15 results about "Skin Fillers" patented technology

Introduced here are novel techniques and tools for augmenting the lips through superficial linear injection of dermal fillers. At a high level, these techniques are representative of a two-step approach to augmentation. In the first stage, an implement that is appropriately positioned inside a lip can be moved sideways—an action referred to as a “side push.” In the second stage, dermal filler can be ejected from the implement so as to fill the resulting void. These techniques can be used by healthcare professionals to reshape the lips for medical or aesthetic purposes. These techniques were developed in an attempt to permit augmentation of the outer surface of a lip so as to increase its volume by expanding sideways while turning the lip outward. Presented here are also tools to improve the accuracy of injection. With these techniques, the desired result-namely, a plumper lip—may be readily and consistently achievable.

A method for filtering or removing agglomerates of individual particles from a viscous substance, such as a dermal filler formulation, is provided. The method involves loading the viscous substance into an extrusion system with a sieve or filter located inside, outside, or adjacent to the system, or external thereto. The substance is extruded through the filter / sieve, which filters / removes agglomerates present in the viscous substance due to their larger size. Alternatively, pressure-based filtration causes the separation of individual particles, which causes the agglomerates to break down, allowing the viscous substance to pass through the extrusion system without clogging issues. The filtered viscous substance is suitable for administration to a patient. The present invention also describes a device for implementing the proposed pressure-based filtration technique.

The application provides a skin filler in-vivo detection device and method, relates to the technical field of skin and subcutaneous tissue detection, and comprises a light source and a spectrometer module, a probe area, the light source and the spectrometer module are used for providing OCT broadband interference light and Raman excitation light, and receiving and processing OCT interference signals and Raman scattering signals; the probe area is integrated, and the probe area is provided with optical beam combining and separating elements, a two-dimensional scanning galvanometer and a scanning lens; the application breaks through the limitation of traditional evaluation means, realizes real-time monitoring in situ in the human body, adopts full-optical non-invasive design, the probe can be directly attached to the human skin, through coaxial dual-mode light paths, long-period longitudinal follow-up of the same part of the human body is carried out under the premise of non-invasion and non-radiation, the most real in-vivo metabolism data of the human body is acquired, and the problems that the traditional animal model data is greatly different from the human body and the human face cannot be destructively biopsied are solved.

The present disclosure relates to a cross-linked HA-collagen hydrogel as a skin filler, in particular to a cross-linked macromolecular matrix comprising: lysine; hyaluronic acid; and collagen; wherein the hyaluronic acid is crosslinked with the collagen via at least one endogenous amino group on the collagen and / or via at least one amino group present on the lysine.

The present invention provides a skin filler and a method for treating wrinkles in a patient's skin. [Solution] A polymer matrix is ​​provided which contains lysine, hyaluronic acid, and collagen, wherein the hyaluronic acid and collagen form a hydrogel, and the polymer matrix does not contain chitosan.

Provided herein are dermal fillers including decellularized plant or fungal tissue from which cellular materials and nucleic acids of the tissue are removed; as well as methods and uses thereof for cosmetic and / or reconstructive applications. Also provided are methods for preparing such dermal fillers, and dermal filler kits.

A process is provided for manufacturing injectable hyaluronic acid (HA) dermal fillers consisting of cross-linking high molecular weight (MW) HA with the cross-linking agent 1,4-butanediol diglycidyl ether (BDDE) with a relatively small amount of BDDE by reaction in a planetary centrifuge under vacuum or with a relatively large amount of BDDE with mechanical agitation for the reaction and an ultra-turrax device for particle sizing. The processes generate HA hydrogels with only one degree of cross-linking for use in manufacturing HA dermal fillers with varying concentrations of HA and combinations of particle sizes. HA dermal fillers are based on particle balance technology (PBT), in which hydrogels with different physico-chemical and rheological properties are obtained. They can be used in medical surgery and orthopaedic applications, as well as for dermal filling, body and facial contouring, volumisation and skin hydration.

The present invention relates to a PLA microparticle composition for a dermal filler and a production method therefor. Provided are a PLA microparticle composition for a dermal filler, the composition being uniformly produced through micro-spraying by a chemical-resistant spray equipped with a brass nozzle, and a production method for PLA microparticles for a dermal filler, the method exhibiting a high yield, and thus same may be utilized in the skin plastic surgery filler production industry by having a cheaper and simpler production process.

