45 results about "Thioanisole" patented technology

A nonaqueous electrolyte secondary battery includes a positive electrode having a positive electrode active material, a negative electrode containing a negative electrode active material capable of being doped / undoped with lithium, and a nonaqueous electrolyte. The nonaqueous electrolyte contains at least one of thiols, thiophenes, thioanisoles, thiazoles, thioacetates, aromatic sulfones, and the derivatives thereof. The capacity of the battery is not significantly degraded after cycling and its cycle life is significantly long.

The invention discloses a method for continuously preparing a 2-aryl-benzothiophene / furan compound by utilizing an electrochemical micro-channel reaction device. The preparation method comprises the following steps: dissolving ethynyl thioanisole / phenylethynyl anisole and an iodine-containing electrolyte in water and acetonitrile to prepare a homogeneous solution, then introducing the prepared homogeneous solution into a feeding hole of an electrochemical micro-channel reaction device by utilizing an injection pump in single-strand sample introduction, and reacting under the action of a direct-current power supply to obtain the product 2-aryl-benzothiophene / furan compound; wherein the electrochemical micro-channel reaction device comprises an anode electrode, a cathode electrode, an electrolytic tank bracket, a reaction tank, the direct-current power supply and a temperature control module; wherein the reaction tank is positioned between the anode electrode and the cathode electrode, and a closed serpentine flow path is formed between the anode electrode and the cathode electrode; the anode electrode and the cathode electrode are arranged on the electrolytic tank bracket; one endsof the anode electrode and the cathode electrode are connected with each other and are connected with the direct-current power supply; and the temperature control module is embedded in the electrolytic tank bracket and is used for controlling the temperature of liquid in the reaction tank.

The invention discloses a Baeyer-Villiger monooxygenase and an application of the Baeyer Villiger monooxygenase, and belongs to the technical field of bioengineering. The invention provides another Baeyer-Villiger monooxygenase aiming at the problems of reported Baeyer-Villiger monooxygenase, such as low catalytic activity to substrate thioether, poor thermal stability, low ee value of a product and the like. The enzyme shows high stereoselectivity to linear ketone, cyclic ketone and thioether substrates, has high catalytic activity to cyclohexanone and thioanisole, and can be used for preparing high-purity products. Therefore, the problems of the existing monooxygenase can be directly and effectively solved. When diphenyl sulfide is used as a substrate to prepare S-benzosulfoxide, the conversion rate can reach 95% or above, and the yield can reach 99.5%. According to the present invention, a new thought and a new method are provided for industrial production of the optically active sulfoxide.

The present invention relates to a method for solid-phase synthesis of atosiban, comprising the following steps: 1) taking Rink Amide resin as a carrier, and obtaining H2N-Rink Amide resin after removing Fmoc-protection; 2) using HOBT and DIPCI as condensation reagents, and The carboxyl group of Fmoc-Gly-OH is connected with the amino group of the resin to obtain Fmoc-Gly (resin); 3) adopt the Fmoc strategy to synthesize the remaining amino acids in the solid phase sequence sequentially; 4) carry out solid phase cyclization with iodine; 5) then use the cleavage reagent ( Trifluoroacetic acid / thioanisole / 1,2-ethanedithiol / water) cleavage and ether precipitation to obtain crude atosiban peptide; 6) the crude product was prepared and separated by HPLC to obtain pure atosiban.

The invention relates to a method for synthesizing a selenized benzothiophene compound. According to the method, in an organic solvent, under the condition of oxygen, arylboronic acid and selenium powder generate a benzene selenium-based free radical in situ under the action of a silver catalyst, and the benzene selenium-based free radical and alkynyl thioanisole are further subjected to a free radical tandem cyclization reaction to obtain the selenized benzothiophene compound. The present invention further discloses a selenized benzothiophene compound prepared by the method. According to the present invention, the method has characteristics of easily available alkynyl thioanisole as the raw material, inexpensive and easily available elemental selenium, wide reaction substrate range, good functional group tolerance, simple reaction condition and high yield and high purity of product, develops the new synthesis rote and method for selenized benzothiophene compounds, and further has good application potential and research value.

