30 results about "Dimethylbenzimidazole" patented technology

The invention describes a nutraceutical composition and method for preventing / treating cancer or augmenting chemotherapy in advanced stage malignancies; comprised of [1] tumoricidal herbs; beth root, galbanum, gromwell root, wild yam, balm of gilead bud, frankincense, [2] an antiproliferative herb; speranskia [3] a natural lactic acid dehydrogenase (LDH) inhibitor, 2′,3,4′5,7-pentahydroxyflavone or cinnamon, [4] alkalizing agents: calcium, magnesium, potassium or bicarbonate salts, barley grass, chlorella and spirulina [5] at least one quinone and [6] at least one agent capable of maximizing oxidative mitochondrial function preferably riboflavin, 6,7-Dimethyl-8-(1-D-ribityl)lumazine, ribitol, 5,6-dimethylbenzimidazole, tetrahydrobiopterin and a pharmaceutically acceptable carrier.

The invention discloses a method for synthesizing 1-difluoromethyl imidazole and a derivative thereof. The method is characterized in that ethyl bromodifluoroacetate, a substrate iminazole and a derivative thereof and alkali are dissolved in a reaction solvent, the mixed liquid is heated and stirred, a difluoromethylation reaction happens, and the substrate is benzimidazole, 2-phenyl benzimidazole, 5-nitrobenzimidazole, 5,6-dimethyl benzimidazole, imidazole, 2-methylimidazole and 2-ethyl imidazole. Ethyl bromodifluoroacetate is adopted as a difluoromethylation reagent, no ozone is consumed, environmental friendliness is achieved, the whole reaction condition is mild and aftertreatment is simple.

The invention discloses a series of isomannide-bis-benzimidazole salt compounds having a structural general formula (as in figure 1) and a preparation method thereof; isomannide, as a raw material, and 4-toluene sulfonyl chloride are converted into isomannide p-toluenesulfonate under dichloromethane and anhydrous pyridine, the isomannide p-toluenesulfonate and benzimidazole or 5,6-dimethylbenzimidazole are subjected to thermal reaction in anhydrous DMF (dimethylformamide) solvent to synthesize isomannide-bis-benzimidazole, and on such basis, the isomannide-bis-benzimidazole and alkyl bromide are subjected to reflux reaction in acetonitrile solvent to synthesize isomannide-bis-benzimidazole salt compounds. Results of in-vitro antitumor active cytotoxicity test indicate that part of the compounds have good cytotoxicity.

The invention discloses a benzimidazole binuclear zinc metal complex and an application of the complex in a PVC (polyvinyl chloride) thermal stabilizer. The benzimidazole binuclear zinc metal complex Zn2L2(H2PO3)4 is prepared by the following steps: firstly, by using m-phthalic acid and 4, 5-dimethyl o-phenylenediamine as an initial raw material and polyphosphoric acid as a solvent and a catalyst, preparing a benzimidazole ligand 1, 3-di(2-(5, 6-dimehtyl benzimidazole)) benzene (ligand L); and preparing the complex by means of a simple solution method. By using the benzimidazole binuclear zinc metal complex Zn2L2(H2PO3)4 as a main raw material which is supplemented with other co-stabilizers to prepare a compound stabilizer, and the compound stabilizer is added into PVC to synergically improve the thermal stability of PVC. For 100 parts of PVC by weight, the additive amount of the complex is 0.2-3.5 parts by weight, preferably 0.5-1.5 parts by weight. The thermal stabilizer disclosed by the invention is convenient to prepare, can be used for improving the stainability of PVC and the long-term thermal stability, and has a good application prospect.

A composition can include a Rho zeolite with a RHO topology having a Si to B ratio or a Si to Al ratio greater than or equal to 8. Making such a composition can include heating an aqueous reaction mixture having a molar ratio of atomic Si to atomic B of about 4 to about 50 or a molar ratio of atomic Si to atomic Al of about 4 to about 50 in the presence of a C4-C6 diquat of N,2-dimethylbenzimidazole structure directing agent to a temperature of at least 75 deg C to produce a Rho zeolite.

