61 results about "Injectable Suspension" patented technology

The present invention relates to microspheres useful for embolization which comprises polyvinylalcohol. The present invention also relates to an injectable suspension suitable for embolization which comprises the polyvinylalcohol microspheres and a suitable liquid carrier. The present invention further relates to a method for prophylactic or therapeutic embolization which comprises administering to a mammal an injectable suspension containing the polyvinylalcohol microspheres and a suitable liquid carrier. Finally, the present, invention relates to a process for producing the polyvinylalcbhol microspheres.

A composition comprising an alloplastic injectable suspension for use as a dermal filler comprising a biocompatible and pliable material and a physiologically acceptable suspending agent is provided. A method of making a composition comprising an alloplastic injectable suspension for use as a dermal filler comprising a biocompatible and pliable material and a physiologically acceptable suspending agent, said method comprising admixing a biocompatible and pliable material with a physiologically acceptable suspending agent, is also provided. A method of augmenting soft tissue to provide long-term reduction of a skin defect, said method comprising stimulating collagen beneath the skin defect is further provided. In an embodiment of the method of augmenting soft tissue, the stimulation of collagen production is effected by injecting into the deep reticular dermis an a dermal filler, said dermal filler being an alloplastic injectable suspension and comprising a biocompatible and pliable material and a physiologically acceptable suspending agent.

The present invention provides formulations useful for treating infections, in particular, formulations that include the active pharmaceutical ingredient Posaconazole in an injectable suspension of particles that is stable when subjected to terminal sterilization. Preferred median particle sizes of between 1.5 and 3.0 microns are found to result in superior pharmacokinetic characteristics, such as those displayed below.

Absorbable particles which comprises poly-4-hydroxybutyrate and/or its copolymers are formulated in injectable suspension suitable for prophylactic or therapeutic embolization, which comprises administering to a human or animal the injectable suspension process for producing particles of the poly-4-hydroxybutyrate and/or its copolymer.

The present invention provides formulations useful for treating infections, in particular, formulations that include the active pharmaceutical ingredient posaconazole in an injectable suspension that is stable when subjected to terminal steam sterilization.

A composition comprising an alloplastic injectable suspension for use as a dermal filler comprising a biocompatible and pliable material and a physiologically acceptable suspending agent is provided. A method of making a composition comprising an alloplastic injectable suspension for use as a dermal filler comprising a biocompatible and pliable material and a physiologically acceptable suspending agent, said method comprising admixing a biocompatible and pliable material with a physiologically acceptable suspending agent, is also provided. A method of augmenting soft tissue to provide long-term reduction of a skin defect, said method comprising stimulating collagen beneath the skin defect is further provided. In an embodiment of the method of augmenting soft tissue, the stimulation of collagen production is effected by injecting into the deep reticular dermis an a dermal filler, said dermal filler being an alloplastic injectable suspension and comprising a biocompatible and pliable material and a physiologically acceptable suspending agent.

Disclosed are injectable suspensions of gas filled microbubbles in an aqueous carrier liquid usable as contrast agents in ultrasonic echography. The suspensions comprise amphipathic compounds of which at least one may be a laminarized phospholipid as a stabiliser of the microbubbles against collapse with time and pressure. The concentration of phospholipids in the carrier liquid is below 0.01% wt but is at least equal to or above that at which phospholipid molecules are present solely at the gas microbubble-liquid interface. Also disclosed are methods of preparation of the stable suspensions of gas filled microbubbles, as well as dry formulations which, upon reconstitution in an aqueous carrier liquid, will form the injectable suspensions of gas filled microbubbles of the invention and methods of making and using the same The preferred dry formulations are stable when stored over time and at temperatures above ambient temperature and further comprise a lipid acid preserving agent additive.

The invention discloses netilmicin sulfate lyophiled powder injection and a preparation method of the netilmicin sulfate lyophiled powder injection. Netilmicin sulfate and additives are added with water to be prepared into netilmicin sulfate injectable suspension, and the netilmicin sulfate lyophiled powder injection is obtained through freeze drying, wherein the additives are inclusion moleculesand pH conditioning agents, the inclusion molecules are selected from bletilla striata polysaccharide, beta-cyclodextrin, urea, thiourea, beta-cyclodextrin derivatives, deoxycholic acid and starch, and the pH conditioning agents are selected from sodium carbonate, sodium bicarbonate, ammonia water, sulfuric acid and phosphoric acid. Required auxiliary materials are few, the preparation process issimple, the freeze drying process is particularly screened and optimized, and the netilmicin sulfate lyophiled powder injection and the preparation method has the characteristics that the stability is high, the biological availability is high, the production cost is low, the quality is safe and reliable, and the like.

The invention relates to a nano-micro structure silibinin drug composite powder and a preparation method thereof. The silibinin drug is dissolved into an organic solvent which is mutually soluble with the water, the mixture is added into a water solution containing water-solubility pharmaceutical excipients to obtain nano silibinin drug particle injectable suspension, the injectable suspension is atomized and dried to obtain the nano-micro structure silibinin drug composite powder. The composite powder has good redispersibility and is dispersed in the water to obtain the uniform injectable suspension with the grain diameter of the drug being less than 1000 nm. The method has simple operation, low cost and promising industrialized production prospect. The powder has fast dissolution rate and high biological utilization rate, and can be used for preparing tablet, capsule, granules or suspensions.

