126 results about "Polylactide co glycolide" patented technology

The invention relates to the field of sponge materials, and provides an antibacterial degradable sponge material and a preparation method thereof. The material is prepared from protocatechuic acid modified quaternized chitosan, quaternary ammonium salt grafted gelatin, sodium alginate, polyhydroxybutyrate, polycaprolactone, a polylactic acid-glycolic acid copolymer, hexamethylene diisocyanate, a foaming agent, nano cellulose, vitamin E, polyethylene glycol, triethylamine and dimethylformamide. Protocatechuic acid and quaternized chitosan are subjected to amidation modification, and chitosan and gelatin are subjected to quaternization treatment by adopting 2, 3-epoxypropyl trimethyl ammonium chloride, so that the antibacterial property and biodegradability of the material are improved. In the material preparation process, through vacuum degassing, foaming vacuum degree and humidity control and a multi-step drying process, it is ensured that the average pore size of the material is uniform (50-200 microns) and the porosity is high (50%-90%), and the obtained material has excellent antibacterial property and degradability and has wide application value.

The invention belongs to the technical field of veterinary preparations, and particularly relates to a tilmicosin premix and a preparation method thereof. The tilmicosin premix is prepared from the following raw materials: tilmicosin, a polylactic acid-glycolic acid copolymer, lecithin, modified hydroxypropyl methyl cellulose, grafted polyvinylpyrrolidone, polyethylene glycol and an antioxidant, a solid dispersion is formed through lecithin and grafted polyvinylpyrrolidone, the solubility and stability of tilmicosin are enhanced, polylactic acid-glycolic acid copolymer nano-microspheres are prepared through a double-emulsion solvent evaporation method, slow release of drugs is achieved, dodecyl modified hydroxypropyl methyl cellulose and polyethylene glycol are combined, and the sustained release effect is achieved. The solubility and the slow release characteristic are further enhanced. The activity of the granular premix is effectively preserved, and the granular premix is convenient to use and transport.

The invention discloses an anti-adhesion membrane loaded with nintedanib and a preparation method of the anti-adhesion membrane loaded with the nintedanib. The anti-adhesion membrane loaded with the nintedanib is prepared from a drug-loading substrate material and the nintedanib through electrostatic spinning, the material of the drug-loading substrate is one or more of polylactic acid, poly (p-dioxanone), a polylactic acid-glycolic acid copolymer, polycaprolactone and polyethylene glycol; a solvent adopted in the electrostatic spinning is hexafluoroisopropanol, and the voltage adopted in the electrostatic spinning is 10-14 kV. The nintedanib-loaded anti-adhesion membrane has the advantages that the tensile strength and the elongation at break are obviously improved, the mechanical property is obviously improved, the fiber distribution is uniform, the obvious anti-adhesion effect is realized, the nintedanib-loaded anti-adhesion membrane is suitable for common laparotomy, and the application prospect is wide.

The invention relates to an antibacterial fabric and a preparation process thereof, and relates to the technical field of fabrics. The antibacterial fabric comprises a fabric body, the fabric body is formed by weaving polyester fibers, an antibacterial fiber membrane layer is arranged on the fabric body, and a preparation method of the antibacterial fiber membrane layer comprises the following steps that honokiol is added into a hexafluoroisopropanol solution and stirred to be uniform, then a polylactic acid-glycolic acid copolymer is added and stirred to be uniform, and the antibacterial fiber membrane layer is obtained. Preparing an antibacterial fiber membrane layer through electrostatic spinning equipment; the antibacterial fabric has the effect of improving the antibacterial property of the fabric.

