Dex-ibuprofen injectable suspension and preparation method thereof

A technology of suspension and preparation, applied in the field of dextro-ibuprofen suspension and preparation thereof, achieves the effects of beautiful appearance, low viscosity and fast absorption

Inactive Publication Date: 2012-05-02
陆荣政
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

The study of the dextrobuprofen suspension provided by the present invention has not yet seen relevant reports both at home and abroad

Method used

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  • Dex-ibuprofen injectable suspension and preparation method thereof
  • Dex-ibuprofen injectable suspension and preparation method thereof
  • Dex-ibuprofen injectable suspension and preparation method thereof

Examples

Experimental program
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Embodiment

[0024] prescription:

[0025]

[0026] Preparation process: (1) Mix 3g of low-acyl gellan gum, 4g of carrageenan and 2g of pectin evenly, add 1.5L of water, stir at 90-100°C for 20min to form a clear solution; (2) add 8g of potassium chloride , stirred for 5min to dissolve; (3) dexibuprofen 200g, after stirring evenly, add the remaining prescription amount of water and stir evenly.

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Abstract

The invention discloses a dex-ibuprofen injectable suspension and a preparation method thereof. The preparation consists of dex-ibuprofen, low-acyl gellan gum, carrageenan, pectin and a colloidal property reinforcing agent. The dex-ibuprofen injectable suspension prepared with the method is a thixotropic liquid, and has the characteristics of low viscosity, high suspension supporting property and permanent lamination resistance, so that the sizes of dex-ibuprofen particles can be kept stable during long-term storage.

Description

technical field [0001] The invention belongs to the field of pharmaceutical manufacturing, and relates to a prescription of a dosage form of ibuprofen, in particular to a suspension of ibuprofen and a preparation method thereof. Background technique [0002] Dexibuprofen, the chemical name is (2s)-2-[4-(2-methylpropyl)phenyl]ropionic acid(S)-2-(+)-(4-isobutylphenyl)propyl Acid, which is the S-(+)-isomer of ibuprofen (racemate), a widely used non-steroidal anti-inflammatory drug. [0003] The structural formula is: [0004] [0005] Ibuprofen, a derivative of phenylpropionic acid, is a safe and effective drug among traditional NSAIDs, and it is the first drug recommended in the pain ladder. Non-steroidal anti-inflammatory drugs (NSAIDs) have antipyretic and analgesic effects and are widely used in clinical practice. Dexibuprofen and ibuprofen have the same effect and use, but dexibuprofen is obviously superior to ibuprofen in terms of safety and pharmacokinetic properti...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/10A61K31/192A61K47/36A61P29/00
Inventor 陆荣政徐卓业文意芬
Owner 陆荣政
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