2 results about "Dimethylbenzimidazole" patented technology

This invention belongs to the field of biomedical technology, specifically relating to the application of 5,6-dimethylbenzimidazole in the preparation of drugs for treating colorectal cancer. Through this invention, it was found that 5,6-dimethylbenzimidazole can significantly inhibit the proliferation, colony formation, and migration of colorectal cancer cells in a concentration-dependent manner. In an in vivo tumor-bearing model, it inhibits tumor growth and reduces the expression of the proliferation marker Ki-67, and shows no significant organ toxicity to the liver, spleen, and kidneys of mice, indicating that 5,6-dimethylbenzimidazole has good safety. Furthermore, its specific mechanism of action was explored in depth. 5,6-dimethylbenzimidazole may exert its anti-tumor effect by regulating the HMOX1 / GPX4 related pathway, upregulating HMOX1 and downregulating GPX4, promoting ferroptosis in colorectal cancer cells and transplanted tumors.

This invention belongs to the field of rare earth-transition complex preparation technology, and discloses a pentanuclear rare earth-transition heterometallic complex, its preparation method, and its applications. The preparation method provided by this invention is as follows: Dy(CF3SO3)3, NiCl2·6H2O, and ligand H2L (1,2-di(1-methyl-1H-benzo[d]imidazol-2-yl)ethane-1,2-diol) are mixed and dissolved in CH3OH and H2O in a certain proportion. Then, Et3N and NaN3 are added. The mixed solution is stirred at 80°C, allowed to stand and evaporate, and the reaction is completed to obtain blue blocky crystals. This pentanuclear rare earth-transition heterometallic complex has a bow-tie-shaped metallic framework structure and can be applied to the preparation of molecular magnetic materials and molecular memory materials.