The invention belongs to the field of organic synthesis. The invention provides a method for preparing 4-methylsulfonylphenylacetic acid. The synthetic method is to use thioanisole as a starting material to obtain 4-methylthiobenzaldehyde through Vilsmeier reaction, and after Darzen reaction, 4-methylthiobenzaldehyde is hydrolyzed and decarboxylated to obtain 4-methylthiobenzaldehyde aldehyde. 4‑Methylthiophenylacetaldehyde is oxidized to give 4‑Methylsulfonylphenylacetic acid.

The invention provides a synthesis method of 2-(4-cyano) pyridyl (3-cyano) thioanisole. The invention also provides a synthesis method of 4-(2-formamido) pyridyl (3-bromo) thioanisole. According to the technical scheme, 2-chloro-4-cyanopyridine / 4-chloropyridine-2-formamide, micromolecular sulfur compounds and 3-chloro / bromobenzyl alcohol are used for directly synthesizing 2-(4-cyano) pyridyl (3-cyano) thioanisole (I) and 4-(2-formamido) pyridyl (3-bromo) thioanisole (II) under the condition of no additional catalysts. The method has the advantages that the reaction conditions are simple; inert gas protection is not needed; solvents are not needed; the operation is easy. By the method, the 20-time amplification production can be conveniently realized; the product gram grade preparation is performed, so that certain study and industrial application prospects are realized.

The invention relates to the technical field of medicines and particularly relates to a method for preparing firocoxib. Raw materials used in the preparation method are conventional reagents in the market, thioanisole which is easily volatized and has strong odor, isobutyryl chloride with high corrosion and liquid bromine with high toxicity, easy volatilization and strong corrosion are abandoned.The method is suitable for industrial production.

The invention discloses a heterogeneous photosensitizer based on a metal organic framework material as a carrier as well as a preparation method and application of the heterogeneous photosensitizer, and belongs to the technical field of preparation of environment-friendly functional composite materials. The heterogeneous photosensitizer disclosed by the invention is a metalloporphyrin@ZIF-8 composite material, wherein a metalloporphyrin compound which has strong absorption in a visible light region and can efficiently generate singlet oxygen (1O2) is loaded into a ZIF-8 metal organic framework material pore channel through a simple "one-pot" self-assembly method. Finally, the prepared heterogeneous photosensitizer is used for catalytic oxidation of thioanisole, then the catalyst can be recycled through simple centrifugation, washing and drying, and the heterogeneous photosensitizer is circularly used for catalytic oxidation of thioanisole and degradation of bisphenol A. The preparation method is simple, easy to operate, environmentally friendly, low in cost, good in repeatability and short in consumed time; the heterogeneous photosensitizer has strong absorption in a visible region, and 1O2 can be efficiently generated, so that thioether compounds can be selectively oxidized into sulfoxide under the condition of stirring at room temperature, the conversion rate is high, and the reusability is good.

The invention relates to the technical field of essences, and relates to a lasting fragrance type essence, which comprises the following components by mass: 5-10 parts of linalyl acetate; 3-5 parts ofbenzyl acetate; 10 to 15 parts of geranyl acetate; 10 to 13 parts of vanillate acetate; 8 to 12 parts of ethyl acetoacetate; 15 to 20 parts of methyl dihydrojasmonate; 13 to 18 parts of galaxolide; 3-6 parts of lemon oil; 10 to 15 parts of linalool; 12 to 18 parts of geraniol; 6 to 10 parts of vanillyl alcohol; 5 to 10 parts of ionone; 6 to 10 parts of alpha-hexylcinnamaldehyde; 10 to 13 parts ofdipropylene glycol; 1 to 2 parts of thioanisole; 3-5 parts of glycerol; and 0.5-1 part of coumarin. The invention has the effect of prolonging the fragrance retention time of the essence.

The invention discloses a method for pyrolysis of thymosin beta-4. The method comprises the step of carrying out pyrolysis on thymosin beta-4 peptide resin to obtain crude peptide, wherein a mixed solvent of trifluoroacetic acid, thioanisole, dithioglycol, phenol, water, dimethyl sulfide and ammonium iodide is used as a pyrolysis reagent in the pyrolysis process. According to the method for pyrolysis of thymosin beta-4, the purity of crude peptide is greatly improved, meanwhile the total yield is greatly increased, the production cost is reduced, and the method is simple in process and convenient for industrial production.

