Compound preparation for treating diseases caused by poultry sensitive bacteria and preparation method thereof

A technology of compound preparations and sensitive bacteria, which is applied in the field of long-acting injectable compound suspensions and preparations, can solve the problems of failure, precipitation, easy discoloration, etc., and achieve the effect of long-term action, small irritation, and stable liquid medicine

Inactive Publication Date: 2011-03-23
TIANJIN RINGPU BIO TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] In addition, oxytetracycline hydrochloride and florfenicol currently sold in the market are mostly unilateral injections, and there is no long-acting suspension product, and oxytetracycline hydrochloride injection has unstable performance, easy discoloration, precipitation, failure, and is made into The properties of the suspension will change significantly, and

Method used

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  • Compound preparation for treating diseases caused by poultry sensitive bacteria and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] components

[0038] Oxytetracycline Hydrochloride 20g

[0039] Florfenicol 5g

[0040] Anhydrous sodium sulfite 0.4g

[0041] Disodium edetate 0.03g

[0042] Polyvinylpyrrolidone 0.50g

[0043] Sodium carboxymethylcellulose 0.3g

[0044] Indomethacin Sodium 2g

[0045] Tween-80 0.35g

[0046] Sodium citrate 5.0g

[0047] Methylparaben 0.05g

[0048] Add water for injection to 100ml

[0049] The preparation process is:

[0050] (1) Dissolve disodium edetate, sodium citrate and anhydrous sodium sulfite in sequence in 20 ml of water for injection, and filter with a 0.45 μm microporous membrane to obtain solution A.

[0051] (2) Take 10ml of water for injection, add methylparaben, heat to dissolve and cool to room temperature, then add 50ml of water for injection, dissolve carboxymethylcellulose sodium and indomethacin sodium, and then add polyvinylpyrrolidone and Tween-80, stirred evenly, and filtered with a 0.45 μm microporous membrane to obtain solution B.

...

Embodiment 2

[0056] components

[0057] Oxytetracycline Hydrochloride 30g

[0058] Florfenicol 10g

[0059] Anhydrous sodium sulfite 0.5g

[0060]Sodium formaldehyde sulfoxylate 0.35g

[0061] Disodium edetate 0.04g

[0062] Sodium citrate 4.0g

[0063] Polyvinylpyrrolidone 0.55g

[0064] Sodium carboxymethylcellulose 0.5g

[0065] Indomethacin Sodium 3g

[0066] Potassium dihydrogen phosphate 2.2g

[0067] Methylparaben 0.03g

[0068] Ethylparaben 0.03g

[0069] Add water for injection to 100ml

[0070] The preparation process is:

[0071] (1) Dissolve disodium edetate, sodium citrate, potassium dihydrogen phosphate, sodium formaldehyde sulfoxylate and anhydrous sodium sulfite in sequence in 20ml of water for injection, and filter with a 0.45 μm microporous membrane to obtain Solution A.

[0072] (2) Take 10ml of water for injection, add methylparaben and ethylparaben, heat to dissolve and cool to room temperature, then add 50ml of water for injection, dissolve sodium carboxy...

Embodiment 3

[0076] Embodiment 3: Drug susceptibility test proves the antibacterial effect of oxytetracycline hydrochloride and florfenicol combined application:

[0077] Drug susceptibility test report

[0078]

[0079] Note: 0 is not sensitive; low sensitivity ≤ 10mm; moderate sensitivity 10-14mm; high sensitivity 15-20mm; extreme sensitivity ≥ 20mm. *** is very clear; * is very unclear

[0080] The above test data show that the composition of the present invention has a good additive effect and antibacterial effect, so it is proved that the combination of the two has a synergistic effect.

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Abstract

The invention relates to a compound preparation for treating diseases caused by poultry sensitive bacteria and a preparation method thereof. The compound preparation is a long-acting injectable suspension prepared from florfenicol and occrycetin as main medicines and comprises 2.0-20.0% (W/V) of florfenicol, 5.0-30.0% (W/V) of occrycetin, 0.05-0.40% (W/V) of antioxidant, 1-10% (W/V) of antiallergic factor synergist, 0.01-0.04% (W/V) of complexing agent, 0.01-15% (W/V) of suspending agent, 1.0-10.0% (W/V) of flocculating agent, 0.01-0.5% (W/V) of preservative and 60-100% (W/V) of water for injection. The liquid medicine of the invention has stable performance and can effectively overcome the defects of instable performance, easy color change, precipitation and failure and the like of injections. The compound preparation has small irritativeness, low cost and simple process and can prolong the residence time of medicine in body and increase the bioavailability of the medicine. The compound preparation can be used for preventing and treating infectious diseases caused by poultry sensitive bacteria, such as pasteurellosis, colibacillosis, salmonellosis, contagious pleuropneumonia, mycoplasmlpneumonia of swine, acute respiratory infection and the like.

Description

technical field [0001] The invention belongs to the technical field of veterinary medicine, and in particular relates to a long-acting injectable compound suspension for treating diseases caused by sensitive bacteria in livestock and poultry and a preparation method thereof. The compound preparation is used for preventing and treating diseases caused by sensitive bacteria in livestock and poultry. Infections such as pasteurellosis, colibacillosis and salmonellosis, contagious pleuropneumonia, swine panting, acute respiratory infections, etc. Background technique [0002] At present, with the long-term use of antibiotics, livestock and poultry are facing a huge threat of drug resistance, and the drug resistance of pathogenic bacteria is increasing year by year, resulting in a decline in curative effect and an increase in dosage. Clinically, it often manifests as a complicated condition and multiple mixed infections. Therefore, the development of safe, high-efficiency, and br...

Claims

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Application Information

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IPC IPC(8): A61K31/65A61K31/165A61K9/10A61P31/04
CPCY02A40/70
Inventor 马丽伟
Owner TIANJIN RINGPU BIO TECH
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