14 results about "Dimethylbenzimidazole" patented technology

The invention belongs to the technical field of high-temperature-resistant coatings, and particularly relates to a core-shell polyimide-based high-temperature-resistant water-based coating and a preparation method thereof. Comprising the following components in percentage by mass: 35-38% of a core-shell emulsion; the core layer is polyimide resin; the transition layer is an organic silicon emulsion modified by 5, 6-dimethyl benzimidazole and a silane coupling agent KH-550; the shell layer is made of polyamide-imide resin; 28%-32% of a modified high-temperature filler; 6%-7.5% of a functional auxiliary agent; and the balance of deionized water. Through core-shell emulsion gradient design, multi-scale filler cooperation and a low-temperature gradient curing process, the high temperature resistance, the adhesive force and the environmental protection property of the coating are improved.

The invention discloses preparation of an antibacterial copper-based nano-enzyme fiber dressing capable of promoting wound healing, and belongs to the technical field of medical use. According to the method, 5, 6-dimethylbenzimidazole and copper salt are used as raw materials, the copper-based nano-enzyme is synthesized through a hot bath reaction method of a solvent, reactants are uniformly dispersed in a solution, and the defects that traditional nano-enzyme element components are not uniform, and active sites are low in density are overcome. The prepared copper-based nano enzyme has a unique metal active center, and has oxidase-like activity, catalase-like activity and superoxide dismutase-like activity. According to the copper-based nano-enzyme Cu-NPs II, the activity of oxidase can be achieved without hydrogen peroxide, active oxygen can be generated to achieve the bactericidal effect, when excessive ROS is generated, superoxide dismutase-like activity of the copper-based nano-enzyme Cu-NPs II converts the excessive ROS into H2O2, and due to the fact that the copper-based nano-enzyme Cu-NPs II has catalase-like activity and can decompose H2O2 into water and oxygen, the copper-based nano-enzyme Cu-NPs II has good microenvironment adjusting capacity.

The present application belongs to the technical field of high-temperature-resistant coatings, and particularly relates to a core-shell polyimide-based high-temperature-resistant water-based coating and a preparation method thereof. The coating comprises the following components by mass percentage: core-shell emulsion 35-38%, wherein the core layer is polyimide resin, the transition layer is organic silicon emulsion modified by 5,6-dimethylbenzimidazole and silane coupling agent KH-550, and the shell layer is polyamide-imide resin; modified high-temperature filler 28-32%; functional additive 6-7.5%; and deionized water in the rest. The present application improves the high-temperature resistance, adhesion and environmental friendliness of the coating through gradient design of the core-shell emulsion, synergistic effect of multi-scale fillers and low-temperature gradient curing process.

This invention discloses a novel iron-based supramolecular catalyst and its preparation method. A fluoroboron pyrrole (Bodipy) organic photosensitizer with strong visible light absorption and a long excited-state lifetime is covalently coupled to an inexpensive iron-based tetrapyridine catalyst via a click reaction, shortening the distance between the photosensitizer and the catalyst to construct a non-precious metal supramolecular photocatalytic system with strong visible light absorption. Using 1,3-dimethylbenzimidazole as a sacrificial agent, the catalyst exhibits high catalytic activity and selectivity in photocatalytic carbon dioxide reduction. The reaction system is low-cost and has promising application prospects.

The invention belongs to the technical field of antitumor drug research, and relates to a benzimidazolyl phenyl thiazole copper complex as well as a synthesis method and application of the benzimidazolyl phenyl thiazole copper complex. The benzimidazolyl phenyl thiazole copper complex CuL2Cl is synthesized from 2, 6-dimethyl-1H-benzimidazole-2-yl)-4-phenyl thiazole and copper chloride for the first time, and the benzimidazolyl phenyl thiazole copper complex CuL2Cl is synthesized from 2, 6-dimethyl-1H-benzimidazole-2-yl)-4-phenyl thiazole. Wherein L is 2-(5, 6-dimethyl-1H-benzimidazole-2-yl)-4-phenyl thiazole, and the structural formula is shown in the description. A test result shows that the copper complex has an inhibiting effect on a human liver cancer cell line HuH7, has the capability of inhibiting cancer cell invasion and migration, has the capability of inducing apoptosis of cancer cells and the capability of inducing cycle arrest of cancer cells, and can be used for preparing a medicine for treating liver cancer. The benzimidazolyl phenyl thiazole copper complex is proved to be an ideal novel anti-cancer drug.