This invention relates to an injectable dermal filler formulation for providing improved and uniform plumping and filling effects. Specifically, the formulation comprises a combination of hyaluronic acid and polyorthoesters and can be used for cosmetic purposes.

The invention discloses an anti-skinning filler type polymercaptan epoxy adhesive and a preparation method thereof, sheet or layered filler is added into a curing agent and is directionally arranged on the surface layer of the adhesive to form a compact labyrinth type barrier layer, so that permeation of water vapor in air into the adhesive is effectively delayed; the hydrophobic filler is low in surface energy, so that the interaction between the adhesive surface layer and polar substances (such as water and oxygen) in air is reduced, and the curing reaction rate of the surface layer area is slowed down relative to the interior; the filler has good compatibility with a polythiol system, has anti-skinning protection, does not influence the curing effect on epoxy resin components, and has good application effect.

The invention discloses a preparation method of a polylactic acid skin filler. The preparation method comprises the following steps: S1, putting polylactic acid microspheres and auxiliary materials into a material tank, and mixing; s2, mixing and stirring the material tank filled with the raw materials by adopting a planetary stirrer; and S3, connecting the material tank to a filling machine for sub-packaging to obtain the polylactic acid skin filler. And S4, performing freeze drying, capping and irradiation sterilization on the sub-packaged product to obtain the finished product of the filling agent. According to the preparation method of the polylactic acid skin filler, the polylactic acid skin filler is prepared by adopting planetary stirring, a stirring paddle is not needed, and no stirring dead angle exists; and a feed liquid transfer link is eliminated in the production process, so that the production efficiency and the sanitary safety are further improved.

Provided herein are systems and methods for delivering to the tissue site a dermal filler formulation comprising a hydrogel that anneals in vivo to form a porous covalently stabilized scaffold under conditions sufficient to form a cell matrix within the porous covalently stabilized scaffold effective to permanently fill at least part of a tissue site of a subject with the cell matrix while minimizing a foreign body response in the subject.

The invention relates to a facial skin filler and a preparation method thereof. The method comprises the following steps: S1-a: dissolving collagen in water, then adding hydroxyapatite microspheres, and mixing to obtain a first mixture; s1-b: adding the first mixture and an emulsifier into the oil phase, keeping the temperature constant, then stirring to obtain a second mixture, and then carrying out solid-liquid separation to obtain intermediate microspheres; s1-c: adding the intermediate microspheres into a cross-linking agent solution for cross-linking to obtain a third mixture, and then performing solid-liquid centrifugal separation to obtain composite microspheres; s2, dissolving first sodium hyaluronate with the molecular weight of 120-150 million Daltons and second sodium hyaluronate with the molecular weight of 20-40 million Daltons in water to obtain a sodium hyaluronate aqueous solution; s3, mixing the composite microspheres with a sodium hyaluronate aqueous solution to obtain the facial skin filling agent. The facial skin filler has improved biocompatibility, prolonged retention time, and improved injection performance.

An apparatus can aid usage of a plunger, for example helping a medical practitioner use a hypodermic syringe to inject dermal filler. The apparatus can fasten a thumb rest of a plunger of the syringe to a thumb of the practitioner and can support one-handed operation of the syringe. With the plunger so fastened, reverse thumb motion can retract the plunger for aspiration, and forward thumb motion can advance the plunger for injection. The apparatus can comprise a member extending at least partially around the practitioner's thumb. The member can comprise an aperture configured to retain the thumb rest between the thumb and the member, with a shaft of the plunger passing through the aperture.

The invention belongs to the technical field of skin fillers, and particularly relates to a hydroxyapatite skin filler as well as a preparation method and application thereof. The hydroxyapatite skin filler is prepared from the following raw materials in percentage by mass: 3-4% of sodium carboxymethyl cellulose; 8%-10% of hydroxyapatite; 0.3% to 0.4% of lidocaine hydrochloride; 3%-4% of glycerin; the balance of the buffer solution is 100%; the buffer solution contains free hydrogen phosphate ions and free sodium ions; the concentration of the hydrogen phosphate ions in the buffer solution is 0.01 mol / L to 0.02 mol / L; the concentration of the sodium ions in the buffer solution is 0.01 mol / L to 0.04 mol / L. The hydroxyapatite skin filler can eliminate the side effects of red, swollen and painful, and also has the advantages of quick response and long filling time.