The invention discloses a 11, 12-dimethyl benzimidazole-1, 8-naphthalimide-platinum complex and a preparation method and application thereof. The preparation method of the complex mainly comprises: putting compounds shown in the formulas (II) and (III) into an organic solvent, and performing a coordination reaction process under heating or no heating to obtain a desired product. Compared with thecommon antitumor drug cisplatin, the complex has higher inhibitory activity to some cancer cells and lower toxicity to human liver normal cells HL-7702. The structure of the complex is shown in the formula (I). The raw materials for preparation of the complex are shown in the formulas (II) and (III).

The invention discloses a series of N-alkyl substituted indole-imidazolium salt compounds having a structural formula (represented b figure I), and a preparation method thereof. The preparation method comprises the following steps: synthesizing N-alkyl substituted indole from indole used as a raw material and dibromoalkane in an anhydrous DMF solvent, carrying out a heating reaction on the N-alkyl substituted indole and 5,6-dimethylbenzimidazole in a toluene solvent to synthesize N-alkyl substituted indole-imidazole, and carrying out a refluxing reaction on the N-alkyl substituted indole-imidazole and bromoalkane in the toluene solvent to synthesize the N-alkyl substituted indole-imidazolium salt compounds. The compounds have good anti-tumor cytotoxicity activity.

The present invention provides a pyrenylbenzimidazole fluorescent probe and its preparation method and application. The fluorescent probe has the structure shown in formula (I), and its preparation process is as follows: (1) 1, 2-di Tolylbenzimidazole and (3-bromopropyl) dimethyl ammonium bromide are added to acetonitrile, and heated to reflux, after the reaction is completed, compound A is isolated; (2) compound A and 1-pyrene formaldehyde are Heating to reflux in ethanol, after separation and purification, the fluorescent probe with the structure shown in formula (I) was obtained. The fluorescent probe of the invention can be used for the detection of heparin, and has the characteristics of simple synthesis, good water solubility, long luminescent wavelength, high sensitivity to heparin, strong selectivity, dual-mode response and wide application range.

The invention discloses a series of isosorbide-monoimidazole salt compounds with a structural formula (as shown in a figure I or figure II) and a preparation method of the isosorbide-monoimidazole salt compounds. The preparation method includes: adopting isosorbide as a raw material, performing reaction with methylsulfonyl chloride under an anhydrous pyridine condition to obtain isosorbide methanesulfonate, subjecting to thermal reaction with 2-methylimidazole or 5,6-dimethyl benzimidazole in an anhydrous DMF (dimethyl formamide) solvent to synthesize isosorbide-monoimidazole, and performing reflux reaction with alkyl bromide in a methylbenzene solvent to synthesize the isosorbide-monoimidazole salt compounds. The isosorbide-monoimidazole salt compounds show great analgesic effects.

The invention discloses a preparation method and application of biphenyl bridged bisbenzimidazolium. Using 1,3-dimethylbenzimidazolium iodide and 1,4-diiodobiphenyl as substrates, metal salts as catalysts, and bases as additives, react at 0-200°C for 0.1-96 hours, One-step biphenyl bridged bis-benzimidazolium. Dissolve the compound in acetonitrile, inject a small amount of the resulting solution between two pieces of ITO glass, apply a voltage, the solution changes from colorless to brown, remove the voltage, and the solution becomes colorless again, this discoloration process is reversible and can be repeated repeatedly. The invention has the advantages of simple process, convenient operation, low cost, environmental friendliness, good repeatability, etc., and is expected to realize industrialized large-scale production; the invention synthesizes an imidazolium derivative with electrochromic properties, which is expected to be applied to electronic Display, color-changing glass, automotive anti-glare rearview mirror and other fields.