39 results about "1,4-Benzoquinone" patented technology

The invention describes a pharmaceutical composition and method for treating cancer comprised of A) 2,3-dimethoxy-5-methyl-1,4-benzoquinone and/or B) at least one of wild yam root, teasel root, balm of gilead bud, bakuchi seed, dichroa root, kochia seed, kanta kari, bushy knotweed rhizome, arjun, babul chall bark, opopanax and bhumy amalaki; optionally one or more of frankincense, garcinia fruit, vitex, dragons blood, mace, sage and red sandalwood with at least c) one compound capable of maximizing oxidative mitochondrial function preferably riboflavin or vitamin B₂ derivatives, FAD, FMN, 5-amino-6-(5′-phosphoribitylamino)uracil, 6,7-Dimethyl-8-(1-D-ribityl)lumazine, ribitol, 5,6-dimethylbenzimidazole, tetrahydrobiopterin, vitamin B₁, lipoic acid, biotin, vitamin B₆, vitamin B₁₂, folate, niacin, vitamin C and pantothenate and/or d) at least one lactic acid dehydrogenase inhibitor (preferably 2′,3,4′5,7-pentahydroxyflavone) and optionally f) an alkalizing agent (aloe vera, chlorella, wheat grass, sodium or potassium bicarbonate, potassium) g) an antiproliferative herb (speranskia or goldenseal) and h) a pharmaceutically acceptable carrier.

The invention describes a nutraceutical composition and method for preventing/treating cancer comprised of A) quinones (2,3-dimethoxy-5-methyl-1,4-benzoquinone, thymoquinone, tocopherolquinone) B) compounds capable of maximizing oxidative mitochondrial function preferably riboflavin, FAD, FMN, 6,7-Dimethyl-8-(1-D-ribityl)lumazine, ribitol, 5,6-dimethylbenzimidazole, tetrahydrobiopterin, vitamin B₁, lipoic acid, biotin, vitamin B₆, vitamin B₁₂, folate, B3, C and pantothenate C) lactic acid dehydrogenase inhibitors; 2′,3,4′5,7-pentahydroxyflavone, epigallocatechin gallate, quercetin, citric acid, rosemary, black walnut, clove, nutmeg, licorice root, coriander, cinnamon, ginger root, myrrh gum and green tea D) alkalizing agents: aloe vera, chlorella, wheat grass, apple cider vinegar, burdock root, kudzu root, alfalfa, barley grass, spirulina, parsley leaf, calcium, magnesium, potassium or bicarbonate salts E) potent tumoricidal herbs; gromwell root, wild yam, beth root, teasel root, balm of gilead bud, frankincense, bakuchi seed, dichroa root, kochia seed, kanta kari, sweet myrrh, galbanum, garcinia fruit, mace, white sage and tumoricial plant derived constituents: gambogic acid, shikonin, diosmin or boswellic acid F) an antiproliferative herb (speranskia or goldenseal) and G) a pharmaceutically acceptable carrier.

The invention relates to a novel red BODIPY fluorescent dye with the chemical formula of C10+mH7+nBF2N2+xOy, wherein m, n, x and y are integers from 0 to 100. The preparation method comprises the following steps: dissolving pyrrole with substituent groups R1, R2 and R3 in an organic solution; adding ethyl glyoxylate together with nitrogen to the organic solution for a chemical reaction by using trifluoroacetic acid or toluenesulfonic acid as a catalyst; adding 2,3-dichloro-5,6-dicyano-1,4-benzoquinone oxidative dehydrogenation; and adding organic amine and a boron trifluoride diethyl ether solution for another reaction. After the reaction solution is concentrated, chromatography is performed with a silicagel column to obtain the fluorescent dye. The fluorescent dye can be used for cell imaging, fluorescent probe or laser dye. The fluorescent dye has the advantages that the ultraviolet-visible absorption spectrum and the fluorescence emission spectrum of the fluorescent dye are narrow; fluorescent quanta has high efficiency and good light stability; and the fluorescent dye has simple molecular structure and can be synthesized easily, so as to facilitate popularization and application.

