30 results about "Dimethylbenzimidazole" patented technology

The invention describes a nutraceutical composition and method for preventing / treating cancer or augmenting chemotherapy in advanced stage malignancies; comprised of [1] tumoricidal herbs; beth root, galbanum, gromwell root, wild yam, balm of gilead bud, frankincense, [2] an antiproliferative herb; speranskia [3] a natural lactic acid dehydrogenase (LDH) inhibitor, 2′,3,4′5,7-pentahydroxyflavone or cinnamon, [4] alkalizing agents: calcium, magnesium, potassium or bicarbonate salts, barley grass, chlorella and spirulina [5] at least one quinone and [6] at least one agent capable of maximizing oxidative mitochondrial function preferably riboflavin, 6,7-Dimethyl-8-(1-D-ribityl)lumazine, ribitol, 5,6-dimethylbenzimidazole, tetrahydrobiopterin and a pharmaceutically acceptable carrier.

The invention discloses a series of isomannide-bis-benzimidazole salt compounds having a structural general formula (as in figure 1) and a preparation method thereof; isomannide, as a raw material, and 4-toluene sulfonyl chloride are converted into isomannide p-toluenesulfonate under dichloromethane and anhydrous pyridine, the isomannide p-toluenesulfonate and benzimidazole or 5,6-dimethylbenzimidazole are subjected to thermal reaction in anhydrous DMF (dimethylformamide) solvent to synthesize isomannide-bis-benzimidazole, and on such basis, the isomannide-bis-benzimidazole and alkyl bromide are subjected to reflux reaction in acetonitrile solvent to synthesize isomannide-bis-benzimidazole salt compounds. Results of in-vitro antitumor active cytotoxicity test indicate that part of the compounds have good cytotoxicity.

The invention discloses a benzimidazole binuclear zinc metal complex and an application of the complex in a PVC (polyvinyl chloride) thermal stabilizer. The benzimidazole binuclear zinc metal complex Zn2L2(H2PO3)4 is prepared by the following steps: firstly, by using m-phthalic acid and 4, 5-dimethyl o-phenylenediamine as an initial raw material and polyphosphoric acid as a solvent and a catalyst, preparing a benzimidazole ligand 1, 3-di(2-(5, 6-dimehtyl benzimidazole)) benzene (ligand L); and preparing the complex by means of a simple solution method. By using the benzimidazole binuclear zinc metal complex Zn2L2(H2PO3)4 as a main raw material which is supplemented with other co-stabilizers to prepare a compound stabilizer, and the compound stabilizer is added into PVC to synergically improve the thermal stability of PVC. For 100 parts of PVC by weight, the additive amount of the complex is 0.2-3.5 parts by weight, preferably 0.5-1.5 parts by weight. The thermal stabilizer disclosed by the invention is convenient to prepare, can be used for improving the stainability of PVC and the long-term thermal stability, and has a good application prospect.

The invention discloses a 11, 12-dimethyl benzimidazole-1, 8-naphthalimide-platinum complex and a preparation method and application thereof. The preparation method of the complex mainly comprises: putting compounds shown in the formulas (II) and (III) into an organic solvent, and performing a coordination reaction process under heating or no heating to obtain a desired product. Compared with thecommon antitumor drug cisplatin, the complex has higher inhibitory activity to some cancer cells and lower toxicity to human liver normal cells HL-7702. The structure of the complex is shown in the formula (I). The raw materials for preparation of the complex are shown in the formulas (II) and (III).

The invention discloses a series of N-alkyl substituted indole-imidazolium salt compounds having a structural formula (represented b figure I), and a preparation method thereof. The preparation method comprises the following steps: synthesizing N-alkyl substituted indole from indole used as a raw material and dibromoalkane in an anhydrous DMF solvent, carrying out a heating reaction on the N-alkyl substituted indole and 5,6-dimethylbenzimidazole in a toluene solvent to synthesize N-alkyl substituted indole-imidazole, and carrying out a refluxing reaction on the N-alkyl substituted indole-imidazole and bromoalkane in the toluene solvent to synthesize the N-alkyl substituted indole-imidazolium salt compounds. The compounds have good anti-tumor cytotoxicity activity.

The invention discloses a series of isosorbide-monoimidazole salt compounds with a structural formula (as shown in a figure I or figure II) and a preparation method of the isosorbide-monoimidazole salt compounds. The preparation method includes: adopting isosorbide as a raw material, performing reaction with methylsulfonyl chloride under an anhydrous pyridine condition to obtain isosorbide methanesulfonate, subjecting to thermal reaction with 2-methylimidazole or 5,6-dimethyl benzimidazole in an anhydrous DMF (dimethyl formamide) solvent to synthesize isosorbide-monoimidazole, and performing reflux reaction with alkyl bromide in a methylbenzene solvent to synthesize the isosorbide-monoimidazole salt compounds. The isosorbide-monoimidazole salt compounds show great analgesic effects.