Parecoxib sodium pharmaceutical composition for injection
What is Al technical title?
Al technical title is built by PatSnap Al team. It summarizes the technical point description of the patent document.
A technology of parecoxib sodium and parecoxib, which is applied in the direction of drug combinations, active ingredients of heterocyclic compounds, antipyretics, etc., can solve problems such as inconvenience in the production process, achieve stable quality, simple and easy method, and reduce The effect of market risk
Inactive Publication Date: 2012-06-27
TIANJIN SONGRUI MEDICAL TECH
View PDF2 Cites 13 Cited by
Summary
Abstract
Description
Claims
Application Information
AI Technical Summary
This helps you quickly interpret patents by identifying the three key elements:
Problems solved by technology
Method used
Benefits of technology
Problems solved by technology
Phosphate buffer solution (pH=7.8~8.0) was used, and the pH stability of the drug was improved, and the storage stability period can reach 36 months. During the development process, it was accidentally found in a wider pH range ( pH7.5~8.5), the pharmaceutical composition of parecoxib sodium for injection with phosphate buffer, mannitol and sodium hydroxide as auxiliary materials has better stability than that of foreign commercially availabl
Method used
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more
Image
Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
Click on the blue label to locate the original text in one second.
Reading with bidirectional positioning of images and text.
Smart Image
Examples
Experimental program
Comparison scheme
Effect test
Embodiment 1
[0081] The formula of every 1000 described parecoxib sodium pharmaceutical compositions consists of:
[0082] Parecoxib sodium as parecoxib 40g
[0083] Dipotassium hydrogen phosphate 11.18g
[0084] Potassium dihydrogen phosphate 0.82g
[0085] Mannitol 20g
[0086] Appropriate amount of sodium hydroxide
[0087] Add water for injection to 2ml.
[0088] The preparation process includes:
[0089] 1) Weigh dipotassium hydrogen phosphate and potassium dihydrogen phosphate, add appropriate amount of water for injection to dissolve until completely, and set aside;
[0090] 2) Take 90% of the phosphate buffer solution in 1), and the temperature is 40±5°C, add the prescribed amount of parecoxib sodium, and stir until it is completely dissolved by visual inspection;
[0091] 3) Add 0.1% medical activated carbon to the solution in 2) and stir for 15 minutes to decolorize. After decolorization, filter and remove the carbon, add an appropriate amount of water ...
Embodiment 2
[0099] The formula of every 1000 described parecoxib sodium pharmaceutical compositions consists of:
[0100] Parecoxib sodium as parecoxib 20g
[0101] Dipotassium hydrogen phosphate 11.18g
[0102] Potassium dihydrogen phosphate 0.82g
[0103] Mannitol 40g
[0104] Appropriate amount of sodium hydroxide
[0105] Add water for injection to 2ml.
[0106]Preparation process: with embodiment 1.
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more
PUM
Login to view more
Abstract
The invention relates to a stable parecoxib sodium pharmaceutical composition for injection. The pharmaceutical composition specifically comprises parecoxib sodium and additive for injection, wherein the additive at least contains a phosphatic buffer with a pH of 7.8-8.0, and other additive is selected from mannitol and sodium hydroxide. The parecoxib sodium pharmaceutical composition for injection provided by the invention is filled in a colorless neutral borosilicate glass tube injection bottle, has good stability, stable pH and little stimulation on skin, and is convenient for transportation and storage. The parecoxib sodium pharmaceutical composition for injection provides reasonable preparation prescription and preparation technology for clinical medicament usage and is easy for realization of industrialization.
Description
technical field [0001] The invention relates to medicines in the field of medicine, in particular to a stable pharmaceutical composition of parecoxib sodium for injection. Background technique [0002] Inflammatory reactions after noxious stimuli such as surgery and trauma can lead to the release of inflammatory mediators and pain-causing substances. In addition to directly causing pain, they can also cause blood vessels to dilate, tissue edema, increase the sensitivity of effector receptors, and reduce the pain threshold. This results in peripheral hyperalgesia. Selective COX-2 inhibitors can effectively inhibit the expression of peripheral COX-2 and reduce the synthesis of peripheral prostaglandins, thereby exerting analgesic and anti-inflammatory effects; at the same time, they can inhibit the expression of central COX-2, inhibit the synthesis of central prostaglandins and inhibit pain hypersensitivity, Give full play to the dual advantages of peripheral and central anal...
Claims
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more
Application Information
Patent Timeline
Application Date:The date an application was filed.
Publication Date:The date a patent or application was officially published.
First Publication Date:The earliest publication date of a patent with the same application number.
Issue Date:Publication date of the patent grant document.
PCT Entry Date:The Entry date of PCT National Phase.
Estimated Expiry Date:The statutory expiry date of a patent right according to the Patent Law, and it is the longest term of protection that the patent right can achieve without the termination of the patent right due to other reasons(Term extension factor has been taken into account ).
Invalid Date:Actual expiry date is based on effective date or publication date of legal transaction data of invalid patent.
Login to view more 
Login to view more