The invention relates to a novel BODIPY flourescent dye with an adjustable emission wavelength. The chemical formula of the novel BODIPY flourescent dye is C15+mH6+nBF7N2+xOy, wherein m, n, x and y are integers from 0 to 100. The preparation method comprises the following steps of: dissolving pentafluorobenzaldehyde into an organic solvent, adding pyrrole with substituent groups R1, R2, R3 in the presence of nitrogen, and reacting by taking trifluoroacetic acid or para-toluenesulfonic acid as a catalyst; then adding 2,3-dichloro-5,6-dicyano-1,4-benzoquinone for oxidative dehydrogenation; and finally adding organic amine and boron trifluoride diethyl etherate solutions for continuous reaction, and concentrating a reaction liquid to obtain a target object by utilizing silica gel column chromatography. The novel BODIPY flourescent dye disclosed by the invention can be used for cell imaging and the like, can be adjusted in emission wavelength from a visible region to a near-infrared region and has the advantages of narrow fluorescence emission spectrum, high fluorescence quantum efficiency, good light stability, simple molecular structure, easiness and convenience for synthetic method and easiness for popularization and application.

The present invention relates to an improved process for the preparation of Coenzyme Q. Coenzyme Q₁₀ or CoQ₁₀ has the chemical name 2-[(all-trans)-3,7,11,15,19,23,27,31,35,39-decamethyl-2,6,10,14,18,22,26,30,34,38-tetracontadecaenyl]-5,6-dimethoxy-3-methyl-1,4-benzoquinone and has the formula I.

The invention also provides new intermediates useful for the preparation of CoQ₁₀ and processes for their preparation.

The present invention provides a positive electrode active material for nonaqueous solvent secondary batteries, comprising, as an active ingredient, a 1,4-benzoquinone compound having lower alkoxy groups as substitutes, and a nonaqueous secondary battery comprising the positive electrode active material as a constituent. According to the invention, a nonaqueous secondary battery having a high energy density and excellent cycle characteristics can be obtained by using a positive electrode active material composed of an organic compound with a low environmental load.

It is an object to provide a non-aqueous electrolyte for use in a primary battery, which is advantageous in that the primary battery using the non-aqueous electrolyte suffers less lowering of voltage during the high-rate discharge and can work stably. Disclosed are a non-aqueous electrolyte for use in a primary battery, comprising at least one organic compound selected from the group consisting of 1,2-benzoquinone, 1,4-naphthoquinone, 1,2-naphthoquinone, 9,10-anthraquinone, 1,4-anthraquinone, acenaphthenequinone, and a derivative of 1,2-benzoquinone, 1,4-naphthoquinone, 1,2-naphthoquinone, 9,10-anthraquinone, 1,4-anthraquinone, acenaphthenequinone, or 1,4-benzoquinone; a non-aqueous electrolyte for use in a primary battery, comprising an organic compound exhibiting a reduction potential of 2.5 V or higher and a quantity of electricity in reduction reaction per electrode area of 1,000 mC/cm² or lower under specific conditions; and a non-aqueous electrolyte for use in a primary battery, having a reduction potential of 2.5 V or higher and a quantity of electricity in reduction reaction per electrode area of 1,000 mC/cm² or lower.

Disclosed herein are compounds and methods of using such compounds for treating or suppressing oxidative stress disorders, including mitochondrial disorders, impaired energy processing disorders, neurodegenerative diseases and diseases of aging, or for modulating one or more energy biomarkers, normalizing one or more energy biomarkers, or enhancing one or more energy biomarkers, wherein the compounds are tocopherol quinone derivatives. Further disclosed are compounds, compositions, and methods for treatment of, or prophylaxis against, radiation exposure.

The invention discloses a synthesis method of a 2,5-bis(substituted amino)-1,4-benzoquinone compound. The method comprises the following steps of: dissolving hydroquinone in a polar solvent, diluting aliphatic or aromatic primary amine and secondary amines with a polar solvent, dripping diluted aliphatic or aromatic primary amine and secondary amines to a hydroquinone solution to obtain a mixed solution, heating the mixed solution in a water bath and finally separating reaction liquid to obtain a product. The synthesis method provided by the invention, with inexpensive hydroquinone, aliphatic or aromatic primary amine and secondary amines as raw materials, overcomes the defect that the synthesis method in the prior art has high production cost or low yield, embodies green, energy-saving and environmental protection concepts, and has high potential application value.

Use of idebenone for the preparation of a medicament for transmucosal administration.

