124results about "Quinone preparation by oxidation" patented technology

The invention relates to the field of preparation of 2-alkyl anthracene, and discloses a method for optimizing a 2-alkyl anthracene oxidation process based on a feeding mode, which comprises the following steps: adding a solution containing 2-alkyl anthracene and a catalyst into an oxidation reactor through feeding, and reacting in an oxygen-deficient environment to obtain a mixture containing 2-alkyl anthraquinone, and the feeding mode is continuous feeding. The concentration of 2-alkyl anthracene in the oxidation reactor can be controlled through the feeding rate by selecting a continuous feeding mode; the concentration of the 2-alkylanthracene in the oxidation reactor of the continuous feeding process is low, so that the conversion rate of the 2-alkylanthracene and the selectivity of the 2-alkylanthraquinone are remarkably improved, the content of tail oxygen is controlled within a safe range, and the economic benefit and the safety performance are increased.

The present invention relates to a process of oxidation of 2,3,6-trimethyl phenol by oxygen or an oxygen-containing gas in the presence of in the presence of a copper (II) halide as catalyst and of water and a specific diol comprising at least on tertiary hydroxyl group as reaction medium.

The present disclosure relates to the synthesis of Vitamin K2 bearing varying prenyl side chains. The synthesis comprises the reaction of phenyl sulfone of tert-butyl dimethyl silyl (TBDMS) protected mono prenyl menadiol with prenyl halides bearing varying prenyl units in the presence of the phase transfer catalyst followed by reductive desulphonation to yield TBDMS ether of Vitamin K2. The TBDMS ether is then oxidized in the presence of chromium trioxide and periodic acid to yield the corresponding Vitamin K2.

This invention provides a rapid synthesis method for p-benzoquinone derivatives, comprising: using a phenol derivative as a raw material as shown in formula (2) as a raw material, and oxidizing it with a high-valent iodine reagent to obtain the p-benzoquinone derivative shown in formula (1) in one step. The conditions for the one-step synthesis include: a reaction temperature equal to or below 10°C. This invention also provides a p-benzoquinone derivative synthesized by the above method. Compared with the prior art, this invention uses simple phenolic compounds as substrates and trivalent iodine as an oxidant, and can rapidly and efficiently obtain quinone compounds in one step, which shortens the reaction steps and avoids the use of dangerous reagents tert-butyl peroxide and titanium tetrachloride.

The invention relates to the technical field of organic synthesis, and discloses a preparation method of trimethylbenzoquinone, which comprises the following steps: mixing a reaction solution containing unsym-trimethylbenzene and an organic solvent with a catalyst, and adding an oxidizing agent to carry out oxidation reaction to obtain trimethylbenzoquinone, wherein the catalyst comprises a pyridine compound and methylrhenium trioxide. According to the method, the unsym-trimethylbenzene is adopted as a raw material, the methylrhenium trioxide and the pyridine compound are adopted as catalysts, the trimethylbenzoquinone is prepared through oxidation of the oxidizing agent, the product yield is high, and the consumption of the oxidizing agent is low.

The present disclosure relates to a combination of redox active compounds for use as redox flow battery electrolytes. Further provided herein is a kit comprising the combination, a redox flow battery, and a method using the combination, kit and / or redox flow battery of the present disclosure.

The invention discloses a method for synthesizing biphenol in a water phase, belongs to the technical field of fine chemical engineering, and aims to solve the explosion safety risk caused by the use of an organic solvent in the conventional alkylphenol oxidative coupling process. According to the method, a phase transfer catalysis system composed of boric acid, Tween-80, dodecylphenol polyoxyethylene ether and copper chloride is adopted, water serves as a solvent, oxygen or air is introduced at the temperature of 60-90 DEG C, alkyl phenol is subjected to an oxidative coupling reaction to generate alkyl biquinone, and then biphenol is prepared through hydrogenation reduction. The method thoroughly avoids the use of an organic solvent, eliminates the hidden danger of explosion from the source, and has the advantages of high intrinsic safety, environmental friendliness and low cost.

[Abstract] [Problem] To provide a method for producing a dealkoxyphenylation product with high yield from a substrate, e.g., a sugar, which is bonded to an alkoxyphenyl group through an oxygen atom. [Solution] A substrate that is bonded to a phenyl group substituted by a C1 to C5 alkoxy group at a para- or ortho-position through an oxygen atom is reacted with a λ3-iodane in a fluorous alcohol and water, whereby a dealkoxyphenylation product can be obtained with high yield under mild conditions.