The invention discloses a synthetic method of an etoricoxib intermediate 4-methylsulfonyl acetophenone, wherein the comprises the following steps: step 1, adding anhydrous aluminum trichloride and acetyl chloride in a dichloromethane system to obtain a reaction solution; step 2, dropwise adding the reaction solution into thioanisole into the reaction solution; step 3, standing for liquid separation, extracting a water phase by using dichloromethane, combining organic phases, and washing the combined organic phases by using a 10% sodium bicarbonate aqueous solution; step 4, evaporating the washed organic phase to dryness, adding n-heptane, crystallizing, washing, and drying to obtain acetylphenylmethyl sulfide; and step 5, adding the acetylphenylmethyl sulfide obtained in the step 4 into an acetone system, and further reacting to obtain 4-methylsulfonyl acetophenone; or adding the acetylphenylmethyl sulfide obtained in the step 4 into an acetic acid system, and stirring for dissolving to obtain a reaction mixture; and further reacting to obtain the 4-methylsulfonyl acetophenone. The energy consumption is reduced, the reaction is more stable, and the benefit is high.

The invention discloses a synthesis technology of thymosin alpha1, which comprises the following steps: synthesizing multiple segments according to the difficult-synthesis sequence of thymosin alpha1, wherein a solid-phase segment condensation method is adopted for the area of difficult sequences so as to improve the synthesis quality and shorten the synthesis time, and a conventional step-by-step condensation method is adopted for the area of easy-synthesis sequences; obtaining all-protected thymosin alpha1 peptide resin on Wang Resin; cracking the peptide resin to obtain crude peptide by taking TFA / m-cresol or TFA / thioanisole / EDT / anisole as a cracking reagent; dissolving the crude peptide and filtering; and performing preparative reversed phase HPLC purification, desalting, rotary evaporation and freeze drying to obtain a finished product of thymosin alpha1 of which the purity can exceed 99%. According to the technology disclosed by the invention, the purity of the synthesized crude peptide can reach about 80%, the purification is easy, and the total yield can reach 30%. The total yield and product quality of thymosin alpha1 produced by the method disclosed by the invention are both much remarkably improved than those of other methods reported in documents; and moreover, the production cycle can be shortened by 40-50%, the production cost is reduced, and the method is suitable for large-scale preparation of high-purity thymosin alpha1.

The invention discloses a method for synthesizing 2-(2-chlorophenyl)-4-(4-fluorophenyl)-5-[4-(mesyl) phenyl] thiazole. The method includes: thioanisole is reacted with acetyl chloride to generate 4-methylthio acetophenone which is reacted with 4-methyl fluorobenzoate to generate 1-(4-fluorophenyl)-3-(4-methylthio benzene)-1,3 diketone which is reacted with tert-butyl nitrite to generate 1-(4-fluorophenyl)-2-(4-methylthio benzene)-1,2 diketone which is reacted with 2-chlorobenzaldehyde to generate 2-(2-chlorophenyl)-4-(4-fluorophenyl)-5-[4-(methylthio) phenyl]thiazole which is oxidized to generate 2-(2-chlorophenyl)-4-(4-fluorophenyl)-5-[4-(mesyl) phenyl] thiazole. The method avoids usage of nitrine reagent and has important application value.

The invention relates to a chiral catalytic synthesis method of thiamphenicol which is a chloramphenicol broad-spectrum antibiotic. Thioanisole serves as an initating raw material, acylation and bromo are achieved, nitrogen iridine containing substituent groups is synthetized, and a qualified product which meets the requirement of drug administration is synthetized through chiral catalytic reduction, oxidizing reaction, acidification loop opening, deprotection and acylation reaction. The chiral catalytic reduction includes that under the action of a catalyst trans-RuC12[(R)-xylbinap][(S)-DPEN], [1-substituent group nitrogen iridine-2-group] [4-(methylthio group) phenyl group] ketone is subjected to hydrogenation reduction to obtain [1-substituent group nitrogen iridine-2-group] [4-(methylthio group) phenyl group] ketone with a high ee value and a high de value. D-methylsulfonylphenyl serine ethyl ester used in industrial production serves as a raw material to synthetize the thiamphenicol, the D-methylsulfonylphenyl serine ethyl ester is obtained through chemical chiral resolution by using a racemic compound, and the other half of the raw material is wasted. According to the unsymmetrical chiral catalytic dynamic reduction method, waste of the other half of the raw material is avoided, the utilization rate of a material is improved, and the production cost is reduced.