37results about How to "Has anti-inflammatory effects" patented technology

The invention relates to the field of biological three-dimensional printed meniscus bracket, in particular to a biological three-dimensional printing preparation method of a chondrocyte loading anti-inflammatory meniscus bracket. The biological three-dimensional printing preparation method of the chondrocyte loading anti-inflammatory meniscus bracket can well simulate a three-dimensional macroscopic morphology, interior microcosmic collagen fibers and a porous structure of meniscus tissues, is beneficial to cell growth and exchange of nutrients and promotes regeneration of the meniscus tissues. For the biological three-dimensional printing preparation method of the chondrocyte loading anti-inflammatory meniscus bracket, by selecting polycaprolactone to print a frame structure of the meniscus bracket, enough mechanics is provided to joint support; meanwhile, by loading chondrocytes, operation of cell culture in vitro after bracket printing is avoided; and by loading a fullerene material, the bracket has the anti-inflammatory effect.

The invention discloses a preservative-free skincare mask essence. The formula of the mask essence contains no preservatives or other sensitizing substances, so the mask essence reduces the irritation of a mask to skins, and is suitable for sensitive skins. All ingredients in the formula do not degenerate or change the physical state after existing at 115 DEG C for 15-30 min; the addition of zinchyaluronate makes the mask essence have anti-inflammatory and moisturizing effects; and the molecular weights of the sodium hyaluronate have three types which are a large type, a medium type and a small type, and a ratio among the three types of molecular weights is controlled to achieve a best moisturizing effect.

The invention relates to the field of meniscus stents prepared by carrying out biological three-dimensional printing, and specifically discloses a biological three-dimensional printing preparation method of an anti-inflammatory meniscus stent loaded with cartilage cells. The biological three-dimensional printing preparation method of the anti-inflammatory meniscus stent loaded with the cartilage cells is capable of very well imitating three-dimensional macromorphology, internal micro-collagen fiber and porous structure of meniscus tissue, thereby facilitating cell growth and nutrient exchangeso as to promote regeneration of the meniscus tissue. The frame structure of the meniscus stent is printed by adopting selected polycaprolactone; and thus, sufficient mechanical support for the jointis provided. In addition, being loaded with the cartilage cells, the anti-inflammatory meniscus stent is capable of avoiding cell culture operation in vitro after printing; and moreover, the stent isloaded with a fullerene material, so that the stent has anti-inflammatory effects.

The invention relates to a lip care product with high content of shea butter and a preparation method of the lip care product. The lip care product comprises the following ingredients by mass percentage: 50-60% of first shea butter, 19-24% of second shea butter, 7-20% of third shea butter, 0.1-3% of a shea butter unsaponifiable matter, 0.001-0.5% of shea extract and the balance of auxiliary materials, wherein the sliding melting point of first shea butter is 51 DEG C; the sliding melting point of second shea butter is 16 DEG C; the sliding melting point of third shea butter is 12 DEG C; the sliding melting point of a shea butter unsaponifiable matter is 10 DEG C. The lip care product provided by the invention contains 80% or more of shea butter, so that the lip care product is mild, has no stimulation and good breathability and can be fast absorbed by skin. Therefore, the lip care product has the effects of deep moisturizing and high-efficiency moisturizing and can effectively repair various problems of wounds, sun cracks, peeling, whitening, sensitivity and the like caused by sunburns and cold injuries of the skin; meanwhile, the lip care product can protect the lip skin from being attacked by stern climate and ultraviolet, so as to achieve an effect of lip care in summer.

The invention discloses a compound capable of resisting blue ray injury. The compound is prepared from the following traditional Chinese medicine active components through compounding: bamboo leaves,golden cypress, flos sophorae, grape seeds, rhizoma polygoni cuspidate, liquorice and herba centellae. The invention further provides a preparation method of the compound. The preparation method comprises the following steps: weighting the traditional Chinese medicine raw material components, and carrying out process stages of extraction, filtration, settling, centrifugation, micro-filtration membrane processing and concentration, so as to obtain an extract; dissolving the extract into liquid with a mass fraction of 0.1%-10%, so as to obtain the compound. The compound has strong absorptivity and anti-oxidation and restoration efficacies in a waveband range of 400nm-480nm in a blue light region. The compound provided by the invention has remarkable effects and is combined with a traditionalChinese medicine technique, so that the compound is high in safety and can be applied to cosmetics.