The invention belongs to the technical field of synthesis of fine chemical intermediates, and particularly relates to a continuous flow synthesis method and device of 2-methylbenzoquinone. The method comprises the following steps: a) dissolving 2-methylphenol and a Schiff base cobalt catalyst in an organic solvent to prepare a raw material solution; b) conveying the raw material liquid to a microreactor by using a pump, mixing the raw material liquid with oxygen or air in the conveying process, and then carrying out continuous oxidation reaction under certain reaction conditions to generate 2-methylbenzoquinone; and c) separating and purifying the reaction product to obtain the 2-methylbenzoquinone product.The micro-channel reactor is adopted to strengthen mass transfer and reduce the safety risk, the Schiff base cobalt is used as the catalyst, air or oxygen is used as the oxidizing agent, the reaction efficiency and yield are improved, pollution is reduced, and efficient, green and safe production is achieved.

Disclosed herein are embodiments of compounds that exhibit Crk-like protein inhibition. The compound embodiments can be used to suppress or prevent tumor cell growth, augmenting immune cell response in a subject having, or suspected of having, a chronic viral infection or a cancer, and / or to inhibit a Crk-mediated signaling pathway. Methods of making and using the compound embodiments are disclosed herein.

The present invention relates to the photooxidation of 2,3,6-trimethylphenol using light in the long wavelength region of the visible spectrum with methylene blue as a photosensitizer in a solvent mixture of water and alcohol to give 2,3,5-trimethylbenzoquinone.

The invention belongs to the technical field of catalyst preparation and organic synthesis, and discloses a copper-magnesium-aluminum hydrotalcite catalyst for synthesizing tetra-tert-butylbiphenyl diquinone through oxidative coupling of 2, 6-di-tert-butylphenol and a preparation method of the copper-magnesium-aluminum hydrotalcite catalyst, and the preparation method comprises the following steps: (1) dissolving soluble salts of Cu, Mg and Al in water to obtain a mixed salt solution A; (2) dissolving NaOH and / or Na2CO3 in water to obtain an alkali solution B; (3) dissolving a gemini surfactant in a mixed solvent composed of water and lower alcohol to obtain a solution C; (4) under continuous stirring and protective gas atmosphere, dropwise adding the solution A and the solution B into the solution C to form mixed slurry; and (5) carrying out ultrasonic-assisted aging treatment on the mixed slurry at 60-80 DEG C for 6-16 hours, carrying out centrifugal separation, washing the solid until the filtrate is neutral, and drying and grinding the solid to obtain the catalyst. The catalyst has more active sites, and is high in catalytic activity, good in selectivity and easy to separate and recover.

The present invention provides a method for preparing 1,4-naphthoquinone compounds by selective oxidation of aromatic ketones, which is a new method for catalytic oxidation of aromatic ketones to prepare 1,4-naphthoquinone compounds using copper-based and vanadium-based heterogeneous catalytic materials, belonging to the technical field of fine chemicals. This method uses molecular oxygen as the oxidant, and a heterogeneous copper-based and vanadium-based catalytic material to prepare 1,4-naphthoquinone compounds by liquid-phase selective oxidation of aromatic ketones under mild conditions. The Cu-N-C and V-N-C composite materials used therein are obtained by mixing inorganic metal salts with organic nitrogen-containing compounds to obtain a precursor, and calcining in an inert atmosphere at a temperature of 300-800 °C for 0.5-10 h. The method provided by the present invention uses aromatic ketones as raw materials and molecular oxygen as the oxidant, and the catalytic reaction conditions are mild with few pollutants. It is a new route for preparing 1,4-naphthoquinone compounds, with strong practicability and broad application prospects.

