58 results about "Polylactide co glycolide" patented technology

The invention provides a composition for changing plasticity of bone meal particles as well as a preparation method and application of the composition, and relates to the technical field of biomedical materials. The composition is prepared from the following raw material components: bioactive glass, dihydrazide modified sodium hyaluronate, sodium hyaluronate with the molecular weight of 50kDa to 500kDa, a polylactic acid-glycolic acid copolymer and carboxymethyl cellulose. The preparation method of the dihydrazide modified sodium hyaluronate comprises the following steps: carrying out carboxyl activation on sodium hyaluronate, carrying out a cross-linking reaction on the activated hyaluronic acid and adipic dihydrazide, and then terminating the reaction. The composition provided by the invention not only can provide support, but also can adjust the degradation rate to be matched with the bone regeneration period, and all the components synergistically improve the mechanical property and the viscoelastic property. The composition disclosed by the invention can be formed in situ at a bone defect part, provides a space for growth and proliferation of bone cells, improves the biological activity and osteoinductivity of an artificial bone, and promotes bone growth and repair.

The application discloses a water-soluble quantum dot nanometer material and a preparation method and application thereof, and the nanometer material comprises quantum dots and carboxyl-terminated poly(lactic-co-glycolic acid) coated on surfaces of the quantum dots. The carboxyl-terminated poly(lactic-co-glycolic acid) is used for encapsulating CsPbBr3 perovskite quantum dots, and a water-soluble perovskite nanocrystal material is prepared, which can retain high quantum yield (PLQY=88%) and water-oxygen resistance (>=30 days) and almost completely retains optical performance of the perovskite quantum dots.

The invention provides a long-acting microsphere sustained release preparation and a preparation method thereof, and belongs to the technical field of sustained release preparations, the long-acting microsphere sustained release preparation is prepared from the following raw materials of effective components: 9.5 to 10.5 parts of antipsychotic drug, 48 to 50 parts of hydroxypropyl-beta-cyclodextrin, 50 to 52 parts of polylactic acid-glycolic acid copolymer, 1.25 to 1.3 parts of glycerol triacetate and 10 to 11 parts of polyvinyl alcohol. The preparation method comprises the following steps: firstly, the hydroxypropyl-beta-cyclodextrin is used for clathration of the antipsychotic drug, the obtained clathrate compound is further clathrated by the polylactic acid-glycolic acid copolymer, and the long-acting microsphere sustained release preparation is obtained. According to the invention, the double-valve design of beta-CD and PLGA synergistic inclusion is utilized, so that the preparation can realize two-stage release; the macroscopic slow release characteristic of the PLGA is combined with the microcosmic express characteristic of the hydroxypropyl-beta-cyclodextrin, so that the technical limitation of a single carrier is broken through.

The invention discloses a hair-growing liniment and a preparation method thereof, and belongs to the technical field of pharmacy. The liniment comprises the following components in percentage by weight: 1-10% of minoxidil microspheres, 5-20% of a film-forming agent, 0.5-5% of a polypeptide compound, 5-30% of a liquid auxiliary material and the balance of deionized water. Wherein the minoxidil microspheres are of a three-layer structure composed of minoxidil in the inner layer, nano enzyme (cerium dioxide) in the middle layer and lactic acid-glycolic acid ester copolymer or chitosan in the outer layer, and controlled release and targeted delivery are achieved; the polypeptide compound is a compound of oldenlandia diffusa polypeptide and a copper curcumin derivative, and has the effect of synergistically repairing a hair follicle microenvironment. Tests prove that the liniment can remarkably prolong the release time of minoxidil, increase the retention volume of minoxidil in hair follicle parts and reduce absorption of the whole body, shows a hair growth promoting effect superior to that of a traditional preparation and a single-layer microsphere preparation in an animal model, and has good stability and use comfort.