The invention discloses an infant mild bathing effervescent tablet containing an amino acid cleaning component, and a preparation method thereof. The effervescent tablet comprises, by weight ratio, 25-45 parts of anhydrous citric acid, 25-50 parts of sodium bicarbonate powder, 15-35 parts of anhydrous sodium sulfate, 0.5-5 parts of sodium cocoyl glycinate, 0.05-2 parts of dipotassium glycyrrhizinate, 0.05-5 parts of betaine and 0.05-2 parts of essential oil, and the essential oil is one or more of essential oils of lavender, chamomile, wormwood and white pomelo leaves. The sodium bicarbonate powder and an amino acid surfactant sodium cocoyl glycinate are used as cleaning components, the instant natural plant essential oil which is natural, safe and mild is also used, and all the componentsare compacted by a mold to form molds with various characteristics. The effervescent tablet is portable, and can instantly produce fine bubbles and release slight aromatic smell of the essential oilwhen placed in a bath basin or a bathtub during use in order to help users to relieve nerves, eliminate fatigue, resist allergy and keep moist.

The invention relates to a tableted ampelopsis grossedentata leaf candy and a preparation method thereof. The tableted candy comprises the following components in parts by weight: 10-20 parts of ampelopsis grossedentata leaf extract, 5-10 parts of eucommia leaf extract, 5-10 parts of fragrant solomonseal rhizome extract, 1-5 parts of kudzuvine root powder, 50-100 parts of carbohydrates or sugar alcohols, and 20-40 parts of an adhesive. The invention also relates to a preparation method of the tableted ampelopsis grossedentata leaf candy. According to the obtained tableted ampelopsis grossedentata leaf candy, the natural activity of the preparation raw materials is comprehensively utilized, and the candy has an anti-inflammation effect, and is convenient to carry, eat and preserve.

The invention provides a traditional Chinese medicine composition for treating and / or preventing oral diseases. The traditional Chinese medicine composition is prepared from pseudo-ginseng powder, radix salviae milliorrhizae extract and wild chrysanthemum extract. The invention further provides toothpaste capable of treating and / or preventing gingivitis. The toothpaste contains the traditional Chinese medicine composition and auxiliary materials. The ointment is moderate in thickness, rich and fine in foam and high in solubility; due to the fact that natural plant extract is added, the toothpaste is mild, high in safety performance, remarkable in effect and capable of reducing the number of oral cavity germs and regulating the environment of the oil environment.

The invention discloses radix pseudostellariae active hexacarbaldehyde oligosaccharide as well as a preparation method and application of the radix pseudostellariae active hexacarbaldehyde oligosaccharide. The structure of the radix pseudostellariae active hexacarbaldehyde oligosaccharide is shown as a formula I, the molecular weight of the radix pseudostellariae active hexacarbaldehyde oligosaccharide is 1476.6185 Da, and monosaccharide of the radix pseudostellariae active hexacarbaldehyde oligosaccharide comprises mannose, glucose and galactose (the molar ratio of the mannose to the glucoseto the galactose is 0.076: 0.814: 2.600). The invention also provides the preparation method of the radix pseudostellariae active hexacarbaldehyde oligosaccharide, and the method comprises the following steps: carrying out alcohol extraction, water extraction, alcohol precipitation, enzyme-Sevage method deproteinization and DEAE-52 anion exchange column separation and purification, and collectingthe product with the molecular weight of 1000-2000Da to obtain the radix pseudostellariae active hexacarbaldehyde oligosaccharide. The oligosaccharide obtained in the invention has anti-inflammatory and antioxidant activity and relatively strong reducing capacity, and can have remarkable antagonism on inflammatory bowel diseases by regulating and controlling the variety and abundance of intestinalflora.