The present invention discloses a tungsten-oxygen complex, a preparation method, and its application in olefin oxidative cracking and C-H bond oxidation, belonging to the technical field of metal coordination compound functional materials. The present invention utilizes bipyridine ligands and metallic tungsten to synthesize a novel tungsten-oxygen complex under H2O2 conditions. The complex has air-stable properties and can be used as a high-efficiency catalyst for olefin oxidative cracking and C-H bond oxidation to prepare carbonyl compounds. Compared with the prior art, the present invention has the following characteristics: (1) The catalyst provided by the present invention is a novel tungsten catalyst with a novel structure and is prepared for the first time; (2) The catalytic reaction is carried out under a homogeneous catalytic system and can be used not only for olefin oxidative cracking, but also for C-H bond oxidation to synthesize aldehydes and ketones; (3) The catalytic reaction uses oxygen or air as a green oxidant; (4) Abundant chemical raw materials (styrene derivatives, phenylethane derivatives) are used for the green synthesis of carbonyl compounds.

The invention relates to the technical field of organic compounds, and discloses a production and preparation method of chloranil. The method comprises the following steps: dissolving parachlorophenol in a mixed solvent composed of water and glacial acetic acid, adding a specific catalyst and polyvinylpyrrolidone, heating, introducing chlorine for reaction, monitoring the reaction endpoint through TLC, filtering the reaction liquid while the reaction liquid is hot to recover the catalyst, cooling and crystallizing the filtrate, washing, and drying in vacuum to obtain the golden yellow chloranil. Wherein the catalyst is prepared by taking acidified attapulgite as a carrier, modifying the carrier with a silane coupling agent and then loading multi-element metal active components of iron, copper and cerium, and has high activity and stability. According to the method, a continuous chlorination process close to a'one-pot method 'can be realized, the reaction efficiency and the product crystallinity are remarkably improved, byproducts are effectively prevented from being generated, the used raw materials are low in price, the obtained chloranil is high in purity and stable in color, meanwhile, the catalyst can be recycled, and the production cost and the environmental pollution risk are reduced.

The invention relates to the technical field of organic synthesis, in particular to a synthetic method of 2, 5-dibromobenzoquinone, which takes hydroquinone as an initial raw material and comprises the following two steps: step 1, adding 0.5-2% (based on the mass of hydroquinone) of a phase transfer catalyst (such as tetrabutylammonium bromide) into a glacial acetic acid solvent, reacting with bromine at 10-15 DEG C to generate 2, 5-dibromohydroquinone, and reacting for 2-4 hours at the temperature of 10-15 DEG C to obtain 2, 5-dibromohydroquinone; after the reaction, stably storing an intermediate under the protection of inert gas; 2, oxidizing the 2, 5-dibromohydroquinone into 2, 5-dibromobenzoquinone at the temperature of 45-50 DEG C by taking acetonitrile as a solvent and adopting a tert-butyl hydroperoxide (TBHP)-sodium nitrite composite oxidant (the molar ratio is (10: 1)-(15: 1)); meanwhile, glacial acetic acid and acetonitrile mother liquor generated in the reaction process are subjected to vacuum rectification recovery (the acetonitrile recovery rate is greater than or equal to 90%, and the glacial acetic acid recovery rate is greater than or equal to 88%) for recycling. The invention solves the problems of more brominated byproducts, low oxidation efficiency, solvent waste and unstable intermediate in the prior art.

Disclosed herein are compositions (e.g., pharmaceutical compositions, nutraceutical compositions) and methods useful for, inter alia, modulating levels of certain chorismate metabolites in a subject (e.g., in the gut of a subject). Modulation of levels of certain chorismate metabolites in a subject (e.g., levels of the chorismate metabolites in the gut) may have beneficial effects, prophylactic, and / or therapeutic effects for the subject, for example, in enhancing cognitive function or treating one or more signs or symptoms of a neurological disorder.

The invention relates to the technical field of organic synthesis, in particular to a preparation method of hexamethyl biphenol, which comprises the following steps: under the combined action of an alkaline environment, an oxidant and a catalyst, trimethylphenol is subjected to oxidative coupling reaction to obtain an intermediate, and the intermediate is reduced to obtain hexamethyl biphenol; the catalyst is an Ag-Cu-SAPO-34 molecular sieve. The method provided by the invention has the advantages that the catalyst is easy to separate, toxic and harmful substances are not generated, the subsequent treatment is simple, the method is suitable for large-scale industrial production, the reaction yield is high, and the product purity can reach 98% or above.

The application discloses a method for preparing 1,4-naphthoquinone by oxidizing naphthalene. The method comprises the following steps: mixing raw materials containing naphthalene and hydrogen peroxide with a solvent and a catalyst, and reacting to obtain a product containing 1,4-naphthoquinone. The synthesis method is simple, no heavy metal wastewater is discharged, is green, safe, environment-friendly, high in naphthalene conversion rate and 1,4-naphthoquinone selectivity, and is suitable for industrial production.