The invention belongs to the technical field of medicine preparation, and particularly relates to an anti-HIV infection compound medicine microsphere composition, a medicine preparation and application. The invention firstly provides an anti-HIV (Human Immunodeficiency Virus) infection compound drug microsphere composition, which is composed of Cabotegravir, rilpivirine and at least one polylactic acid-glycolic acid copolymer, and comprises a first compound microsphere composition or a second compound microsphere composition, wherein one of the microsphere compositions is a co-coated microsphere formed by co-coating Cabotegravir and rilpivirine in the same microsphere; and the other microsphere composition is a mixture consisting of a microsphere for wrapping Cabotegravir and a microsphere for wrapping rilpivirine. The invention aims to provide a flexible preparation platform so as to optimize the long-acting treatment effect of the two anti-HIV drugs. For a composition form that one microsphere wraps two medicines, synchronous release and long-acting release of the two medicines are realized as much as possible; for another physically mixed composition form, independent regulation of release kinetics of a single drug is achieved as much as possible, so that the same administration cycle is achieved. The pharmaceutical preparation disclosed by the invention can be used for prevention before HIV exposure and long-term maintenance treatment of infected persons, and can be used for remarkably improving medication compliance and reducing the risk caused by virus drug resistance.

The invention relates to the technical field of medical biological materials, and particularly discloses a composite electret flexible biological electrostatic electret patch and a preparation method thereof.The electrostatic electret patch comprises a backing layer, a medical pressure-sensitive adhesive layer and a functional layer which are sequentially arranged from outside to inside. According to the functional layer, at least one of polylactic acid, polyvinylidene fluoride and a polylactic acid-glycolic acid copolymer is selected as a polymer matrix to be compounded with graphene, a specific process combining ultrasonic dispersion and high-precision 3D printing is adopted, a deep-energy-level charge trap is introduced, the problems of high-conductivity filler agglomeration and surface charge leakage are solved, and the conductivity of the graphene is improved. The surface potential retention rate of the material can reach 60% or above after 900 days, the charge loss rate is not larger than 20% after 8-hour air exposure, and efficient physical electrostatic electret assisted sleep treatment under the drug-free and non-transdermal conditions is achieved.

A nanodiamond-reinforced nanofiber scaffold system for skin regeneration, consisting of a multilayered, electrospun nanofiber matrix formed from one or more biocompatible polymers selected from polycaprolactone (PCL), poly(lactic-co-glycolic acid) (PLGA), chitosan, gelatin or collagen, wherein nanodiamonds are present in an amount of 0.1 to 5 wt.-% are incorporated and surface-functionalized with oxygen, hydroxyl, or carboxyl groups to ensure homogeneous dispersion within the polymer matrix, the scaffold being characterized by a controlled fiber diameter in the range of 100 to 800 nm, an interconnected porosity between 60 and 90%, a tensile strength of 2 to 10 MPa, a degradation time of 2 to 8 weeks, and the ability to improve cell adhesion, proliferation, and migration of fibroblasts and keratinocytes, while simultaneously exhibiting antioxidant activity, reduced formation of reactive oxygen species, and the optional incorporation of bioactive agents selected from growth factors, antioxidants, or antimicrobial compounds to accelerate wound healing and skin tissue regeneration.

The invention relates to the technical field of modified calcium carbonate, in particular to modified calcium carbonate, which comprises the following structures: an inner core: lithium battery recycled calcium carbonate slag, which comprises 1.2-1.8 wt% of Li2CO3 and 0.5-1.2 wt% of MgCO3; the middle layer is a polydopamine (PDA) coating film, the thickness of the polydopamine (PDA) coating film is 50-80 nm, and the polydopamine (PDA) coating film is used for providing active amino (-NH2); the shell is a fluorine-containing silane and polylactic acid-glycolic acid copolymer (PLGA) composite layer, the grafting rate is larger than or equal to 90%, and the molar ratio of lactic acid to glycolic acid of PLGA is 75: 25. Quantized data of performance improvement and dispersibility are as follows: the oil absorption value is 18 ml / 100 g (compared with 28-32 ml / 100 g in the prior art), and the bulk density is 0.25 g / cm < 3 > (loose agglomeration). Functions are as follows: flame retardance: the oxygen index (LOI) reaches 34.5% (no flame retardance exists in the prior art); the antibacterial property is that the Escherichia coli inhibition rate is 99.2% (ASTM E2149 standard), and the environmental protection property is that 2.8 tons of limestone can be reduced for each ton of products, and 1.2 tons of CO2 emission can be reduced.

