15 results about "Benzoquinone Compound" patented technology

The application discloses a tobacco endophytic fungus metabolite, a preparation method and application in tobacco alternaria alternata prevention and treatment, and relates to the technical field of microbial natural product pesticides. The tobacco endophytic fungus metabolite is a benzoquinone compound peniquinone L, and a structural formula is as follows: The benzoquinone compound peniquinone L is produced by fermentation of tobacco endophytic fungus Aspergillus aculeatus Aspergillus aculeatus Aa-1, and scale fermentation and preparation production are easy to carry out. The tobacco endophytic fungus metabolite benzoquinone compound peniquinone L of the application has inhibitory activity on various agricultural pathogens, and has significant bacteriostatic activity on tobacco alternaria alternata in particular, with an MIC value of 2 μg / mL, which is superior to positive drug carbendazim, and can be used as a leading compound or a new microbial natural product pesticide for tobacco alternaria alternata prevention and treatment.

The present invention relates to microbial metabolites and their application technology in the research field of agricultural fungal control drugs, specifically an application of a chloro-p-benzoquinone compound. The application of a chloro-p-benzoquinone compound as a new control drug for agricultural fungi. The chloro-p-benzoquinone compound is 2-chloro-5-methoxy-3-methylcyclohexa-2,5-diene-1,4-dione, as shown below #imgabs0# The chloro-p-benzoquinone compound involved in the present invention (as shown in structural formula I) can be used as a new drug ingredient or lead compound for resisting agricultural fungi. The chloro-p-benzoquinone compound involved in the present invention has significant anti-agricultural fungal activity, and its mechanism of action can be further explored in order to develop it into a new pesticide or its lead compound.

The preparation method comprises the following steps: adding copper sulfate into a PBS (Phosphate Buffer Solution) containing BSA (Bovine Serum Albumin), standing for 2 hours, carrying out centrifugal separation, and drying to prepare BSA-Cu3 (PO4) 2 hybrid nanoflowers, as a nano-enzyme for simulating a binuclear copper active center structure of tyrosinase, the nano-enzyme has the advantages of high surface area, efficient catalytic activity and high stability, then a solid salt hydrate is added to provide active water similar to the action of a cofactor in enzyme catalysis, natural polyphenol is catalyzed to be oxidized in an organic phase to generate an o-benzoquinone compound to serve as a hydrophobic part, and the activity of the o-benzoquinone compound is improved. A primary product obtained by ethanol separation is subjected to a Michael addition reaction with leucine, melanogenesis is simulated, the amino acid surfactant is biomimetic synthesized, and the obtained product has excellent surface performance.

The patent relates to a method for preparing marine terpenoid natural products based on a decarboxylation coupling reaction of carboxylic acid salt of sclareolide or carboxylic acid of sclareolide and quinone compounds, and belongs to the field of chemical synthesis. The method takes sclareolide as raw material, and realizes, for the first time, a Minisci decarboxylation coupling reaction of carboxylic acid salt of bicyclic sesquiterpene or carboxylic acid of sclareolide and p-benzoquinone promoted by Selectfluor, so that the synthesis steps of yahazunone are shortened from the previous 6-18 steps to 2 steps, and asymmetric synthesis of multiple yahazunone natural products is realized. The method has the characteristics of good step economy, simple operation and suitability for industrial production.

The present invention discloses a green co-production method for benzoquinone compounds and hydroquinone. This method involves a phenolic compound and benzoquinone undergoing a redox reaction in a protonic acid catalyst and a solvent, wherein the solvent comprises at least one of water and an alcohol solvent, to produce the benzoquinone compounds and hydroquinone. This method couples the production of trimethylbenzoquinone, which originally requires oxidation with an oxidant, with the production of hydroquinone, which requires reduction with hydrogen. Using an inexpensive acid as a catalyst for the redox reaction, the method simultaneously produces two important chemical products. The method boasts high catalytic efficiency and a high co-production yield, helping to reduce the production costs of trimethylbenzoquinone and hydroquinone and minimizing environmental pollution.

