4 results about "Dimethylbenzimidazole" patented technology

The invention discloses preparation and application of a dye-sensitized photocatalyst based on metal polyphthalocyanine, and relates to the technical field of photocatalytic materials and new energy. Titanium dioxide (P25) serves as a carrier, metal polyphthalocyanine (MPPc) is loaded on the surface of the carrier through an in-situ polymerization method, a terpyridyl ruthenium complex (RuP) is further adsorbed to serve as a photosensitizer, and the ternary composite photocatalyst (RuP-P25-MPPc) is constructed. The catalyst can efficiently catalyze carbon dioxide to be reduced into carbon monoxide by taking N, N-dimethylformamide (DMF) as a solvent, 1, 3-dimethylbenzimidazole (BIH) as a sacrificial agent and phenol as a proton source under the irradiation of visible light. The introduction of metal polyphthalocyanine effectively improves the charge separation efficiency and provides abundant catalytic sites, the performance of the catalyst taking iron polyphthalocyanine (FePPc) as a base is optimal, and the CO generation rate can reach 207 [mu] mol g <-1 > h <-1 >. The catalyst is clear in structure, simple and convenient in preparation method and suitable for the field of solar-driven carbon dioxide resource utilization.

This invention belongs to the field of biomedical technology, specifically relating to the application of 5,6-dimethylbenzimidazole in the preparation of drugs for treating colorectal cancer. Through this invention, it was found that 5,6-dimethylbenzimidazole can significantly inhibit the proliferation, colony formation, and migration of colorectal cancer cells in a concentration-dependent manner. In an in vivo tumor-bearing model, it inhibits tumor growth and reduces the expression of the proliferation marker Ki-67, and shows no significant organ toxicity to the liver, spleen, and kidneys of mice, indicating that 5,6-dimethylbenzimidazole has good safety. Furthermore, its specific mechanism of action was explored in depth. 5,6-dimethylbenzimidazole may exert its anti-tumor effect by regulating the HMOX1 / GPX4 related pathway, upregulating HMOX1 and downregulating GPX4, promoting ferroptosis in colorectal cancer cells and transplanted tumors.

The invention belongs to the technical field of probes, and particularly relates to a fluorescence and mass spectrum double-sensibilization labeled probe as well as a preparation method and application thereof. The probe takes benzimidazole as a mother ring and carbohydrazide as a reaction group, and comprises a probe 1 and a probe 2, the probe 1 is iodinated 4-(1, 3-dimethyl-benzimidazole-2-yl) benzoyl hydrazine d0, the chemical structural formula of the probe 1 is shown in the specification, and X is H; the probe 1 is deuterated iodinated 4-(1, 3-dimethyl-benzimidazole-2-yl) benzoyl hydrazine d6, the probe 2 is deuterated iodinated 4-(1, 3-dimethyl-benzimidazole-2-yl) benzoyl hydrazine d6, the chemical structural formula is shown in the specification, and X is D. The method disclosed by the invention can be used for rapidly, accurately and sensitively labeling and detecting the active carbonyl compound, is particularly suitable for separation and detection of trace and trace micromolecular active carbonyl compounds in a complex system, can be used for fluorescence labeling and analysis of various fatty aldehydes in the research fields of life analysis, food analysis and the like, and has a wide application prospect.

This invention belongs to the field of rare earth-transition complex preparation technology, and discloses a pentanuclear rare earth-transition heterometallic complex, its preparation method, and its applications. The preparation method provided by this invention is as follows: Dy(CF3SO3)3, NiCl2·6H2O, and ligand H2L (1,2-di(1-methyl-1H-benzo[d]imidazol-2-yl)ethane-1,2-diol) are mixed and dissolved in CH3OH and H2O in a certain proportion. Then, Et3N and NaN3 are added. The mixed solution is stirred at 80°C, allowed to stand and evaporate, and the reaction is completed to obtain blue blocky crystals. This pentanuclear rare earth-transition heterometallic complex has a bow-tie-shaped metallic framework structure and can be applied to the preparation of molecular magnetic materials and molecular memory materials.