The invention belongs to the technical field of biomedical materials and targeted drug delivery systems, and discloses a targeted controlled-release drug delivery system based on a polymer nano-carrier and a preparation method thereof.The system is of a three-layer structure and comprises a core layer formed by taking polyvinyl alcohol as a matrix and used for efficiently entrapping a drug, and an outer layer formed by taking polyvinyl alcohol as a matrix and used for efficiently entrapping the drug; the shell layer formed by the polylactic acid-glycolic acid copolymer is used for providing structural stability and slow release capability, and the shell layer formed by the polyvinyl alcohol-hydroformylated glucan grafted copolymer is used for realizing microenvironment response release. And the surface of the shell layer is covalently modified with a tumor membrane targeting aptamer and a microenvironment response peptide, so that accurate recognition and local trigger release can be realized. The system has good particle size stability, responsive release ability and tumor cell targeted enrichment effect, and is suitable for efficient delivery and controlled release of various antitumor drugs.

This invention discloses a method for preparing a 3D-printed hydrogel scaffold for cartilage repair, comprising: providing methacrylamide chitosan; providing 2-([1,1-biphenyl]-4-ylcarbamoyl)benzoic acid@polylactic acid-glycolic acid copolymer microspheres; obtaining a 3D-printed bio-ink for cartilage repair using methacrylamide chitosan, 2-([1,1-biphenyl]-4-ylcarbamoyl)benzoic acid@polylactic acid-glycolic acid copolymer microspheres, recombinant collagen CF-1552, and lithium magnesium silicate as main raw materials; and obtaining a 3D-printed bio-ink for cartilage repair using the 3D-printed bio-ink for cartilage repair as a raw material to obtain a 3D-printed hydrogel scaffold for cartilage repair. This 3D-printed hydrogel scaffold has advantages such as antibacterial properties and the ability to promote the differentiation of human bone marrow mesenchymal stem cells (hBMSCs) into chondrocytes, and can be used for cartilage repair, potentially bringing new curative opportunities for cartilage injury diseases.

This invention discloses a biodegradable, highly bioactive magnesium bone particle, its preparation method, and its applications, belonging to the field of biomedical materials technology. Using magnesium bone particles as a matrix, an active composite coating layer comprising biodegradable polymer components and inorganic phase components is formed on its surface to construct biodegradable, highly bioactive magnesium bone particles. The biodegradable polymer components are one or more selected from polycaprolactone, polylactic acid, polylactic-co-glycolic acid copolymer, polyhydroxyalkanoates, chitosan, and their derivatives; the inorganic phase is one or more selected from hydroxyapatite, titanium dioxide, calcium phosphate materials, and combinations thereof. The preparation method includes magnesium bone particle matrix preparation, active composite layer slurry preparation, magnesium bone particle coating, and post-treatment. The prepared biodegradable, highly bioactive magnesium bone particles exhibit good degradation regulation performance and excellent bioactivity, and can be used in bone tissue engineering, bone defect repair, and scaffold filling fields.

The invention relates to an anti-inflammatory and lipid-lowering-based nano preparation for treating fatty liver and a preparation method of the nano preparation. Galactose modified polyethylene glycol-polylactic acid-glycolic acid copolymer (PEG-PLGA) is used as a targeting carrier, and a lipid-lowering drug fenofibrate and an anti-inflammatory drug curcumin are co-loaded; the particle size of the nano preparation is 150-200nm, and the drug encapsulation efficiency is greater than or equal to 85%. Galactose modified PEG-PLGA is adopted as a carrier, galactose can be specifically combined with an asialoglycoprotein receptor (ASGPR) specifically expressed on the surface of liver cells, active targeting of the liver is achieved, the drug enrichment amount of the liver lesion position is remarkably increased, meanwhile, accumulation of drugs in extrahepatic tissue is reduced, extrahepatic toxicity is effectively reduced, and the drug delivery effect is improved. According to the present invention, the anti-inflammatory drug curcumin and the fenofibrate are combined, such that the biological safety of the preparation is improved, the lipid lowering drug fenofibrate and the anti-inflammatory drug curcumin are innovatively co-loaded, and the fenofibrate and the anti-inflammatory drug curcumin form the synergistic effect system: fenofibrate can activate peroxisome proliferator-activated receptor alpha (PPAR alpha), promote liver lipid catabolism, and reduce lipid deposition;