The invention discloses a pharmaceutical composition. The pharmaceutical composition comprises tofacitinib, a pharmaceutically acceptable salt of tofacitinib and a penetration enhancer. The invention further discloses a pharmaceutical preparation prepared from the composition and application thereof. According to the invention, the selected pharmaceutically acceptable salt of tofacitinib has better solubility, the preparation processing difficulty is simplified, and the permeability of the preparation in the skin is increased; compared with free tofacitinib, the tofacitinib is more stable, and the safety and good efficacy of the medicine are ensured. According to the invention, diethylene glycol monoethyl ether is selected as a solvent and an absorption enhancer, so that no irritation is caused; the preparation disclosed by the invention has an anti-inflammatory effect in a dinitrofluorobenzene-induced delayed hypersensitivity reaction model, can also reduce the area of white spots of leucoderma patients and treat atopic dermatitis, and can be used for treating and preventing autoimmune diseases such as leucoderma, alopecia areata, scleroderma, psoriasis, atopic dermatitis and the like.

The invention provides an anti-dandruff composition, and a preparation method and application thereof. The anti-dandruff composition is prepared from cajeput essential oil, juniperus formosana essential oil, caraway essential oil and a radix et rhizoma rhei palmatae extract. The invention also provides the preparation method of the anti-dandruff composition. The preparation method comprises the following steps: dispersing the rheum palmatum extract in a solvent to obtain a dispersion liquid; mixing the cajeput essential oil, the juniperus formosana essential oil and the caraway seed essential oil to obtain a mixed solution; and adding the mixed solution into the dispersion solution, and stirring to obtain the anti-dandruff composition. The anti-dandruff composition disclosed by the invention has excellent effects of inhibiting growth of pathogenic bacteria and maintaining balance of scalp flora, and can generate anti-inflammatory and itching-relieving effects in cooperation with the effect of inhibiting histamine secretion; all the functional components are natural plant extracts, so that the irritation to a human body is relatively small; and the preparation method is simple and efficient and has wide application value.

The invention provides a black-bone chicken peptide composition which is prepared from the following ingredients in parts by weight: 10 to 30 parts of black-bone chicken egg white peptide and 10 to 300 parts of black-bone chicken oligopeptide. The prepared black-bone chicken peptide composition prepared by the invention has effects of easing pain, resisting inflammation and preventing and treatingprimary dysmenorrhea. The invention further provides application of the black-bone chicken peptide composition in preparing health care food, food and medicine for preventing and treating dysmenorrhea and gynecological inflammation. The black-bone chicken peptide composition can serve an effective ingredient of health care food, food and medicine for improving, preventing and treating primary dysmenorrhea and / or treating gynecological inflammation.

The invention provides a whitening, anti-inflammatory and moisturizing mask and a preparation method thereof, and relates to the technical field of cosmetics. The invention relates to a whitening, anti-inflammatory and moisturizing mask, which comprises the following raw materials: 0.7%-1.2% of pearl powder, 0.1%-0.3% of carbomer, 0.05%-0.6% of tranexamic acid, 0.05%-0.3% of a surfactant, 0.05%-0.1% of tremella polysaccharide, 0.05%-0.1% of a chondrus crispus extract, 1.3%-3.6% of a centella asiatica extract, 0.3%-0.8% of a scutellaria baicalensis root extract, 0.03%-0.1% of a pogostemon cablin leaf extract, 1%-2.1% of a humectant, 0.5%-1.8% of a skin conditioner, 0.3%-0.8% of EDTA disodium and the balance of water. The whitening, anti-inflammatory and moisturizing mask has the advantages of being capable of continuously resisting inflammation on the face and maintaining skin stability and good in moisturizing effect.

The invention relates to a medicine composition for treating acute pulpitis and application thereof, and belongs to the field of study and development of oral medicines. The medicine composition for treating the acute pulpitis and the application aim at overcoming the technical defects of poorer effect of the pulpitis treating medicine and stronger drug resistance of pathogenic bacterium to conventional antibiotics in the prior art. The medicine composition has the advantages that by using morinidazole, calculus bovis factitius and matrine as main active components, the obvious synergistic treatment effect on bacteria resisting, inflammation diminishing and pain relieving is realized, and the medicine composition is suitable for being popularized and applied to the clinical application ofpulpitis medicines.