The invention relates to the technical field of functional materials, in particular to a heteroporous fluorine-doped cation covalent organic framework material and a preparation method and application thereof.The heteroporous fluorine-doped cation covalent organic framework material comprises a D2h symmetric monomer and a C2 symmetric monomer, the D2h symmetric monomer is tetra-(4-aminobenzene) ethylene, the C2 symmetric monomer is a side functional monomer, and the side functional monomer is a fluorine-doped cation covalent organic framework material. The side functional monomer comprises one or two of a fluorine-containing monomer and a cationic monomer, the fluorine-containing monomer is 2 ', 3', 5 ', 6'-tetrafluoro-[1, 1 ': 4', 1 ''-terphenyl]-4, 4''-dicarboxaldehyde, and the cationic monomer is 4, 7-bis (4-formylphenyl)-1, 3-dimethyl-1H-benzo [d] imidazole-3-onium bromide. The problems that an existing COF material is poor in PFAS adsorption performance and single in adsorption type are solved, and long-chain PFAS and short-chain PFAS are efficiently adsorbed at the same time.

The application relates to the technical field of functional materials, in particular to a heteroporous fluorine-doped cationic covalent organic framework material and a preparation method and application thereof. 2h Symmetric monomers and C2 symmetric monomers, D 2h The symmetric monomer is tetra-(4-aminophenyl) ethylene, the C2 symmetric monomer is a side functional monomer, the side functional monomer comprises one or both of a fluorine-containing monomer and a cationic monomer, the fluorine-containing monomer is 2', 3', 5', 6'-tetrafluoro-[1,1':4',1"-terphenyl]-4,4"-dimethylformaldehyde, and the cationic monomer is 4,7-bis(4-formylphenyl)-1,3-dimethyl-1H-benzo[d]imidazol-3-bromonium. The application solves the problems that the existing COF material has poor PFAS adsorption performance and single adsorption type, and realizes simultaneous and efficient adsorption of long-chain and short-chain PFAS.

The invention belongs to the field of chemical synthesis, and relates to a production process for improving the purity of 5.6-dimethylbenzimidazole. The 2, 5, 6-dimethyl benzimidazole (5, 6-DMB) is a natural benzimidazole derivative, and is an important precursor substance for biological fermentation synthesis. The 5, 6-DMB is added into a culture medium for synthesizing the VB12 by microorganisms, so that the speed of synthesizing the VB12 by the propionibacterium can be increased. According to the present invention, the original preparation process is improved, the 4-chloro-1, 2-dimethyl benzene is adopted as the raw material, the reaction steps are shortened, the production process for improving the purity of 5.6-dimethyl benzimidazole is designed, and the important significance is provided for promoting the social development.

The invention belongs to the field of preparation of pharmaceutical compounds, mainly relates to 5, 6-dimethyl benzimidazole, and in particular relates to a synthesis process of 5, 6-dimethyl benzimidazole. Acetylation and nitration are completed by adopting a one-pot method, so that the reaction steps are reduced, the operation is simple, and the yield is improved. Meanwhile, the prepared Ru-Zn / ZSM-5 catalyst is large in specific surface area and high in porosity, the catalytic effect can be effectively improved through the synergistic effect between Ru-Zn metal, and the selectivity and the yield are improved. During preparation of the 5, 6-dimethyl benzimidazole, hydrochloric acid is used for auxiliary condensation in the final ring closing process, so that the yield of the 5, 6-dimethyl benzimidazole is increased. The invention solves the problems of complex process, difficulty in industrialization, low yield and the like in preparation of 5, 6-dimethylbenzimidazole, and has important significance in the field of drug synthesis.

The invention discloses preparation and application of a dye-sensitized photocatalyst based on metal polyphthalocyanine, and relates to the technical field of photocatalytic materials and new energy. Titanium dioxide (P25) serves as a carrier, metal polyphthalocyanine (MPPc) is loaded on the surface of the carrier through an in-situ polymerization method, a terpyridyl ruthenium complex (RuP) is further adsorbed to serve as a photosensitizer, and the ternary composite photocatalyst (RuP-P25-MPPc) is constructed. The catalyst can efficiently catalyze carbon dioxide to be reduced into carbon monoxide by taking N, N-dimethylformamide (DMF) as a solvent, 1, 3-dimethylbenzimidazole (BIH) as a sacrificial agent and phenol as a proton source under the irradiation of visible light. The introduction of metal polyphthalocyanine effectively improves the charge separation efficiency and provides abundant catalytic sites, the performance of the catalyst taking iron polyphthalocyanine (FePPc) as a base is optimal, and the CO generation rate can reach 207 [mu] mol g <-1 > h <-1 >. The catalyst is clear in structure, simple and convenient in preparation method and suitable for the field of solar-driven carbon dioxide resource utilization.