The present invention provides compositions comprising peptide-coupled biodegradable poly(lactide-co-glycolide) (PLG) particles. In particular, PLG particles are surface-functionalized to allow for coupling of peptide molecules to the surface of the particles (e.g., for use in eliciting induction of immunological tolerance).

This invention relates to nanospheres for targeted removal of senescent cells in diabetic wounds and their preparation method. The nanospheres of this invention are galactose-modified PLGA-loaded Fe3O4 nanospheres. Polylactic acid (GAL) is grafted onto the surface of polylactic acid-glycolic acid copolymer (PLGA) microspheres to form a GAL-PLGA complex. Fe3O4 is encapsulated within the complex to form Fe3O4-loaded nanospheres. When the microspheres are engulfed and enter senescent cells in the diabetic wound, they enter lysosomes. Utilizing the increased β-galactosidase activity in senescent cells, the surface GAL can be degraded by the increased activity of β-galactosidase, selectively and slowly releasing the Fe3O4 encapsulated within the microspheres into the senescent cells. The free iron ions generated in the acidic microenvironment of the lysosome induce ferroptosis in the senescent cells, thereby achieving the goal of targeted removal of senescent cells in diabetic wounds.

The application relates to a sustained-release microneedle of water-soluble medicine and a preparation method thereof. The sustained-release microneedle of water-soluble medicine comprises a backing layer and a needle body arranged on the surface of the backing layer, the needle body comprises a needle tip, the material of the needle tip comprises water-soluble medicine and a polymer material, the polymer material comprises a combination of polylactic acid-glycolic acid copolymer with a mass ratio of (80-99):(1-20) and polylactic acid, the polylactic acid-glycolic acid copolymer comprises first polylactic acid-glycolic acid copolymer with a molecular weight of 60kDa-120kDa and second polylactic acid-glycolic acid copolymer with a molecular weight of 10kDa-40kDa, and the mass ratio of the first polylactic acid-glycolic acid copolymer to the second polylactic acid-glycolic acid copolymer is (1-6):1. The sustained-release microneedle can realize the sustained release of water-soluble medicine, avoid burst release, and simultaneously has good needle-forming property and mechanical property.

Disclosed in the present invention are a novel artificial bone based on promoting neurovascular regeneration and a preparation method. The novel artificial bone comprises an artificial bone. The artificial bone is composed of β-tricalcium phosphate, polylactic acid-glycolic acid, a nano magnesium-based powder, and a piezoelectric polymer. The mass ratio of β-tricalcium phosphate to polylactic acid-glycolic acid in the artificial bone is 1:0-1:10. The nano magnesium-based powder and the piezoelectric polymer are mixed to form a piezoelectric composite solution, and the mass ratio of the nano magnesium-based powder to the piezoelectric polymer in the piezoelectric composite solution is 1:1-1:20, such that the surface of the artificial bone is modified by means of the piezoelectric composite solution, thereby forming a piezoelectric coating on the surface of the artificial bone; in this way, when the artificial bone is implanted into a bone defect site and is subject to stress, a charge and potential difference are generated. The present invention not only enhances the strength of the artificial bone, but also promotes the degradation of the artificial bone, stimulates local neurovascular regeneration, promotes the formation of new bone, and achieves the purpose of repairing osteonecrosis and bone defects.