The invention relates to an animal semen diluting powder and application thereof, and belongs to the technical field of animal reproduction. The animal semen diluting powder is dissolved in a PBS buffer solution to prepare a pig semen diluting solution; the semen diluting solution comprises 0.1-0.3 g / L of liquiritin, 1-3 g of sodium glutamate, 0.5-1.0 g of L-arginine, 0.1-0.3 g of N-acetylcysteine, 1-3 g of fructose, 10-15 g of glucose, 2-4 g of potassium citrate, 0.5-1 g of potassium chloride, 1-2 g of EDTA, 1-2 g of sodium carbonate and 0.1-0.3 g of origanum oil. The liquiritin can also be replaced with glycyrrhetinic acid. The animal semen diluting powder does not adopt any antibiotics, and various components have a synergistic effect, so that the time and the motility rate of preservedsperms can be obviously improved, the integrity rate of acrosomes can be improved, and the pregnancy rate of artificial insemination after dilution can be increased.

The invention discloses anti-inflammatory and bactericidal amino acid hydrogel as well as a preparation method and application thereof. The preparation method comprises the following steps: providing an amino acid solution and a sodium alginate solution in percentage by weight; and mixing the amino acid solution and the sodium alginate solution, reacting under an acidic atmosphere condition, and soaking and cleaning with deionized water to remove residual hydrogen ions after the reaction is finished, so as to obtain the anti-inflammatory and bactericidal amino acid hydrogel. According to the anti-inflammatory and bactericidal amino acid hydrogel prepared by the preparation method disclosed by the invention, amino acid substances with antibacterial and anti-inflammatory functions are selected as raw materials, and the prepared hydrogel body has an anti-inflammatory effect under the condition of not doping any anti-inflammatory drugs, so that the probability of using antibiotic drugs is reduced, the reaction conditions are mild and simple, and the preparation method is suitable for industrial production. The preparation method has the advantages that the preparation method is simple, the preparation method is suitable for large-scale production, a physical method is adopted, toxicity is small, safety is achieved, different drugs can be doped on the premise that different use purposes need to be enhanced, the antibacterial and anti-inflammatory effects cannot be affected, and potential application prospects are achieved in the aspects of biological clinical medical patches and dressings.

The invention discloses a novel antibacterial peptide resisting infection of airborne bacteria and intracellular bacteria and an application of the antibacterial peptide. The novel antibacterial peptide TAT-KR-12 is formed by joining a biological active fragment KR-12 of anthropogenic antibacterial peptide LL-37 and a cell penetrating peptide TAT. The novel synthesized antibacterial peptide TAT-KR-12 has a function of resisting airborne bacteria and has the effect of resisting intracellular bacteria while having good biocompatibility. Besides, the antibacterial peptide has an anti-inflammatoryeffect. The antibacterial peptide is prepared with a simple preparation process, is high in efficiency and good in repeatability, has a good effect on the intracellular bacteria while effectively resisting the airborne bacteria, has certain anti-inflammatory property, makes up the defect of conventional antibacterial drugs and has great clinical significance.

The invention is applicable to the technical field of daily chemical products, and provides an amino acid moisturizing mask and a preparation method thereof, wherein, the amino acid moisturizing maskcomprises the following raw materials in percentage by weight: 10 to 30 percent of polydecene; 2 to 6 percent of natural betaine, 4 to 8 percent of coconut oil acyl propyl betaine, 1 to 5 percent of octanoic acid triglyceride, Stearyl alcohol polyether-2 5-1.5%; Stearyl alcohol polyether-21 0.2 to 0.8 percent; 0.2 to 0.8 percent of emulsify wax, 0.2 to 0.8 percent of thickener, 0.2 to 0.8 percentof triethanolamine, 0.01 to 0.02 percent of preservative. The rest is water. The amino acid moisturizing mask has good moisturizing effect, can improve the deep cell center of the skin deeply throughthe absorption of effective ingredients of the mask on the skin surface, continuously moisturizes the skin, has anti-inflammatory effect, is gentle and non-irritating, and is suitable for any skin.