The invention relates to the technical field of biomedicine, and discloses a triclosan antibacterial coating surgical suture and a preparation method thereof.The suture comprises a base material and a surface antibacterial coating, the base material is selected from one of an absorbable single-strand material, an absorbable multi-strand material, a non-absorbable single-strand material and a non-absorbable multi-strand material, and the surface antibacterial coating is selected from one of an absorbable multi-strand material and a non-absorbable multi-strand material; the antibacterial coating comprises triclosan, a high-molecular carrier and an auxiliary agent, the surface energy of a hydrophobic material is improved, the porosity of a hydrophilic material is increased, the adhesive force between the coating and different base materials is ensured, the base materials can be covered, the uniformity deviation of the coating is avoided, and the coating is free of cracking or falling off through the combination of plasma cleaning and roughening treatment on the surface of the base materials. A synergistic system is formed by triclosan, nano-silver and titanium dioxide, a dual mechanism of targeted destruction of bacterial cell membranes and free radical oxidation is achieved, the antibacterial rate is increased, the MRSA inhibition rate is increased, the degradation rate is regulated and controlled through the polylactic acid-glycolic acid copolymer carrier molecular weight and the lactic acid / glycolic acid proportion, and a curing dynamic formula is combined.

The invention belongs to the technical field of biomedicine, and particularly relates to an alpha-cyperone bionic nano preparation as well as a preparation method and application thereof, the alpha-cyperone bionic nano preparation is prepared from a polylactic acid-glycolic acid copolymer, alpha-cyperone, a bionic membrane and follicle-stimulating hormone polypeptide, the biomimetic membrane is characterized in that alpha-cyperone is loaded on a polylactic acid-glycolic acid copolymer, the biomimetic membrane is biologically camouflaged on the outer layer, then the biomimetic membrane is modified by follicle-stimulating hormone polypeptide, and the amino acid sequence of the follicle-stimulating hormone polypeptide is as shown in SEQ ID NO.1. According to the alpha-cyperone bionic nano preparation disclosed by the invention, the alpha-cyperone is loaded by utilizing the polylactic acid-glycolic acid copolymer, so that the alpha-cyperone is easily dissolved in water, and the blood circulation half-life period is prolonged and the targeting capability of an ovary part is improved through biological camouflage of the bionic membrane; the modification of the follicle-stimulating hormone polypeptide further improves the targeting ability to granulosa cells, and liver and kidney toxicity and muscle injury are not found in the experiment process.

The invention relates to the technical field of medical gel, in particular to gynecological vaginal mucosa repairing gel and a preparation method thereof. Comprising the following raw materials: carbomer, glycerol, sodium hyaluronate, vitamin E, potassium sorbate, a modified nano polylactic acid-glycolic acid copolymer, modified nano collagen, albumin, tea tree essential oil, aloe, astragalus membranaceus, dandelion, stigma croci and ginseng. The modified nano polylactic acid-glycolic acid copolymer, the modified nano collagen and the albumin play a role through a synergistic effect, and the modified nano polylactic acid-glycolic acid is used as a skeleton structure for cell growth and is firmly attached to the active pharmaceutical ingredient-albumin compound; the polyacrylic acid chain on the surface controls the drug release rate by sensing the change of the pH value, the albumin initiates endocytosis through specific binding, and the albumin and the modified nano collagen jointly improve the anti-inflammatory performance, promote cell proliferation and differentiation and promote repair and regeneration of vaginal mucosa tissues.

The invention relates to the technical field of medicines, and discloses pedunculoside temperature-sensitive injectable hydrogel as well as a preparation method and application thereof. Specifically, the invention provides application of the temperature-sensitive injectable hydrogel with the pedunculoside in preparation of the medicine for treating the cardiovascular diseases, and the temperature-sensitive injectable hydrogel with the pedunculoside comprises the pedunculoside, a lactic acid-glycolic acid copolymer, polyvinyl alcohol and dipolylactic acid-glycolic acid copolymer polyethylene glycol. The microsphere-gel combined delivery preparation PE-M / Ge prepared by the preparation method disclosed by the invention is good in injectability and has a good temperature-sensitive gelling characteristic in vitro; the obvious gel property is realized, and the microspheres are uniformly distributed in the gel; the release of the drug can be effectively reduced, the release curve is closer to zero-order release, the dual controlled release system can more stably release the drug, the toxic and side effects caused by non-characteristic distribution of PE are reduced, and the bioavailability is improved. And the PE-M / Ge has no cytotoxicity to H9c2 cells and HUVECs cells, so that a foundation is laid for in-vivo pharmacodynamic experiments of rats.

