogen oxides

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  • New Application of Alkaloid Compounds of Fritillaria sichuanensis
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  • New Application of Alkaloid Compounds of Fritillaria sichuanensis

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Embodiment 1

[0042] Embodiment 1 The preparation method of Wabu Fritillaria extract of the present invention

[0043] Take an appropriate amount of Fritillaria wabu, crush it, pass through a 60-mesh sieve, soak it with 10% ammonia water for 24 hours, put it in a reflux extraction device and use chloroform-methanol (4:1) to reflux and extract it 3 times, each time for 3 hours. Concentrate under reduced pressure and recover the extract to obtain a brown extract. Then place the extract in a vacuum oven and dry at 45°C for 72 hours to obtain the extract. The total alkaloid content of Wabu Fritillaria extract is 19.7%.

[0044] The amount of ammonia water used during the infiltration of the present invention is based on the fact that the liquid surface can cover the medicinal material to be extracted.

Embodiment 2

[0045] Embodiment 2 The preparation method of Wabu Fritillaria extract of the present invention

[0046] Take an appropriate amount of Fritillaria wabu, crush it, pass through a 60-mesh sieve, infiltrate it with 10% ammonia water for 2 hours, put it in a reflux extraction device and extract it with chloroform-methanol (2:1) reflux three times, each time for 3 hours. Concentrate under reduced pressure and recover the extract to obtain a brown extract. Then place the extract in a vacuum oven and dry at 45°C for 72 hours to obtain the extract. The total alkaloid content of Wabu Fritillaria extract is 15.7%.

Embodiment 3

[0047] Embodiment 3 The preparation method of Wabu Fritillaria extract of the present invention

[0048] Take an appropriate amount of Fritillaria wabu, crush it, pass through a 60-mesh sieve, infiltrate it with 10% ammonia water for 10 hours, put it in a reflux extraction device and use chloroform-methanol (4:3) to reflux and extract 3 times, each time for 3 hours. Concentrate under reduced pressure and recover the extract to obtain a brown extract. Then place the extract in a vacuum oven and dry at 45°C for 72 hours to obtain the extract. The total alkaloid content of Wabu Fritillaria extract is 10.3% in terms of Sibetine.

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Abstract

The present invention discloses the use of Fritillaria fricarifolia alkaloid compounds represented by general formula I in the preparation of antitussive, expectorant and / or anti-inflammatory drugs, wherein R1 is: =O or R2 is: H; R3 is: H; R4 is H or OH; R5 is: O or none. Among them, Sibetine, Tribenidone, Sibetine Nitrogen Oxides, Isofibesine, Isofibesine Nitrogen Oxides and 10 times the amount of codeine phosphate have similar antitussive effects, and the 5 The antitussive and anti-inflammatory effects of this monomer are also superior to peiminine and peiminine; among them, peiminine, peiminine, sibenetine, sibemine nitrogen oxide, and isobeamine Nitrogen oxides have a good expectorant effect. The invention also discloses the total alkaloid extract of Fritillaria wabu and its preparation method and application. Formula I

Description

technical field [0001] The invention relates to a new application of alkaloid compounds of Fritillaria sichuanensis, and also relates to an extract of Fritillaria chinensis and a pharmaceutical composition containing the extract, belonging to the field of medicines. Background technique [0002] Cough is a symptom of respiratory disease, often accompanied by sputum and inflammation. At present, most antitussive drugs will bring unavoidable side effects (addiction), and there is a lack of effective and safe medicines for treating cough. In traditional Chinese medicine, there are a large number of medicines for treating cough. Compared with synthetic medicines, these medicines have the advantages of good curative effect, low toxicity and few side effects. Therefore, it is a very valuable research path to find safe, effective and less side effect drugs in traditional Chinese medicine. [0003] Fritillaria has long been one of the classic Chinese medicines used by the Chinese ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/58A61P29/00A61P11/10A61P11/14C07J71/00
Inventor 王曙王冬冬冯莉
Owner SICHUAN UNIV
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