A stable torasemide injection and its preparation method

Abstract

There is provided an injection with torasemide as the main active ingredient in the invention, the preparing method of the injection is also included in the invention. The stability of the injection in the invention has been greatly improved. There is solubilizing agent and stabilizer in the preparation, the pH value is 9.0 or larger. The preparing method includes the following steps: adding 1-50% (by weight) of solubilizing agent to certain amount of injecting water; adding torasemide to the water, after it is completely dissolved, adding 0.1-5% part of stabilizer; adding water to requested amount and stirring uniformly; adding activated char to adsorb for 30min at high temperature; decarbonizing and filtering; adding medically used alkali to regulate the ph value to 9.0 or larger; aseptically filtering; after the assay is approved, packaging, degerming and stocking. The advantages of the invention include: high stability, short preparing time, low cost, no haemolyticus, blood vessel stimulus and allerfic response, low growing speed of relative substances.

Description

technical field

[0001] The torasemide injection of the present invention is used for medicine, and the main route of administration is intravenous injection. The injection of the present invention has good stability. Torsemide, the chemical name is: 1-isopropyl-3-[(4-m-tolylamino-3-pyridyl)sulfonyl]urea, clinically used for diuresis and Na excretion + and row Cl - data of. technical background

[0002] Torasemide is a pyridine sulfonylurea mixed diuretic, its chemical name is: 1-isopropyl-3-[(4-m-tolylamino-3-pyridyl)sulfonyl]urea, The structural formula is as follows:

[0003]

[0004] Molecular formula: C 16 h 20 N 4 o 3 S

[0005] Molecular weight: 348.42

[0006] Loop diuretics are widely used to treat various types of edema, and the common adverse reaction is hypokalemia. Torasemide not only has a strong diuretic effect but also has less potassium loss, which is related to its competitive inhibition of aldosterone.

[0007] Torsemide can be used for the t...

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