The invention discloses a preparation method and application of bionic nano immunomodulatory bait, and the preparation method comprises the following steps: firstly, obtaining neutrophils, treating the neutrophils with a cell lysis buffer solution containing a calcium ion chelating agent and a protease inhibitor, collecting supernate, and then centrifuging and purifying to obtain neutrophils membranes; then mixing an organic phase containing a polymer polylactic acid-glycolic acid copolymer and a therapeutic drug with a polyvinyl alcohol solution, and emulsifying to obtain a PLGA-therapeutic drug nano core; and finally, co-extruding the material and the neutrophile granulocyte membrane. The neutrophile granulocyte membrane is used as a camouflage shell, the nano bait capable of efficiently targeting an inflammatory site and neutralizing multiple inflammatory mediators is constructed, the nano bait is applied to brain injury after cardio-pulmonary resuscitation, efficient and active targeting on an inflammatory brain area can be achieved, the death rate of neurons can be reduced, and the nano bait has an extremely good application prospect.

The invention belongs to the technical field of traditional Chinese medicine preparations, and relates to a traditional Chinese medicine composition for treating beriberi. The invention discloses a traditional Chinese medicine composition for treating beriberi, which is a compound nano-particle spray and comprises compound nano-particles prepared from folium artemisiae argyi, dandelion, oriental wormwood, motherwort, rhizoma nardostachyos, radix angelicae extract and lactic acid-glycolic acid copolymer (PLGA) in specific parts by weight. The traditional Chinese medicine composition can effectively inhibit and kill trichophyton rubrum and destroy a fungal biofilm so as to achieve the effect of treating beriberi.

The application provides a kind of double-loading microcapsule containing pyraclostrobin and brassinolide and its preparation method and application, and the double-loading microcapsule includes core material and wall material, and the wall material covers the core material;The core material includes pyraclostrobin and 24-epibrassinolide, and the wall material includes polylactic acid-hydroxyacetic acid copolymer and hydroxypropyl methyl cellulose phthalate, and the mass ratio of polylactic acid-hydroxyacetic acid copolymer, hydroxypropyl methyl cellulose phthalate is (40-50):(90-100);The application uses polylactic acid-hydroxyacetic acid copolymer and hydroxypropyl methyl cellulose phthalate with suitable mass ratio as wall material, combined with the preferred preparation method, so that the drug loading of microcapsule and the drug encapsulation efficiency are high, the drug diffusion rate can be effectively controlled, the sustained-release effect is good, and the double-loading microcapsule particle size is suitable, the effective period is long, and the preparation method is simple, so that the prepared double-loading microcapsule particle size distribution is uniform, without damage and coating phenomenon.

The invention relates to the technical field of nitrogen fertilizers, in particular to a rice synergistic nitrogen fertilizer and a preparation method thereof. The invention overcomes the defects of low nitrogen fertilizer utilization rate and serious nitrogen loss in the use of the existing rice synergistic nitrogen fertilizer. The synergistic nitrogen fertilizer is obtained by performing double-layer coating on the nitrogen fertilizer, and the core component comprises urea and ammonium chloride; the inner layer film comprises the following components: corn starch, citric acid, dialdehyde starch, theophylline, dicyandiamide, sodium humate, glycerol and polyvinyl alcohol; the outer layer membrane comprises the following components: oxidized sodium alginate, a polylactic acid-glycolic acid copolymer, nano silicon dioxide, chitosan oligosaccharide, nano montmorillonite, thiourea and polyethylene glycol; wherein the oxidized sodium alginate is prepared from sodium alginate and sodium periodate, the prepared synergistic nitrogen fertilizer is good in slow release performance and small in nitrogen loss and can be used as a synergistic nitrogen fertilizer for rice, and the yield of crops is increased.

The invention discloses application of a composite biological material in hernia repair surgery, and belongs to the technical field of biotechnology, the composite biological material comprises a nanofiber scaffold, the scaffold is prepared by compounding polylactic acid-glycolic acid and silk fibroin, the weight ratio of the polylactic acid-glycolic acid to the silk fibroin is 70: 30, and the weight ratio of the polylactic acid-glycolic acid to the silk fibroin is 20: 30. The nanofiber scaffold is prepared through an electrostatic spinning technology and is used for providing mechanical support and promoting cell attachment and proliferation; the fiber is of a porous structure, the pore size is 10-100 microns, and cell permeation and nutrient substance exchange are facilitated; the polylactic acid-glycolic acid / silk fibroin composite scaffold is prepared by compounding polylactic acid-glycolic acid and silk fibroin, the mechanical properties of natural tissues are simulated, and a good growth scaffold is provided for cells. The gel layer is prepared through a solution phase separation method, and provides additional biological activity support and a cell attachment surface for the nanofiber scaffold. By arranging the antibacterial coating, the risk of postoperative infection is reduced, and meanwhile, protection is provided for materials and human tissues.