The invention belongs to the field of biological medicine, and relates to a preparation method and application of a cichorium glandulosum Boiss lignin extract, in particular to the preparation methodand application of the cichorium glandulosum Boiss lignin extract. The cichorium glandulosum Boiss lignin extract C20H24O6 can be taken as an inflammation lead compound, the compound has an inhibitioneffect on NO, TNF-alpha and PGE2 which are generated from RAW264.7 cells activated by LPS, is low in cytotoxicity and can significantly reduce expression of COX-2 protein; the compound can also improve the increase phenomenon, caused by the LPS, of the mouse spleen index and thymus index and reduce the concentration of IL-1beta, caused by the LPS, in serum of a mouse. According to the technical scheme, the novel application of the lignin compound C20H24O6 and the preparation method of the compound are provided, and according to the novel application and preparation method of the compound, theapplication range of the compound can be enlarged. According to the technical scheme, the compound can be applied to the fields of medicine preparation and the like.

The present invention relates to a composition containing an extract of Camellia sinensis, preferably an extract of a novel variety of Camellia sinensis (Jangwon number 3), and more particularly, to acomposition containing, as an active ingredient, an extract of Camellia sinensis having a high content of epigallocatechin-3-O-(3-O-methyl) gallate (EGCG3'Me; 3'-O-Me-EGCG). A composition according to the present invention containing, as an active ingredient, an extract of Camellia sinensis having a high content of epigallocatechin-3-O-(3-O-methyl) gallate has an antioxidant effect due to the elimination and suppression of free radicals, has an anti-aging effect on the skin due to having an excellent ability to inhibit the formation of collagenase, has an anti-inflammatory effect due to inhibiting the expression and secretion of inflammatory factors, such as prostaglandin and IL-8 and the like, in skin cells, and has an excellent anticancer effect with respect to cancer cell lines derivedfrom various tissues.

The invention discloses an extraction method of orange peel cell water and orange peel essential oil, which mainly utilizes a low-temperature-vacuum (reduced pressure) extraction technology, firstly, orange peel is primarily extracted for a short time, primary extraction liquid and orange peel residues are obtained through separation; then a certain amount of cellulase and pectinase are added into the primary extraction liquid, and are inversely poured into the orange peel residues after the primary extraction; then low-temperature-reduced-pressure extraction is carried out again for a certain time, and an extracting solution is collected for standing treatment for layering to obtain the orange peel cell water which is green, natural, rich in active ingredients and sweet, fragrant and soft in smell and the orange peel essential oil which is rich in fragrance. The extraction method disclosed by the invention is high in extraction rate, and the extracted orange peel cell water and orange peel essential oil are excellent in quality and high in volatile component content.

The invention discloses a freckle removing cream which is prepared from the following raw materials in percentage by weight: 56 to 57 percent of water, 5.2 to 5.6 percent of propylene glycol, 14 to 15 percent of glycerol, 0.1 to 1.5 percent of borneol, 0.20 to 0.24 percent of butylated hydroxytoluene, 1.6 to 2.0 percent of chloramphenicol, 0.2 to 0.3 percent of ketoconazole, 0.2 to 0.3 percent of tioconazole, 0.2 to 0.3 percent of procaine penicillin, 0.9 to 1.3 percent of lauryl sodium sulfate, 0.3 to 0.5 percent of fatty alcohol polyvinyl chloride ether, 8 to 9 percent of ceteayl alcohol, 3.2 to 3.6 percent of palmitic acid, 2.8 to 3.2 percent of stearic acid, 1.5 to 2.5 percent of emulsifier, 0.3 to 0.5 percent of ammonium triacetate and 0.1 to 0.3 percent of carbomer. The freckle-removing cream is simple to prepare, contains traditional Chinese medicine components, can remove freckles, improve the skin color and repair bean marks and facial couperose skin, and is a skin-care freckle-removing cream.

The invention discloses an active six-carbon aldehyde oligosaccharide of Radix Pseudostellariae and its preparation method and application. The structure of the active six-carbon oligosaccharide of Radix Pseudostellariae is shown in formula I, the molecular weight is 1476.6185Da, and its monosaccharide composition is: mannose, glucose and galactose (molar ratio is 0.076:0.814:2.600). The present invention also provides a preparation method of the oligosaccharides, through alcohol extraction, water extraction, alcohol precipitation, enzyme-Sevage method for protein removal, and DEAE-52 anion exchange column separation and purification methods to collect products with a molecular weight between 1000Da and 2000Da , to obtain the active six-carbon aldehyde oligosaccharide of Radix Pseudostellariae. The oligosaccharide obtained in the present invention has anti-inflammation, anti-oxidation activity, and strong reducing ability, and can significantly antagonize inflammatory bowel disease by regulating the type and abundance of intestinal flora.

