3results about How to "No hemolytic" patented technology

This invention discloses a strain of *Lactobacillus johnsonii* DA0207 and its applications, belonging to the field of microbial technology. The *Lactobacillus johnsonii* DA0207 provided by this invention was isolated from the enteric coating of *Deinagkistrodon acutus*, and can grow well on MRS agar medium. It is non-hemolytic, sensitive to a variety of common antibiotics, and has good safety. This strain has good acid and bile salt tolerance, can adapt to the intestinal environment of humans and animals, and has growth inhibitory effects on a variety of common pathogenic bacteria. Fermentation of *Periplaneta americana* powder with this strain significantly increased the content of various amino acids and peptide active compounds in the fermentation supernatant. The supernatant showed growth inhibition and apoptosis-promoting effects on colon cancer cells. The supernatant also showed significant anti-inflammatory effects on DSS-induced colitis in mice, significantly reducing the levels of inflammatory factors. This provides a new avenue for the further development and utilization of functional foods, biological agents, and *Periplaneta americana*.

This invention relates to the field of food antibacterial and preservative technology, specifically to a plant lactobacillus 9, a compound preservative containing plant lactobacillus 9, and their applications. The plant lactobacillus 9 is produced from *Lactobacillus plantarum* with the preservation number CCTCC NO: M 2026808. Lactobacillus plantarum The amino acid sequence of this plant lactobacillus 9 is N-Thr-Asp-Gly-Ala-Ala-Phe-OH. This plant lactobacillus 9 exhibits strong antibacterial activity against Listeria monocytogenes, Bacillus subtilis, Micrococcus luteus, methicillin-resistant Staphylococcus aureus, Escherichia coli, Pseudomonas fluorescens, Salmonella typhimurium, and Pseudomonas aeruginosa, and demonstrates outstanding stability. It is a safe and reliable biological preservative. Its effectiveness is significantly enhanced when combined with chitosan, making it a potential alternative to chemical preservatives for controlling foodborne pathogens in the agricultural and food industries and extending the shelf life of meat and meat products.

The present application relates to a strain of Bacteroides fragilis and its application, the strain is preserved in China General Microbiological Culture Collection Center (CGMCC) on April 14, 2026, and the preservation number is: CGMCC No. 38257.The strain can regulate STING-dependent training immunity, effectively resist Salmonella typhimurium and H9N2 avian influenza virus infection, maintain the integrity of the intestinal barrier of the host, and reduce inflammatory damage.The Bacteroides fragilis of the present application has good biological safety, and the strain can be used as a training immunity inducer, and the strain is expected to be a candidate probiotic or vaccine adjuvant for preventing / treating bacterial and viral infections, suitable for human health and poultry farming, and provides a new solution to resist antibiotic resistance.