The invention relates to the technical field of medical gel, and particularly discloses a sustained-release gel preparation for endometrial repair and a preparation method of the sustained-release gel preparation. Keratinocyte factor sustained-release microspheres containing keratinocyte factor-glucan particles and lactic acid-glycolic acid copolymer shells are constructed around keratinocyte factors, and the keratinocyte factor sustained-release microspheres are loaded by hyaluronic acid hydrogel containing polylysine, collagen and silk fibroin to form the sustained-release gel preparation for endometrial repair. The sustained-release gel preparation has the effect of promoting proliferation of human endometrial cells, can repair endometrial injury, promote injury healing and prevent uterine cavity adhesion, and has important significance in treating endometrial injury and improving physical and psychological health of women.

The present invention relates to a sustained release microsphere and a sustained release preparation comprising a GLP-1 receptor agonist or a pharmaceutically acceptable salt thereof. The present invention relates to a sustained release formulation, and more specifically, to a sustained release formulation comprising a GLP-1 receptor agonist or a pharmaceutically acceptable salt thereof, the sustained-release microparticles comprise a GLP-1 receptor agonist or a pharmaceutically acceptable salt thereof, one kind of low-viscosity polylactic acid-glycolic acid copolymer (PLGA) having an intrinsic viscosity of 0.14 dL / g to 0.24 dL / g, and two or more kinds of high-viscosity polylactic acid-glycolic acid copolymers having an intrinsic viscosity of 0.32 dL / g to 0.60 dL / g, so that the sustained-release microparticles do not have the problems of excessive release and delayed release in the initial stage of a drug. Long-term sustained release can be realized, and the bioavailability is excellent.

The invention discloses a lactic acid-glycolic acid copolymer with adjustable end group carbon chain length and a preparation method and application thereof. The lactic acid-glycolic acid copolymer with the adjustable end group carbon chain length is an alcohol-terminated lactic acid-glycolic acid copolymer, and the structural formula of the lactic acid-glycolic acid copolymer is as follows: # imgabs0 #, wherein R is selected from C1-C20 alkyl; m is 20 to 600, and n is 20 to 400. According to the alcohol-terminated lactic acid-glycolic acid copolymer, the degradation speed of the polymer is changed by controlling the length of a carbon chain of a terminal group, and the alcohol-terminated lactic acid-glycolic acid copolymer can be used as a carrier of a sustained and controlled release drug delivery system of various drugs, meets the requirements of different sustained release time and is wide in application range.

The invention discloses an anti-VEGF (vascular endothelial growth factor) intraocular sustained-release implant with high drug loading capacity and a preparation method thereof, and belongs to the technical field of medicines. The preparation method comprises the following steps: firstly, uniformly mixing crushed and sieved anti-VEGF active ingredients with a water-insoluble biodegradable sustained-release polymer to obtain premixed powder, setting the temperature of a hot-melt extruder and the rotating speed of a screw, mounting a mold, preheating, completely feeding the premixed powder, timing for 5-30 minutes, and starting extrusion to obtain the anti-VEGF intraocular sustained-release implant. Wherein the anti-VEGF medicine is prepared from ethanesulfonic acid nintedanib, nintedanib and voranib, and the water-insoluble biodegradable slow-release polymer is prepared from polylactic acid, a polylactic acid-glycolic acid copolymer and polycaprolactone. The in-vitro release characteristic of the prepared anti-VEGF intraocular sustained-release implant conforms to a zero-order release model, and the implant has an excellent sustained-release effect.

The invention discloses a donepezil and memantine compound sustained release preparation and a preparation process thereof, and belongs to the technical field of pharmaceutical preparations. The preparation consists of a donepezil hydrochloride quick-release layer and a memantine hydrochloride slow-release layer, wherein the quick-release layer comprises donepezil, starch, mannitol and the like, and realizes quick disintegration through granulation of a low-substituted hydroxypropyl cellulose aqueous solution; the slow-release layer comprises memantine, pinoresinol diglucoside, a polylactic acid-glycolic acid copolymer and chitosan, and the slow-release layer and the composite slow-release material have a synergistic effect through a low-temperature grinding technology, so that the degradation of the memantine is inhibited, and the sustained release of the memantine is controlled. The problem that an existing compound preparation is poor in stability is solved, and a safe and effective treatment choice which is taken once a day is provided for a patient suffering from the Alzheimer disease.

