Slow-releasing bFGF-PLGA microball and its prepn and use
A microsphere and slow-release technology, which can be used in pharmaceutical formulations, medical preparations containing active ingredients, peptide/protein components, etc., and can solve the problems that there are no bFGF microspheres.
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[0013] Take 150 mg of PLGA and other auxiliary materials and dissolve it in an organic solvent to make an oil phase. The organic solvent is dichloromethane (DCM) or a mixture of dichloromethane (DCM) and acetone (AC), and the volume percentage of DCM and AC is 75-100:0-35. A 100 μg sample of bFGF was dissolved in double distilled water to form an aqueous phase. The bFGF solution is added to the above-mentioned oil phase and homogenized to form colostrum. Weigh an appropriate amount of PVA or PVA+PEG into double distilled water, make it fully dissolved in a water bath at 50°C, and adjust its concentration to 6%. Inorganic salt is added to the aqueous dispersion medium solution so that the concentration of the outer aqueous phase is 2% or higher. Add the above emulsion dropwise to 2ml of PVA or PVA-PEG solution, homogenize again, pour this solution into 8ml of the same concentration of PVA or PVA-PEG solution, and magnetically stir for 3-5 hours at room temperature to obtain bFGF-PL...
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