This invention discloses a method for preparing a high-concentration cyanide wastewater treatment agent. The method includes the following steps: mixing coal gangue and tourmaline, crushing and grinding the mixture, and passing it through a sieve of 1000 mesh or higher to obtain a coal gangue / tourmaline mixed powder; dissolving polyacrylamide in water to obtain a polyacrylamide solution with a concentration of 3-8 wt%; then ultrasonically dispersing the obtained coal gangue / tourmaline mixed powder in the polyacrylamide solution to obtain a suspension; adding a cationic monomer and an initiator to the obtained suspension to carry out a polymerization reaction to obtain copolymer I; adding polylactic acid-glycolic acid copolymer microspheres and a crosslinking agent to the obtained copolymer I, stirring the reaction, and after the reaction is completed, washing and drying the product to obtain the high-concentration cyanide wastewater treatment agent. The treatment agent of this invention can effectively remove high-concentration cyanide.

The invention relates to a poly-L-lactic acid microsphere used for a drug delivery system and having a controllable degradation rate and a preparation method and application thereof.The preparation method comprises the steps that an oil-phase organic solution is added into an emulsifier aqueous solution through an SPG film to be stirred for a reaction, and a poly-L-lactic acid microsphere crude product is obtained; sequentially mixing and reacting the L-polylactic acid microsphere crude product with a sodium hydroxide solution and a polylysine solution, washing and freeze-drying to obtain L-polylactic acid microspheres; a solute in the oil-phase organic solution comprises poly-L-lactic acid and a lactic acid-glycolic acid-polyvinyl alcohol block copolymer. The poly-L-lactic acid microsphere material obtained through a specific preparation process has good stability and biocompatibility, is controllable in degradation rate, and is suitable for preparing a drug delivery system, so that the drug curative effect is improved, and the drug administration frequency is reduced.

Approximately spherical lactic acid-glycolic acid copolymer (PLGA) microparticles include a biologically active substance. An average volume-based particle diameter of the PLGA microparticles is 1 μm or more and 150 μm or less. A Reactive Span Factor (R.S.F.) of the PLGA microparticles is satisfied with formula (1): 0.1<(R.S.F.)≤1.7 formula (1), wherein an R.S.F. means (D90−D10) / D50; D90 is a particle diameter (μm) corresponding to the cumulative 90% by volume of the cumulative particle diameter distribution from the small particle side; D50 is a particle diameter (μm) corresponding to the cumulative 50% by volume of the cumulative particle diameter distribution from the small particle side; and D10 is a particle diameter (μm) corresponding to the cumulative 10% by volume of the cumulative particle diameter distribution from the small particle side.

This invention provides a direct granulation method for preventing agglomeration of energetic, water-containing waste HTPB propellant, comprising: Step 1, microsphere suspension preparation: dissolving polylactic acid, polylactic acid-glycolic acid copolymer, and amphiphilic modified polymer mPEG-PLAA in a safe organic solvent, and preparing a microsphere suspension using a microfluidic emulsion method. The amphiphilic modified polymer mPEG-PLAA modifies the microspheres, forming a porous structure on the surface of the microspheres. Step 2, mixing and coating: directly mixing energetic, water-containing waste HTPB propellant with a water content of 55%–70% with the microsphere suspension obtained in Step 1, and using shear force or slight vibration to uniformly coat the energetic, water-containing waste HTPB propellant particles with a microsphere network, forming a microsphere coating layer. Step 3, granulation. The method of this invention is simplified and efficient: it does not require complete dehydration, operates directly in a water-containing state, shortens the granulation cycle to 2–12 hours, and reduces energy consumption per ton of propellant to 10–20 kWh.