The invention provides application of polylactic acid and a copolymer thereof in preparation of a medicine for promoting tendon / ligament growth, and the molecular weight of the polylactic acid is 400-300000Da, preferably 5000-20000Da. The polylactic acid copolymer comprises one or more of a polylactic acid-glycolic acid copolymer, a polylactic acid-polyethylene glycol copolymer, a polyethylene glycol polylactic acid-glycolic acid copolymer, a polylactic acid-chitosan copolymer and a lactide-caprolactone copolymer, and preferably, the polylactic acid-glycolic acid copolymer. The effect of promoting ligament / tendon growth of polylactic acid and the copolymer thereof is found for the first time, and a new way is provided for treatment of ligament / tendon injuries.

The invention provides a composition for changing plasticity of bone meal particles as well as a preparation method and application of the composition, and relates to the technical field of biomedical materials. The composition is prepared from the following raw material components: bioactive glass, dihydrazide modified sodium hyaluronate, sodium hyaluronate with the molecular weight of 50kDa to 500kDa, a polylactic acid-glycolic acid copolymer and carboxymethyl cellulose. The preparation method of the dihydrazide modified sodium hyaluronate comprises the following steps: carrying out carboxyl activation on sodium hyaluronate, carrying out a cross-linking reaction on the activated hyaluronic acid and adipic dihydrazide, and then terminating the reaction. The composition provided by the invention not only can provide support, but also can adjust the degradation rate to be matched with the bone regeneration period, and all the components synergistically improve the mechanical property and the viscoelastic property. The composition disclosed by the invention can be formed in situ at a bone defect part, provides a space for growth and proliferation of bone cells, improves the biological activity and osteoinductivity of an artificial bone, and promotes bone growth and repair.

The present invention provides a bone defect repair material and a preparation method and use thereof, belonging to the field of bone repair materials. The bone defect repair material is prepared using polylactic acid-glycolic acid copolymer and calcium phosphate material as raw materials, wherein the mass ratio of polylactic acid-glycolic acid copolymer and calcium phosphate material is (5-7): (3-5). The bone defect repair material prepared by the present invention using high-temperature melting 3D printing technology has low-priced and easy-to-obtain raw materials, low-cost processing methods, simple and convenient processing methods, and easy to use in hospital scenarios, and the obtained bone defect repair material has high precision, which can ensure the precise design and manufacture of microporous structures.

The application discloses a water-soluble quantum dot nanometer material and a preparation method and application thereof, and the nanometer material comprises quantum dots and carboxyl-terminated poly(lactic-co-glycolic acid) coated on surfaces of the quantum dots. The carboxyl-terminated poly(lactic-co-glycolic acid) is used for encapsulating CsPbBr3 perovskite quantum dots, and a water-soluble perovskite nanocrystal material is prepared, which can retain high quantum yield (PLQY=88%) and water-oxygen resistance (>=30 days) and almost completely retains optical performance of the perovskite quantum dots.

The invention provides a long-acting microsphere sustained release preparation and a preparation method thereof, and belongs to the technical field of sustained release preparations, the long-acting microsphere sustained release preparation is prepared from the following raw materials of effective components: 9.5 to 10.5 parts of antipsychotic drug, 48 to 50 parts of hydroxypropyl-beta-cyclodextrin, 50 to 52 parts of polylactic acid-glycolic acid copolymer, 1.25 to 1.3 parts of glycerol triacetate and 10 to 11 parts of polyvinyl alcohol. The preparation method comprises the following steps: firstly, the hydroxypropyl-beta-cyclodextrin is used for clathration of the antipsychotic drug, the obtained clathrate compound is further clathrated by the polylactic acid-glycolic acid copolymer, and the long-acting microsphere sustained release preparation is obtained. According to the invention, the double-valve design of beta-CD and PLGA synergistic inclusion is utilized, so that the preparation can realize two-stage release; the macroscopic slow release characteristic of the PLGA is combined with the microcosmic express characteristic of the hydroxypropyl-beta-cyclodextrin, so that the technical limitation of a single carrier is broken through.