The present invention relates to novel combinations of redox active compounds for use as redox flow battery electrolytes. The invention further provides kits comprising these combinations, redox flow batteries, and method using the combinations, kits and redox flow batteries of the invention.

The present disclosure provides compounds of formula 1 to inhibit or prevent mitochondrial dysfunction by augmenting mitochondrial function. Mitochondrial dysfunction is the hallmark of a wide range of diseases and disorders. Mitochondria are a promising therapeutic target for the detection, prevention and treatment of various human diseases such as cancer, neurodegenerative diseases, ischemia-reperfusion injury, diabetes and obesity.

The invention belongs to the technical field of fine chemical engineering, and discloses a method for preparing 9, 10-anthraquinone through oxidation of 9, 10-dihydroanthracene, 9, 10-dihydroanthracene is taken as a raw material, tert-butyl hydroperoxide is taken as an oxidant, in a water phase reaction system, RuOx-Ce0. 7Zr0. 3O2 is taken as a catalyst, 9, 10-dihydroanthracene is subjected to selective oxidation under the mild conditions of 40 DEG C and normal pressure, the conversion rate of dihydroanthracene is 100%, and 9, 10-anthraquinone is prepared through oxidation of 9, 10-dihydroanthracene. And the selectivity of the 2, 10-anthraquinone is 90%. According to the present invention, the environmentally-friendly dihydroanthracene is adopted as the raw material to construct the green and efficient anthraquinone catalytic synthesis system, the traditional anthraquinone production process is replaced, the emission of the strong acid wastewater and the heavy metal wastewater is avoided, the reaction condition is mild, the conversion rate of the 9, 10-dihydroanthracene and the selectivity of the 9, 10-anthraquinone are high, and the good industrial application prospect is provided.

The application belongs to the technical field of fine chemical synthesis, and particularly relates to a preparation method of 3,3',5,5'-tetra-tert-butyl-4,4'-diphenyl-diphenol, which comprises the following steps: S1 raw material pretreatment: after 2,6-di-tert-butyl phenol is vacuum dried, a nano zinc oxide-montmorillonite composite catalyst is added and uniformly mixed; in the scheme, by adopting a double-catalyst system composed of a nano zinc oxide-montmorillonite composite catalyst and a TiO2 photocatalyst modified by carbon nitride quantum dots, a synergistic process of microwave-assisted oxidative coupling and photocatalytic reduction is combined, key parameters such as reaction temperature, pressure and time are optimized, and a multi-stage purification process of supercritical CO2 extraction-recrystallization is matched, so that efficient recovery and recycling of the catalyst are realized, high-quality products with a purity of greater than or equal to 99.5% and a colority of less than or equal to 8 (APHA) are finally prepared, the total reaction time is shortened to 6-7 hours, the number of times of repeated use of the catalyst reaches 5-8 times, and the efficiency, economy and product quality stability of the process are significantly improved.

Disclosed herein are embodiments of compounds that exhibit Crk-like protein inhibition. The compound embodiments can be used to suppress or prevent tumor cell growth, augmenting immune cell response in a subject having, or suspected of having, a chronic viral infection or a cancer, and / or to inhibit a Crk-mediated signaling pathway. Methods of making and using the compound embodiments are disclosed herein.

The present invention provides a method for synthesizing 2,3,5-trimethylbenzoquinone from 2,3,6-trimethylphenol by cobalt catalysis, belonging to the technical field of fine chemicals. This method uses 2,3,6-trimethylphenol as the raw material, molecular oxygen as the oxidant, and a cobalt-based material as the heterogeneous catalyst to prepare 2,3,5-trimethylbenzoquinone through a high-performance liquid-phase oxidation reaction. The preparation method of the used cobalt-based material is simple. First, a precursor is obtained by mixing a certain proportion of cobalt salt and a nitrogen-containing organic ligand, and then the precursor is heat-treated in an inert atmosphere at 300-450 °C to obtain the cobalt-based catalyst. The oxidation reaction process of the present invention has mild conditions, is safe, environmentally friendly, the catalyst and the product are easy to separate from the reaction system, and has remarkable practicability and broad application prospects.