The invention provides a rice amino acid moisturizing facial mask. The rice amino acid moisturizing facial mask comprises the following raw materials in percentage of weight: polydecene 10-30%; natural betaine 2-6%; cocoamidopropyl betaine 4-8%; caprylic triglyceride 1-5%; ceteareth-12 0.2-0.8%; glyceryl stearate 0.2-0.8%; sodium acryloyldimethyl taurate 0.2-0.8%; triethanolamine 0.2-0.8%; preservative 0.01-0.02%; rice amino acid stock solution 0.1-2%; and balance of water. The prepared rice amino acid moisturizing facial mask has good moisturizing effect, can further improve cell centers in deep skin through absorption of active ingredients in the facial mask by outer skin surface, continuously moisturizes skin, and has anti-inflammatory effect. The rice amino acid moisturizing facial mask is mild, non-irritating, and applicable for any skin.

The invention discloses a chlorhexidine gluconate antibacterial transparent dressing, and relates to the technical field of medical appliances. The chlorhexidine gluconate antibacterial transparent dressing comprises a printing layer, a flexible layer, a adhesive layer, a dressing layer and a protective layer. The surface of the printing layer is adhered to the back of the flexible layer, the adhesive layer is arranged on the surface of the flexible layer, the dressing layer is located in the middle of the surface of the flexible layer, and the back of the protective layer is adhered to the surface of the flexible layer through the adhesive layer. The chlorhexidine gluconate antibacterial transparent dressing has an excellent killing effect on vegetative forms of bacteria on the surface ofthe skin and some viruses and fungi by adding the chlorhexidine gluconate and silver nanoparticles, with little irritation; the dressing has analgesic and anti-inflammatory effects by adding honeysuckle flower extract, paeonol and urocystin; the dressing layer is yellow and transparent, so that the wound site can be clearly observed; and the transparent dressing is good in adhesion to the skin, so that the transparent dressing is convenient to use.

The invention discloses a compound for resisting blue light damage. The active ingredient of the compound is prepared by compounding traditional Chinese medicine bamboo leaves, cork cork, Sophora japonica, grape seed, Polygonum cuspidatum, licorice and Centella asiatica. The present invention also provides a preparation method of the above-mentioned anti-blue light damage compound. The raw material components of traditional Chinese medicine are weighed, and the extract is obtained through extraction, filtration, sedimentation, centrifugation, microfiltration membrane treatment, and concentration process stages; the extract is dissolved The liquid with a mass fraction of 0.1-10% is the anti-blue light damage compound. The anti-blue light damage compound has strong absorption in the range of 400-480nm in the blue light region, and has the functions of anti-oxidation and repair. The anti-blue light compound provided by the invention has remarkable effects, is combined with traditional Chinese medicine technology, has high safety, and can be used in cosmetics.

The invention provides a traditional Chinese medicine composition for treating and / or preventing oral diseases. The traditional Chinese medicine composition is prepared from pseudo-ginseng powder, radix salviae milliorrhizae extract and wild chrysanthemum extract. The invention further provides toothpaste capable of treating and / or preventing gingivitis. The toothpaste contains the traditional Chinese medicine composition and auxiliary materials. The ointment is moderate in thickness, rich and fine in foam and high in solubility; due to the fact that natural plant extract is added, the toothpaste is mild, high in safety performance, remarkable in effect and capable of reducing the number of oral cavity germs and regulating the environment of the oil environment.

The invention discloses a lignan compound and a separation method and application thereof, and sesquilignan compounds I and II are obtained mainly through multistage separation steps of ethyl acetate extraction, reduced pressure distillation, organic solvent gradient elution, liquid chromatography separation and the like. Pharmacological activity experiments show that the compound provided by the invention has obvious anti-inflammatory activity, which shows that the compound has a good application prospect in preparation of drugs for preventing or treating inflammation.