This invention belongs to the field of biomedical technology, specifically relating to a pharmaceutical composition formulation containing ertapenem and its preparation method. The ertapenem-containing pharmaceutical composition formulation comprises the following raw materials: 10-20 parts ertapenem, 40-60 parts choline-leucine ionic liquid, 30-50 parts polyethylene glycol-polylactic acid-glycolic acid copolymer, 2-5 parts gluconolactone, 2-3 parts antioxidant, 40-50 parts deionized water, 3-5 parts surfactant, and 20-30 parts mannitol. This invention utilizes choline-leucine ionic liquid to enhance the solubility and stability of the polyethylene glycol-polylactic acid-glycolic acid copolymer with ertapenem, forming uniform micelles to protect the drug from hydrolysis. Liquid nitrogen freezing technology is used to improve preparation efficiency and product quality, ensuring biocompatibility.

The invention discloses a hair-growing liniment and a preparation method thereof, and belongs to the technical field of pharmacy. The liniment comprises the following components in percentage by weight: 1-10% of minoxidil microspheres, 5-20% of a film-forming agent, 0.5-5% of a polypeptide compound, 5-30% of a liquid auxiliary material and the balance of deionized water. Wherein the minoxidil microspheres are of a three-layer structure composed of minoxidil in the inner layer, nano enzyme (cerium dioxide) in the middle layer and lactic acid-glycolic acid ester copolymer or chitosan in the outer layer, and controlled release and targeted delivery are achieved; the polypeptide compound is a compound of oldenlandia diffusa polypeptide and a copper curcumin derivative, and has the effect of synergistically repairing a hair follicle microenvironment. Tests prove that the liniment can remarkably prolong the release time of minoxidil, increase the retention volume of minoxidil in hair follicle parts and reduce absorption of the whole body, shows a hair growth promoting effect superior to that of a traditional preparation and a single-layer microsphere preparation in an animal model, and has good stability and use comfort.

The invention belongs to the technical field of medicine preparation, and particularly relates to an anti-HIV infection compound medicine microsphere composition, a medicine preparation and application. The invention firstly provides an anti-HIV (Human Immunodeficiency Virus) infection compound drug microsphere composition, which is composed of Cabotegravir, rilpivirine and at least one polylactic acid-glycolic acid copolymer, and comprises a first compound microsphere composition or a second compound microsphere composition, wherein one of the microsphere compositions is a co-coated microsphere formed by co-coating Cabotegravir and rilpivirine in the same microsphere; and the other microsphere composition is a mixture consisting of a microsphere for wrapping Cabotegravir and a microsphere for wrapping rilpivirine. The invention aims to provide a flexible preparation platform so as to optimize the long-acting treatment effect of the two anti-HIV drugs. For a composition form that one microsphere wraps two medicines, synchronous release and long-acting release of the two medicines are realized as much as possible; for another physically mixed composition form, independent regulation of release kinetics of a single drug is achieved as much as possible, so that the same administration cycle is achieved. The pharmaceutical preparation disclosed by the invention can be used for prevention before HIV exposure and long-term maintenance treatment of infected persons, and can be used for remarkably improving medication compliance and reducing the risk caused by virus drug resistance.

Provided are a bionic drug-loaded nanoparticle with expressed CXCR4, a method for preparing same, and use thereof. The method comprises: mixing a lactic acid-glycolic acid copolymer and an immunosuppressant in a certain ratio, and preparing the mixture into a drug-loaded nanoparticle using a microfluidic technology; preparing an MSC cell stably expressing membrane protein CXCR4 and lysing same to extract the cell membrane, so as to give an engineered stem cell membrane; and fusing the engineered stem cell membrane with the drug-loaded nanoparticle to give a bionic drug-loaded nanoparticle with expressed CXCR4. The bionic drug-loaded nanoparticle with expressed CXCR4 is a bionic cell membrane drug-loaded nanoparticle with chemotaxis functionality. By means of genetic engineering, the engineered stem cell membrane is modified to encapsulate a therapeutic agent, and directionally migrates to the lesions in the body and targets specific cells, thereby improving the drug distribution in vivo and reducing adverse effects of immunosuppressants.

