Injectable pharmaceutical suspension comprising posaconazole
A technology of posaconazole and medicine, applied in the field of preparations for treating infection, can solve the problems such as undisclosed posaconazole suspension for injection
Inactive Publication Date: 2007-06-27
SCHERING AG
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- Summary
- Abstract
- Description
- Claims
- Application Information
AI Technical Summary
Problems solved by technology
[0006] However, none of the above references discloses a posaconazole injectable suspension that remains stable through terminal steam sterilization and throughout the shelf life of the product.
Method used
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Embodiment 1
[0220] Element
[0221] Note: In Example 1 the pH is 7.4.
Embodiment 2
[0223] Element
[0224] Note: In Example 2 the pH is 6.4.
Embodiment 3
[0226] Element
[0227] ammonium sulfate
[0228] Note: In Example 3 the pH was 6.6.
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Abstract
The present invention provides formulations useful for treating infections, in particular, formulations that include the active pharmaceutical ingredient posaconazole in an injectable suspension that is stable when subjected to terminal steam sterilization.
Description
field of invention [0001] The present invention relates to formulations for the treatment of infections. In particular, these formulations include injectable suspensions of the active pharmaceutical ingredient posaconazole which are stable upon terminal steam sterilization and throughout the shelf life of the product. Background of the invention [0002] Posaconazole is an antifungal drug represented by the following chemical structure: [0003] [0004] It has been developed as an oral suspension (40 mg / ml) by Schering Corporation, Kenilworth, NJ. under the trade name NOXAFIL(R), see for example US Patent Nos. 5,703,079, 5,661,151, WO 02 / 80678 published October 17, 2002 and EP 1 372 394 published January 2, 2004. Additionally, other formulations of posaconazole have been disclosed. Solid formulations (capsules / tablets) of posaconazole are disclosed in US Patent Nos. 5,972,381 and 5,834,472. Finally, topical forms of posaconazole such as lotions, creams, ointments or ...
Claims
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IPC IPC(8): A61K9/10A61K31/496A61P33/00A61P31/10A61K47/02A61K47/24A61K47/26
CPCA61K47/26A61K47/24A61K47/02A61P31/10A61P33/00A61P43/00A61K31/496
Inventor L·维奇-拉科什马南S·乌格伍V·桑德维斯C·赫达洛R·S·哈尔G·克里希纳Z·王M·塔格列提
Owner SCHERING AG
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