The application provides a synthesis method of a spiropyran compound and belongs to the technical field of organic synthesis chemistry, and aims at solving the technical problems of difficult synthesis of a spiro ring skeleton and complex steps. In the application, reactants, an oxazine compound, a 1,4-benzoquinone compound and a catalyst and an additive are added into a solvent to react under an inert atmosphere, and the spiropyran compound is prepared after the reaction is completed. In the application, the simple and easily obtained oxazine compound and the 1,4-benzoquinone compound are selected as the reactants, the construction of a novel spiro[5.5]heterocyclic skeleton containing a quaternary carbon center is realized through [3+3] in the action of a metal ruthenium catalyst, a simple and effective synthesis method for the construction of a complex spiro ring is provided, and the method has the characteristics of mild reaction condition, simple operation, atom economy, step economy and strong functional group tolerance.

The invention discloses a synthesis method of a benzoquinone compound, which comprises the following steps: adding a compound A, a copper salt catalyst and an initiator AIBN into an organic solvent, introducing oxygen for reaction to obtain a precipitate, then evaporating the solvent to dryness to obtain a crude product, separating the precipitate, washing and drying to obtain a compound B; the raw material cost is low, the synthesis route is simple, the purity of the obtained benzoquinone compound is high by precisely regulating and controlling the reaction conditions, and the strict requirements of most of downstream industrial applications on the purity of the raw materials can be met.

The invention discloses a synthesis method of a benzoquinone compound, which is characterized in that a metal-Schiff base complex and a derivative thereof are used as a catalytic system, oxygen is used as a green oxidant, a polar aprotic solvent is used as a medium, and the efficient synthesis of the benzoquinone compound is realized under the mild condition of 20-90 DEG C. Experiments show that the catalytic system effectively regulates and controls an activation path of a phenolic substrate through a synergistic effect of a ligand electron effect and steric hindrance, so that the conversion rate of an ortho-substituted phenolic compound and the selectivity of a target product are improved. Compared with a traditional system, the catalyst shows excellent catalytic cycle stability and specific recognition capability on o-cresol substrates, and the catalytic efficiency of the catalyst is improved. The technical route has the advantages of high economical efficiency, recyclability and the like, conforms to the green chemistry principle, and provides an innovative solution for industrial preparation of benzoquinone fine chemicals.

Disclosed in the present invention is an environmentally-friendly method for co-producing a benzoquinone compound and hydroquinone. The method comprises subjecting a phenolic compound and benzoquinone to an oxidation-reduction reaction in a protonic acid catalyst and a solvent to generate a benzoquinone compound and hydroquinone, wherein the solvent comprises at least one of water or an alcohol solvent. In the method, trimethylbenzoquinone production, which originally requires oxidation by means of an oxidizing agent, is coupled with hydroquinone production, which requires reduction by means of hydrogen, and an inexpensive acid (I) is used as a catalyst to perform an oxidation-reduction reaction; and two important chemical products are obtained at the same time, the catalytic efficiency is high, and the co-production yield is high. Therefore, the method is beneficial for lowering the production costs of trimethylbenzoquinone and hydroquinone, and reducing environmental pollution.

The present invention provides a microreactor and a method for synthesizing diphenol compounds using the same, belonging to the field of fine chemical synthesis. The microreactor includes a micro-packed bed reactor or a microchannel reactor, the micro-packed bed reactor includes a micro-packed bed reactor inlet and a micro-packed bed reaction tube connected in sequence; the microchannel reactor includes a micro-channel reactor inlet and a microchannel reaction tube connected in sequence; the micro-packed bed reactor inlet or the microchannel reactor inlet includes a gas-liquid mixing unit. During synthesis, the reaction liquid of the phenol compound and the oxidizing reaction gas are introduced into the microreactor for oxidation reaction to obtain an intermediate product, a benzoquinone compound, which is then hydrogenated, evaporated, and crystallized to obtain the intermediate product; the diphenol compound includes hydroquinone and / or tert-butylhydroquinone. The reactor of the present application has a simple structure, promotes gas-liquid mass transfer, reduces the reactor volume, and greatly improves the efficiency and safety of the process.