The invention provides an anti-permeability and anti-sulfate corrosion additive for organic nano concrete, and belongs to the technical field of concrete. The additive disclosed by the invention contains ethylenediamine methylene sodium phosphate, sodium polyacrylate, sodium thiocyanate, polylactic acid-glycolic acid copolymer (PLGA), hydroxypropyl ethanolamine, a modified nano graphite material, chitosan quaternary ammonium salt, a silane coupling agent, nano volcanic ash powder and other components in a specific proportion. Wherein the modified nano-graphite material is prepared by modifying nano-graphite powder with polyether amine and a silane coupling agent; all the components are matched and the additive is prepared by adopting a special preparation method, and the additive has good impermeability and sulfate corrosion resistance when being used in concrete, and is stable and reliable.

The invention relates to the technical field of medical biological materials, and particularly discloses a composite electret flexible biological electrostatic electret patch and a preparation method thereof.The electrostatic electret patch comprises a backing layer, a medical pressure-sensitive adhesive layer and a functional layer which are sequentially arranged from outside to inside. According to the functional layer, at least one of polylactic acid, polyvinylidene fluoride and a polylactic acid-glycolic acid copolymer is selected as a polymer matrix to be compounded with graphene, a specific process combining ultrasonic dispersion and high-precision 3D printing is adopted, a deep-energy-level charge trap is introduced, the problems of high-conductivity filler agglomeration and surface charge leakage are solved, and the conductivity of the graphene is improved. The surface potential retention rate of the material can reach 60% or above after 900 days, the charge loss rate is not larger than 20% after 8-hour air exposure, and efficient physical electrostatic electret assisted sleep treatment under the drug-free and non-transdermal conditions is achieved.

A nanodiamond-reinforced nanofiber scaffold system for skin regeneration, consisting of a multilayered, electrospun nanofiber matrix formed from one or more biocompatible polymers selected from polycaprolactone (PCL), poly(lactic-co-glycolic acid) (PLGA), chitosan, gelatin or collagen, wherein nanodiamonds are present in an amount of 0.1 to 5 wt.-% are incorporated and surface-functionalized with oxygen, hydroxyl, or carboxyl groups to ensure homogeneous dispersion within the polymer matrix, the scaffold being characterized by a controlled fiber diameter in the range of 100 to 800 nm, an interconnected porosity between 60 and 90%, a tensile strength of 2 to 10 MPa, a degradation time of 2 to 8 weeks, and the ability to improve cell adhesion, proliferation, and migration of fibroblasts and keratinocytes, while simultaneously exhibiting antioxidant activity, reduced formation of reactive oxygen species, and the optional incorporation of bioactive agents selected from growth factors, antioxidants, or antimicrobial compounds to accelerate wound healing and skin tissue regeneration.

The present invention relates to the technical field of heterocyclic compound drugs and their preparation and application, and specifically to a tropane alkaloid composition for the treatment of COPD and its application. The composition combines tropane alkaloids, mannose-6-phosphate and polylactic acid-glycolic acid copolymer, and is constructed into a nanocomposite by nanoparticle preparation technology for aerosol inhalation administration. The composition aims to solve the problems of low bioavailability and lack of targeting in conventional administration of tropane alkaloids. Targeted delivery is achieved by introducing mannose-6-phosphate into the surface of nanoparticles, promoting drug enrichment in the lungs, and using polylactic acid-glycolic acid copolymer to control drug release, thereby increasing local drug concentration and therapeutic efficacy in the lungs.