The application provides a light-guiding gel and a production process thereof. The light-guiding gel is prepared from the following raw materials in percentage by mass: 0.3-0.4% of carbomer, 0.08-0.12% of polylactic acid-glycolic acid copolymer, 1.4-1.6% of shea butter, 4.5-5.5% of glycerol, 0.1-0.2% of preservative, 0.3-0.35% of triethanolamine, 1.6-2.2% of MIST BASE (HIGH), 0.008-0.012% of essence and the balance of purified water. The light-guiding gel prepared by the application has super light transmission and heat conduction properties and good biological safety. The application not only effectively improves the treatment effect, but also greatly relieves the burning sensation of the skin, avoids thermal damage, greatly reduces the discomfort, and is beneficial to the skin barrier repair.

The application discloses a lactic acid-glycolic acid copolymer with adjustable end carbon chain length and a preparation method and application thereof. 20 The lactic acid-glycolic acid copolymer with adjustable end carbon chain length is alcohol-terminated lactic acid-glycolic acid copolymer, and a structural formula is as shown in the following formula: wherein R is selected from C1-C The alcohol-terminated lactic acid-glycolic acid copolymer provided by the application can change the degradation speed of the polymer by controlling the carbon chain length of the end group, can be used as a carrier of a sustained-release drug delivery system of various drugs, can meet the requirement of different sustained-release time, and has a wide application range.

This invention discloses a method for preparing and applying a scaffold material carrying curcumin-metal ion chelate liposomes. The method involves chelating curcumin with metal ions to form liposomes, using these liposomes as the osteogenic-antibacterial active ingredient, mixing them with polymers polylactic-co-glycolic acid copolymer and polycaprolactone, and then preparing a novel antibacterial bone regeneration scaffold using electrospinning technology. The method of this invention is simple and easy to operate; the resulting scaffold exhibits good bone regeneration-promoting, anti-inflammatory, and antibacterial activities; this invention can prepare biodegradable composite scaffold materials with mechanical strength, biocompatibility, and drug-loading capacity, and can be applied in the field of bone tissue regeneration.

The invention relates to the technical field of pharmaceutical preparations, and particularly discloses curcumin-cyclodextrin-polylactic acid-glycolic acid copolymer composite nanoparticles as well as a preparation method and application thereof. According to the nanoparticles, curcumin is used as an active component, and cyclodextrin and a polylactic acid-glycolic acid copolymer are used as a carrier of a nano skeleton. The core of the preparation method is mainly as follows: firstly, curcumin and cyclodextrin form an inclusion compound in an organic solvent, then the inclusion compound is entrapped in a nanoparticle skeleton formed by a polylactic acid-glycolic acid copolymer, and finally, a nanoparticle colloidal solution is formed. The prepared composite nanoparticles are small in particle size, uniform in distribution, high in encapsulation efficiency and good in stability, the solubility, bioavailability and anti-tumor activity of curcumin can be remarkably improved, and the composite nanoparticles have wide application prospects in breast cancer treatment drugs.

The invention discloses a light-operated biological hybrid micro-robot drug-loaded delivery carrier and preparation and application thereof, and the light-operated biological hybrid micro-robot drug-loaded delivery carrier is composed of polymer nanoparticles carrying anti-fibrosis drugs and flexible living microorganisms, wherein 0.1-1 mg of the anti-fibrosis drug can be loaded on each flexible living microorganism with the order of magnitude of 1 * 10 < 5 >-1 * 10 < 6 >; the anti-fibrosis drug in the polymer nanoparticles loaded with the anti-fibrosis drug is nintedanib, the polymer is a polylactic acid-glycolic acid copolymer, and the mass ratio of the polylactic acid-glycolic acid copolymer to the nintedanib is (10: 1)-(20: 1). The ratio of lactide to glycolide in the polylactic acid-glycolic acid copolymer is 30: 70-50: 50, and the molecular weight of the polylactic acid-glycolic acid copolymer is 38000-54000. According to the photo-biological hybrid micro-robot, flexible living microalgae and a micro-robot drug delivery system are combined to achieve light-operated accurate regulation and control, light-operated permeation enhancement is achieved, drug retention time is prolonged, and good biocompatibility and safety are achieved.