Antibacterial peptide TAT-KR-12 resisting infection of airborne bacteria and intracellular bacteria as well as preparation method and application of antibacterial peptide
A technology of planktonic bacteria and antimicrobial peptides, applied in the field of bioengineering, can solve the problems of ineffective resistance to intracellular bacteria and achieve good results, simple process and low cost
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[0032] The present invention will be further described below in conjunction with the accompanying drawings and the following specific embodiments. It should be understood that the following embodiments and / or accompanying drawings are only used to illustrate the present invention rather than limit the present invention.
[0033] 1. Preparation of peptides:
[0034]Peptides were prepared by standard Fmoc-based solid-phase synthesis techniques on Rink amide MBHA resin. Dicyclohexylcarbodiimide (DCC) and 1-hydroxybenzotriazole (HOBt) were used as coupling reagents, and a 10-fold excess of Fmoc amino acids was added in each coupling cycle. At room temperature with TFA / H2O / thioanisole / phenol / ethanedithiol / triisopropylsilane (81.5:5:5:5:2.5:1, v / v / v / v / v / v After cleavage and deprotection of the mixture of / v) for 2 hours, the crude peptide was repeatedly extracted with diethyl ether and placed on an analytical Vydac C18 column (length: 250mm, inner diameter: 20mm, pore diameter: P...
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