The invention relates to the technical field of modified calcium carbonate, in particular to modified calcium carbonate, which comprises the following structures: an inner core: lithium battery recycled calcium carbonate slag, which comprises 1.2-1.8 wt% of Li2CO3 and 0.5-1.2 wt% of MgCO3; the middle layer is a polydopamine (PDA) coating film, the thickness of the polydopamine (PDA) coating film is 50-80 nm, and the polydopamine (PDA) coating film is used for providing active amino (-NH2); the shell is a fluorine-containing silane and polylactic acid-glycolic acid copolymer (PLGA) composite layer, the grafting rate is larger than or equal to 90%, and the molar ratio of lactic acid to glycolic acid of PLGA is 75: 25. Quantized data of performance improvement and dispersibility are as follows: the oil absorption value is 18 ml / 100 g (compared with 28-32 ml / 100 g in the prior art), and the bulk density is 0.25 g / cm < 3 > (loose agglomeration). Functions are as follows: flame retardance: the oxygen index (LOI) reaches 34.5% (no flame retardance exists in the prior art); the antibacterial property is that the Escherichia coli inhibition rate is 99.2% (ASTM E2149 standard), and the environmental protection property is that 2.8 tons of limestone can be reduced for each ton of products, and 1.2 tons of CO2 emission can be reduced.

The invention belongs to the technical field of biomedical materials and targeted drug delivery systems, and discloses a targeted controlled-release drug delivery system based on a polymer nano-carrier and a preparation method thereof.The system is of a three-layer structure and comprises a core layer formed by taking polyvinyl alcohol as a matrix and used for efficiently entrapping a drug, and an outer layer formed by taking polyvinyl alcohol as a matrix and used for efficiently entrapping the drug; the shell layer formed by the polylactic acid-glycolic acid copolymer is used for providing structural stability and slow release capability, and the shell layer formed by the polyvinyl alcohol-hydroformylated glucan grafted copolymer is used for realizing microenvironment response release. And the surface of the shell layer is covalently modified with a tumor membrane targeting aptamer and a microenvironment response peptide, so that accurate recognition and local trigger release can be realized. The system has good particle size stability, responsive release ability and tumor cell targeted enrichment effect, and is suitable for efficient delivery and controlled release of various antitumor drugs.

This invention discloses a method for preparing a 3D-printed hydrogel scaffold for cartilage repair, comprising: providing methacrylamide chitosan; providing 2-([1,1-biphenyl]-4-ylcarbamoyl)benzoic acid@polylactic acid-glycolic acid copolymer microspheres; obtaining a 3D-printed bio-ink for cartilage repair using methacrylamide chitosan, 2-([1,1-biphenyl]-4-ylcarbamoyl)benzoic acid@polylactic acid-glycolic acid copolymer microspheres, recombinant collagen CF-1552, and lithium magnesium silicate as main raw materials; and obtaining a 3D-printed bio-ink for cartilage repair using the 3D-printed bio-ink for cartilage repair as a raw material to obtain a 3D-printed hydrogel scaffold for cartilage repair. This 3D-printed hydrogel scaffold has advantages such as antibacterial properties and the ability to promote the differentiation of human bone marrow mesenchymal stem cells (hBMSCs) into chondrocytes, and can be used for cartilage repair, potentially bringing new curative opportunities for cartilage injury diseases.

This invention discloses a biodegradable, highly bioactive magnesium bone particle, its preparation method, and its applications, belonging to the field of biomedical materials technology. Using magnesium bone particles as a matrix, an active composite coating layer comprising biodegradable polymer components and inorganic phase components is formed on its surface to construct biodegradable, highly bioactive magnesium bone particles. The biodegradable polymer components are one or more selected from polycaprolactone, polylactic acid, polylactic-co-glycolic acid copolymer, polyhydroxyalkanoates, chitosan, and their derivatives; the inorganic phase is one or more selected from hydroxyapatite, titanium dioxide, calcium phosphate materials, and combinations thereof. The preparation method includes magnesium bone particle matrix preparation, active composite layer slurry preparation, magnesium bone particle coating, and post-treatment. The prepared biodegradable, highly bioactive magnesium bone particles exhibit good degradation regulation performance and excellent bioactivity, and can be used in bone tissue engineering, bone defect repair, and scaffold filling fields.