The invention provides a preparation method of 2, 3, 5-trimethylbenzoquinone capable of reducing chlorinated impurities. The preparation method comprises the following steps: reacting chlorinated 1-butyl-3-methylimidazolium salt with Lewis acid in a solvent A under the action of acid to obtain an ionic liquid catalyst; in a solvent B, under the action of an ionic liquid catalyst and acid, 2, 3, 6-trimethylphenol is oxidized to prepare the 2, 3, 5-trimethylbenzoquinone. The preparation method disclosed by the invention is simple, simple and convenient to operate, low in discharge amount of three wastes, green, safe, environment-friendly, low in cost, high in product yield, purity and content, free of chlorinated impurities and suitable for industrial production, and process conditions are easy to realize;

The invention belongs to the technical field of fine chemical synthesis, and particularly relates to a preparation method of 3, 3 ', 5, 5'-tetra-tert-butyl-4, 4 '-biphenol, which comprises the following steps: S1, raw material pretreatment: carrying out vacuum drying on 2, 6-di-tert-butylphenol, adding a nano zinc oxide-montmorillonite composite catalyst, and uniformly mixing; according to the scheme, a dual-catalysis system composed of a nano zinc oxide-montmorillonite composite catalyst and a carbon nitride quantum dot modified TiO2 photocatalyst is adopted, a microwave-assisted oxidative coupling and photocatalytic reduction synergistic process is combined, key parameters such as reaction temperature, pressure and time are optimized, a supercritical CO2 extraction-recrystallization multi-stage purification process is matched, and the high-purity TiO2 photocatalyst is obtained. Meanwhile, efficient recovery and recycling of the catalyst are achieved, a high-quality product with the purity larger than or equal to 99.5% and the chromaticity smaller than or equal to 8 (APHA) is finally prepared, the total reaction time is shortened to 6-7 hours, the number of times of repeated use of the catalyst reaches 5-8, and the efficiency, economical efficiency and product quality stability of the process are remarkably improved.

The present invention discloses a 1,4,5,8-phenanthrene diquinone active substance, an organic positive electrode material and an aqueous zinc battery. The organic positive electrode material containing the 1,4,5,8-phenanthrene diquinone active substance designed in the present application has a π conjugated structure, and utilizes carbonyl and Zn 2+ The reversible redox reaction between the two materials realizes the rapid storage of electrical energy, making it have excellent conductivity and structural stability, significantly improving the specific capacity, energy density and cycle stability of organic positive electrode materials. Specifically, the aqueous zinc battery electrode based on 1,4,5,8-phenanthrene diquinone active material is 0.64A g ‑1 The maximum specific capacity at the current density is 412.28 mAh g ‑1 When the current increases 100 times, the specific capacity is still 138.95 mAh g ‑1 At the same time, the aqueous zinc battery is at 5.13A g ‑1 After 1000 cycles at a current density of 222.11 mAh g ‑1 The specific capacity of the battery is as high as 71.62%, and the coulombic efficiency is still 100% after 1000 cycles, showing excellent electrochemical performance.

The present invention relates to a process of manufacturing 2,3,5-tri- methylhydroquinone from a mixture of mesitol and 2,3,6-trimethylphenol (=2,3,6- TMP). This process offers a highly interesting and commercial interesting way of producing α-tocopherol.

The invention discloses a preparation method of idebenone, which comprises the following steps: S1, carrying out Sonogashira coupling reaction on 2-iodo-3, 4, 5-trimethoxytoluene and 9-decyne-1-alcohol in an aprotic solvent under the catalytic action of bis (triphenylphosphine) palladium chloride, cuprous iodide and organic alkali to obtain an alkynyl intermediate IM 1; s2, carrying out catalytic hydrogenation reduction on the intermediate IM 1 in a protic solvent by using palladium carbon to obtain an unoxidized intermediate IM 2; and S3, oxidizing the intermediate IM 2 in a tetrahydrofuran aqueous solution by using potassium hydrogen peroxymonosulfate to obtain the final product idebenone. According to the preparation method of idebenone, provided by the invention, the conversion rate of reaction is effectively improved, the reaction steps are reduced, the operation of purifying an intermediate is omitted, the product yield is high, the process is simple, the operation is convenient and fast, and large-scale industrial production is facilitated.