The invention discloses a preparation method of a permanent violet pigment. The method comprises the following steps: dissolving 3-amino-N-ethyl carbazole in an organic solvent and carrying out a condensation reaction by adding chloranil in the presence of an acid-binding agent so as to obtain an organic solution containing 2,5-dichloro-3,6-di(9-ethyl-3-carbazole amino)-1,4-benzoquinone after the reaction; adding a metal salt catalyst into the organic solution obtained in the step a or simultaneously adding the metal salt catalyst and a quinone compound cocatalyst into the organic solution; feeding air or oxygen into a reaction kettle to reach a certain pressure; carrying out heat preservation at 120-180 DEG C for 2-10 hours; cooling to 80-120 DEG C after the reaction; washing a filter cake obtained after filtering with a small amount of organic solvent; then, respectively washing with methyl alcohol and water and drying, thereby obtaining a crude permanent violet pigment product. According to the method, a traditional poisonous and harmful closed-loop agent is not adopted, so that the cost of raw materials is saved; the generation of byproducts is reduced, so that the selectivity and total yield of the reaction are improved. Thus, less environmental pollution is generated.

The present invention relates to a transmucosal administration system to administer quinones, benzoquinones, and especially 1,4-benzoquinones, via the oromucosal route.

The present invention relates to a process for the conversion of phenol to hydroquinone and quinones. More particularly this invention relates to a process for the oxidation of phenol to a mixture of 1,4-benzoquinone and hydroquinone using an oxidant in the presence of titanium superoxide as a reusable catalyst in a liquid phase condition.

The present invention relates to approaches, methods, pharmaceuticals and uses directed to the curative treating or preventing of Primary Progressive Multiple Sclerosis (PP-MS), by using 2,3-dimethoxy-5-methyl-6-(10-hydroxydecyl)-1,4-benzoquinone (Idebenone) as the active agent.

A gluten-free grain concentrate (GFGC) food product and stepwise process to prepare GFGC from the treatment of raw unground wheat germ, is provided resulting in a product having at least three active components including (a) 1% to 3% 2,6-dimethoxy-1,4-hydroquinone; (b) 2% to 4% monomethoxy-1,4-benzoquinone; and (c) 0.5% to 1.5% monomethoxy-1,4-hydroquinone; and at least one inactive component: 2,6 dimethyl benzoquinone.

The invention discloses a preparation method of 2-methyl-3-methoxy-carbazole-1,4-benzoquinone. In the preparation method, 3-bromo-N-Ts indole reacts with 3-methoxy-4-methyl-3-cyclobutene-1,2-diketone to obtain 2-methyl-3-methoxy-carbazole-1,4-benzoquinone, wherein Ts is p-toluenesulfonyl. In the invention, a natural product 2-methyl-3-methoxy-carbazole-1,4-benzoquinone is synthesized by use of commercially available raw materials; the preparation method is simple and realizes convenient separation, high yield and good selectivity.

The present invention discloses a synthesis method for a triphyrin compound with no center coordination. According to the present invention, the adopted mixed oxidant is tetrachlorobenzoquinone and 2,3-dichloro-5,6-dicyano-1,4-benzoquinone, and the oxidation time is prolonged so as to significantly improve the synthesis yield of the triphyrin with no center coordination and simplify the process treatment. The synthesis method can be applied for synthesis of the triphyrin compound with no center coordination.

The invention discloses a synthetic method of 1, 2-diol dicarboxylic ester. The method comprises the following step: by taking 2,3-dichloro-5, 6-dicyan-1,4-benzoquinone as a dehydrogenation agent, carrying out reaction on cycloacetal and carboxylic acid in a dried organic solvent for 6-48 hours at 20-140 DEG C to obtain 1, 2-diol dicarboxylic ester, wherein the molar ratio of cycloacetal to carboxylic acid is (1-10): 1 and the molar ratio of the dehydrogenation agent to carboxylic acid is (1-10): 1. The method overcomes the defects that in the prior art, a strong acid or an expensive coupling agent is required, monoester needs to be pre-prepared when asymmetrical dicarboxylic ester is synthesized, and 1,2-diol in the process is excessive in amount and the like. The synthetic method has the advantages that 1) by taking 2,3-dichloro-5,6-dicyan-1,4-benzoquinone as the dehydrogenation agent, non-metal coupling is realized, and heavy metal ions are prevented from being left in a product; 2) the reaction product is easy to separate and the dehydrogenation agent is easy to regenerate; 3) the process is simple, the cost is low, the product is good in specificity and environmental-friendly; and 4) the conversion efficiency is high. The synthetic method disclosed by the invention plays an important role in industrial production of 1, 2-diol dicarboxylic ester.