This invention relates to pharmaceutical compositions for veterinary use in form of aqueous injectable suspensions comprising Florfenicol or Florfenicol in form of a substantially water-insoluble complex, co-crystal or salt, sterile and micronised, in a concentration up to 500 mg/ml. The suspensions enable parenteral antimicrobial therapies in animals, with limited numbers of injections and showing good general- and local tolerances. They also possess a limited sedimentation on standing as well as after shipping, are easily resuspendable and have good syringiblity.

The invention relates to a compound preparation for treating diseases caused by poultry sensitive bacteria and a preparation method thereof. The compound preparation is a long-acting injectable suspension prepared from florfenicol and occrycetin as main medicines and comprises 2.0-20.0% (W/V) of florfenicol, 5.0-30.0% (W/V) of occrycetin, 0.05-0.40% (W/V) of antioxidant, 1-10% (W/V) of antiallergic factor synergist, 0.01-0.04% (W/V) of complexing agent, 0.01-15% (W/V) of suspending agent, 1.0-10.0% (W/V) of flocculating agent, 0.01-0.5% (W/V) of preservative and 60-100% (W/V) of water for injection. The liquid medicine of the invention has stable performance and can effectively overcome the defects of instable performance, easy color change, precipitation and failure and the like of injections. The compound preparation has small irritativeness, low cost and simple process and can prolong the residence time of medicine in body and increase the bioavailability of the medicine. The compound preparation can be used for preventing and treating infectious diseases caused by poultry sensitive bacteria, such as pasteurellosis, colibacillosis, salmonellosis, contagious pleuropneumonia, mycoplasmlpneumonia of swine, acute respiratory infection and the like.

The invention discloses a preparation method of a calamine lotion, and the product belongs to the field of pharmacy. The calamine lotion is the over the counter drug of dermatological pharmacy, is the light pink injectable suspension in appearance, is precipitated after being placed, but is the uniform injectable suspension after being shaken out. Calamine and zinc oxide which are contained in the product have the constriction and protection effects, and also have weaker antiseptic function, so the calamine lotion can be applied in acute pruritus skin diseases and various rashes, such as urticaria, prickly heat, eczema and the like. The product is produced from the raw materials of: calamine powder, zinc oxide powder, glycerol, polysorbate, bromogeramine and distilled water. The calamine lotion which is prepared by the method is fine, has low layered sedimentation velocity, is not easy to block after long-term storage, and is the calamine lotion with good quality.

The invention discloses a preparation method and application of magnetically loaded ionic liquid microsphere immobilized cells. The preparation method comprises the following steps of: mixing sodium alginate, a Fe3O4/CS magnetic material and 1-butyl-3-methylimidazolium hexafluorophosphate to obtain a mixed solution; mixing the mixed solution with cell suspension to obtain injectable suspension; and immobilizing the injectable suspension by using CaCl2 as a crosslinking agent to obtain the magnetically loaded ionic liquid microsphere immobilized cells. As the immobilized cells prepared by the method have the magnetism, the separation and continuous fermentation of immobilized cells are facilitated, and ionic liquid loaded on a magnetic material greatly improves the catalytic activity of theimmobilized cells.

The invention relates to a high-concentration injectable suspension combination containing doxycycline and florfenicol and a preparation process thereof. The suspension combination comprises the following components: 4.0 % to 30.0% (W/V) of florfenicol, 4.0 % to 30.0% (W/V) of doxycycline, 0.05% to 0.40% (W/V) of anti-oxidant, 0.01% to 0.04 % (W/V) of complexing agent, 0.01% to 15% (W/V) of suspending agent, 1.0% to 10.0% (W/V) of flocculating agent, 0.01% to 0.5% (W/V) of antiseptic agent and 60% to 100% of water for injection. The invention has the advantages that the component content of the drug is high, the administration volume is small, animal suffers less pain and irritation, adverse reactions, safety accidents and the like caused by the organic solvent are reduced, the preparation cost is low and the preparation is simple. The invention is applicable in preventing and treating the mixed bacterial infection diseases of domestic animals and the like.

The invention discloses a crystal separating drug sustained-release microspherule comprising the following components in parts by weight: 4-9 parts of water-insoluble drug, 0.1-2 parts of sustained-release polymer and 1-4 parts of microspherule bridging agent. In addition, the invention also discloses a preparation method of the crystal separating drug sustained-release microspherule, comprising the following steps: 1) dissolving water-insoluble drug into good solvent to form drug solution; 2) adding the drug solution into the opposite phase solvent of the drug, and stirring; 3) after the injectable suspension of drug microcrystal in the opposite phase solvent is completely formed and stabilized, adding solution containing the sustained-release polymer, the microspherule bridging agent and the solvent, and stirring; and 4) after the drug microspherule is completely formed and the solvent for dissolving the sustained-release polymer and the microspherule bridging agent is completely volatilized, stopping stirring, and filtering and drying the drug microspherule. The method can obtain the granule diameter with wider range, more regular and smooth surface and more controllable inner and outer releasing rate of drug.

The invention provides sea cucumber rose liquor and a preparation method thereof. The preparation method is characterized by comprising the following steps: taking high-quality food wine as substrate, matching with injectable suspension of sea cucumber and rose, and then carrying out the process steps of soaking, emulsifying and homogenizing, high-precision filtering, seasoning, encapsulating and the like. The sea cucumber rose liquor comprises the following components by weight percent: 70-90% of food wine and 15-35% of injectable suspension of sea cucumber and rose. In the invention, the compatibility of raw material components of the sea cucumber and rose is scientific, namely, the outer part can be nourished by the inner part, just like double swords in combination; and the liquor can relieve fatigue, strengthen human immunity and build the body after being drunk in a proper amount for a long time.