3 results about "Dexibuprofen" patented technology

The invention relates to a crystal form compound of dexibuprofen arginine, which has diffraction peaks at diffraction angles 2 theta of 6.0 + / -0.2 degrees, 16.8 + / -0.2 degrees, 17.9 + / -0.2 degrees, 19.1 + / -0.2 degrees, 21.5 + / -0.2 degrees, 23.4 + / -0.2 degrees and 24.1 + / -0.2 degrees in an X-ray powder diffraction pattern measured under Cu-K alpha radiation. The invention also relates to a preparation method of the crystal-form compound and a pharmaceutical composition containing the crystal-form compound.

The invention relates to a dexibuprofen true solution as well as a preparation method and application thereof. Specifically, the invention relates to a dexibuprofen true solution oral drop, which is prepared from 5 mg to 400 mg / ml of dexibuprofen and a cosolvent, the weight ratio of the dexibuprofen to the cosolvent is about 1.5: 1. Optionally, the dexibuprofen solution is subpackaged in a single-dose or multi-dose package. The prescription is the optimal prescription determined on the basis of a large number of optimized prescriptions, the design is reasonable, and the process is suitable for industrial production. The product is controllable in quality and stable in performance.

The present disclosure provides novel methods for treatment of patients with autophagy diseases by administering a prodrug of dexibuprofen, such as but not limited to dexibuprofen dimethylamino ethyl ester (mDex) or a pharmaceutically acceptable salt thereof and compositions comprising the same.