This invention belongs to the field of biomedical technology, specifically relating to the application of 5,6-dimethylbenzimidazole in the preparation of drugs for treating colorectal cancer. Through this invention, it was found that 5,6-dimethylbenzimidazole can significantly inhibit the proliferation, colony formation, and migration of colorectal cancer cells in a concentration-dependent manner. In an in vivo tumor-bearing model, it inhibits tumor growth and reduces the expression of the proliferation marker Ki-67, and shows no significant organ toxicity to the liver, spleen, and kidneys of mice, indicating that 5,6-dimethylbenzimidazole has good safety. Furthermore, its specific mechanism of action was explored in depth. 5,6-dimethylbenzimidazole may exert its anti-tumor effect by regulating the HMOX1 / GPX4 related pathway, upregulating HMOX1 and downregulating GPX4, promoting ferroptosis in colorectal cancer cells and transplanted tumors.

The invention belongs to the technical field of probes, and particularly relates to a fluorescence and mass spectrum double-sensibilization labeled probe as well as a preparation method and application thereof. The probe takes benzimidazole as a mother ring and carbohydrazide as a reaction group, and comprises a probe 1 and a probe 2, the probe 1 is iodinated 4-(1, 3-dimethyl-benzimidazole-2-yl) benzoyl hydrazine d0, the chemical structural formula of the probe 1 is shown in the specification, and X is H; the probe 1 is deuterated iodinated 4-(1, 3-dimethyl-benzimidazole-2-yl) benzoyl hydrazine d6, the probe 2 is deuterated iodinated 4-(1, 3-dimethyl-benzimidazole-2-yl) benzoyl hydrazine d6, the chemical structural formula is shown in the specification, and X is D. The method disclosed by the invention can be used for rapidly, accurately and sensitively labeling and detecting the active carbonyl compound, is particularly suitable for separation and detection of trace and trace micromolecular active carbonyl compounds in a complex system, can be used for fluorescence labeling and analysis of various fatty aldehydes in the research fields of life analysis, food analysis and the like, and has a wide application prospect.

This invention belongs to the field of rare earth-transition complex preparation technology, and discloses a pentanuclear rare earth-transition heterometallic complex, its preparation method, and its applications. The preparation method provided by this invention is as follows: Dy(CF3SO3)3, NiCl2·6H2O, and ligand H2L (1,2-di(1-methyl-1H-benzo[d]imidazol-2-yl)ethane-1,2-diol) are mixed and dissolved in CH3OH and H2O in a certain proportion. Then, Et3N and NaN3 are added. The mixed solution is stirred at 80°C, allowed to stand and evaporate, and the reaction is completed to obtain blue blocky crystals. This pentanuclear rare earth-transition heterometallic complex has a bow-tie-shaped metallic framework structure and can be applied to the preparation of molecular magnetic materials and molecular memory materials.

The invention discloses a preparation method of a dehydroepiandrosterone-3beta-ester-5, 6-dimethyl benzimidazole bromine salt derivative, which comprises the following steps: mixing dehydroepiandrosterone, chloroacetyl chloride, an organic solvent and an activating-acid-binding agent, and carrying out acetylation reaction to generate dehydroepiandrosterone-3beta-ester; mixing the dehydroepiandrosterone-3beta-ester, 5, 6-dimethyl benzimidazole and methylbenzene, and then carrying out a substitution reaction, so as to obtain the dehydroepiandrosterone-3beta-ester-5, 6-dimethyl benzimidazole, namely the dehydroepiandrosterone-3beta-ester-5, 6-dimethyl benzimidazole. And mixing the dehydroepiandrosterone-3beta-ester-5, 6-dimethyl benzimidazole, alkyl bromide and toluene, and then carrying out a salt forming reaction, so as to obtain the dehydroepiandrosterone-3beta-ester-5, 6-dimethyl benzimidazole bromine salt derivative, namely the dehydroepiandrosterone-3beta-ester-5, 6-dimethyl benzimidazole bromine salt derivative. The dehydroepiandrosterone-3beta-ester-5, 6-dimethyl benzimidazole bromine salt derivative obtained by the method has remarkable in-vitro tumor growth inhibition activity on human cancer cells, and the in-vitro tumor growth inhibition activity of the dehydroepiandrosterone-3beta-ester-5, 6-dimethyl benzimidazole bromine salt derivative is superior to that of an anti-cancer drug-cis-platinum (DDP); meanwhile, the preparation method provided by the invention is simple and convenient to operate and easy to implement.