The present application belongs to the technical field of organic compound synthesis, and relates to a method for synthesizing 3-indolyl benzoquinone compounds, which is used to solve the technical problems that the preparation of the existing 3-indolyl benzoquinone compounds needs additional oxidants or a large amount of hydroquinone by-products is inevitably generated in the reaction system due to the use of more than 2 equivalents of benzoquinone compounds. The method is that: in an oxygen or air environment, a C2 substituted indole compound and a hydroquinone compound are reacted in a mixed solution of water and an organic solvent with Salcomine as a catalyst to generate a 3-indolyl benzoquinone compound. The catalyst system of the present application is simple, the reaction selectivity is excellent, the by-products are few, and the reaction efficiency is high; the synthesis process is simple, the waste is little, the environment is friendly, and the present application has a strong industrial application prospect.

The utility model belongs to the technical field of material separation, and particularly relates to a stripping separation device for p-benzoquinone compounds, which comprises a stripping tower, a primary condensation assembly, a secondary condensation assembly, a vacuum buffer tank, a gas-liquid separation assembly and a tail gas absorption tower, the first-stage condensation assembly is connected with the second-stage condensation assembly through a first-stage condensation gas outlet pipeline, the second-stage condensation assembly is connected with the vacuum buffer tank through a second-stage condensation gas outlet pipeline, and the vacuum buffer tank is connected with the gas-liquid separation assembly through a vacuum gas outlet pipeline. The gas-liquid separation assembly is connected with the tail gas absorption tower through a gas-liquid separation gas outlet pipeline. According to the utility model, the problem of carbonization of p-benzoquinone compounds due to overhigh temperature can be solved by reducing the distillation temperature of the tower top.

The invention relates to a bisbenzoquinone compound and a preparation method and application thereof.The bisbenzoquinone compound is separated from a fermentation product of chaetomium trilateral, has a brand-new chemical structure, has remarkable inhibitory activity on proliferation of multiple tumor cells, and reaches the nM-level inhibitory activity.

The application discloses a method for detecting the content of benzoquinone compounds in wood and relates to the technical field of chemical analysis. The method comprises the following steps: adding a wood sample to be detected into a toluene solvent for extraction to obtain a benzoquinone compound extraction liquid; and performing gas chromatography-mass spectrometry detection on the benzoquinone compound extraction liquid obtained in step S1, wherein the detected benzoquinone compounds are 2,3-dimethoxy-5-methyl-1,4-benzoquinone and / or 2,6-dimethoxy-1,4-benzoquinone. The detection limit of 2,3-dimethoxy-5-methyl-1,4-benzoquinone is as low as 0.0883 mg / kg, and the standard addition recovery rate is 97.6% to 103.7%; the detection limit of 2,6-dimethoxy-1,4-benzoquinone is as low as 0.0888 mg / kg, and the standard addition recovery rate is 99.8% to 101.3%.

The invention relates to the field of high-value utilization of biomass, in particular to a method for polymerizing and depolymerizing lignin into a benzoquinone compound and a depolymerizing method of the benzoquinone compound. Lignin or a lignin model compound is used as a raw material and is subjected to lignin oxidative depolymerization reaction under the action of an oxidizing agent and a mixed solvent; benzylic hydroxyl of lignin generates benzylic carbocations under the action of a solvent, then the benzylic carbocations are combined with an oxidizing agent to generate an oxide intermediate, and the benzoquinone compound and byproducts thereof are obtained through an intramolecular rearrangement reaction and oxidation of the oxidizing agent. The depolymerization method for polymerizing and depolymerizing lignin into the benzoquinone compound provided by the invention is low in cost, simple in operation and reaction conditions, green and renewable in raw materials, cheap and green in oxidant, high in depolymerization efficiency and wide in lignin universality, and solves the problems that the preparation raw materials for producing the benzoquinone compound in the current industry are non-renewable and non-sustainable, and the cost is low. The energy consumption is high; the post-treatment is difficult, and the like.