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Parecoxib Sodium is a water-soluble, injectable sodium salt form of parecoxib, an amide prodrug of the cyclooxygenase II (COX-2) selective, non-steroidal anti-inflammatory drug (NSAID) valdecoxib, with anti-inflammatory, analgesic, and antipyretic activities.Upon intravenous or intramuscular administration, parecoxib is hydrolyzed by hepatic carboxyesterases to its active form, valdecoxib.
Lyophilized etoricoxib powder for injection and suspension thereof
PCT designated stageWO2026108687A1Organic active ingredientsPowder deliveryCholic acidParecoxib sodium
Provided in the present invention is a lyophilized Etoricoxib powder for injection. The lyophilized powder comprises: (A) 10-70% of Etoricoxib; (B) 0.1-10% of a wetting agent; and (C) 30-90% of a lyoprotectant, wherein the wetting agent is selected from at least one of oleic acid, oleate, cholic acid, or cholate. Further provided in the present invention are a method for preparing the lyophilized powder, a suspension containing the lyophilized powder, and use thereof. The lyophilized Etoricoxib powder for injection of the present invention has an appropriate particle size, maintains a stable particle size after reconstitution, and features good long-term storage stability. The prepared suspension can be quickly released to reach an effective therapeutic level after intravenous injection, has a long duration of action, and exhibits a better effect compared with parecoxib sodium, an analgesic injection commonly used in current clinical practice.
Owner:SICHUAN KELUN PHARMA RES INST CO LTD +1