91results about How to "Through high" patented technology

The invention relates to a functional resin tectorial membrane proppant and a preparation method thereof, and belongs to the technical field of oil-gas field development. The functional resin tectorial membrane proppant comprises aggregate and a resin film coated on the aggregate. Said resin film comprises organic silicon compounds of one or more active groups of amino, hydroxyl, carboxyl, alkoxyl and hydrosulphonyl. The side chain of the organic silicon compound is a hydrophobic group. The cured resin film has different wetting qualities for oil and water. The functional resin tectorial membrane proppant of the invention has a function of allowing the smooth permeation of oil gas and preventing water from penetrating through the proppant. Such a function improves the separation effect ofoil gas and water and reduces the oil production cost. The excellent hydrophobicity of the resin film facilitates the proppant to have excellent water resisting property and improves the crushing resistance of the proppant, so that the stream guidance effect is good for a long time.

The invention relates to the field of Chinese medicine preparation, in particular to a method for preparing tripterine nano structure lipid carrier containing traditional Chinese medicine monomer and application of the tripterine nano structure lipid carrier in preparation of transdermal drugs used for treating psoriasis, rheumatoid arthritis, skin cancer and breast cancer. The tripterine nano structure lipid carrier is characterized by comprising the following components in parts by weight: 1 part of tripterine, 5-100 parts of mixed lipid, 0.5-10 parts of phospholipid, 0.1-15 parts of poloxamer-188 and 0.5-10 parts of vitamin E and tocopherol polyethylene glycol succinate, wherein the mixed lipid is composed of solid lipid monoglycerine and liquid lipid octylic acid/caprin according to the weight ratio of 1: 0.1-10: 1. Tripterine is prepared into the nano structure lipid carrier, the tripterine nano structure lipid carrier in a semi-solid or liquid preparation form is applied in a transdermal way, bioavailability of the tripterine can be improved, toxic response of tripterine can be reduced, and the nano structure lipid carrier provided by the invention has great clinical application value in the improvement of the treatment effect of tripterine.

The invention discloses a preparation method of an amphoteric polyelectrolyte complex surface-modified polyamide reverse osmosis membrane. The preparation method comprises the steps: firstly, preparing an amphoteric cationic polymer by a free radical polymerization method, then preparing an amphoteric polyelectrolyte complex by an ionic crosslinking method, dispersing the amphoteric polyelectrolyte complex in an aqueous phase solution, and thus obtaining the amphoteric polyelectrolyte complex surface-modified polyamide reverse osmosis membrane through surface secondary interface polymerization. With utilization of good hydrophilicity, contamination resistance and a unique nanoparticle structure of the amphoteric polyelectrolyte complex, the water permeation flux and contamination resistance of the membrane are improved while the high interception rate of the polyamide membrane on an inorganic salt is kept. Under an operating pressure of 1.5 MPa at the temperature of 25 DEG C, the interception rate of the reverse osmosis membrane on NaCl is more than 98%, the water flux is greater than 30 L.m<-2>.h<-1>. Therefore, the prepared amphoteric polyelectrolyte complex surface-modified polyamide reverse osmosis membrane has high desalination rate, water permeability and contamination resistance.

The invention provides a nano composition with hair loss preventing, hair growing, hair fixing and hair blackening functions as well as a preparation method and application thereof, and relates to thetechnical field of cosmetics with special functions. The nano composition comprises diaminopyrimidine oxide, pyrrolidinyl diaminopyrimidine oxide, hair growing peptide, hair fixing peptide, hair blackening peptide, a cell penetrating agent, vitamin E, polydiethylene glycol succinate, phospholipid, cholesterol, polyhydric alcohol and water. The nano composition is good in transdermal performance,improves the adsorption capacity of a preparation on scalp, deeply permeates into hair follicles, can be retained in the hair follicles for a long time, can be maintained at an effective concentrationfor a long time, improves the bioavailability, reduces the use amount of active ingredients, and enables low-content and anti-hair-loss active matter to play an excellent anti-hair-loss effect.

A liquid-permeable nonwoven fibrous fabric which permits a viscous bodily fluid to pass therethrough. The liquid-permeable nonwoven fibrous fabric (1) comprises staple fibers (2) formed from a thermoplastic synthetic resin and disposed in the state of being fusion-bonded to one another. The front surface (3) thereof has ridges (6) and grooves (7), the ridges (6) and the grooves (7) extending in parallel with one another in the lengthwise direction (A) and being alternately arranged in the crosswise direction (B). The proportion of the height (t) from the back surface (4) of the nonwoven fibrous fabric (1) to the bottom (12) of each groove (7) to the height (T) from the back surface (4) to the top (11) of each ridge (6) is in the range of 40-55%. The front surface (3) includes fibers (2a) which are staple fibers (2) each extending between adjacent grooves (7) through the ridge (6) and which have been fusion-bonded to other staple fibers (2) in each of the grooves (7).

It is intended to while satisfactorily exerting the function as a second sheet, prevent 'sticking' by carrying out an embossing of surface sheet. There is provided a humor absorbent article comprising surface sheet (1), liquid permeable member (20) with humor permeability containing a fiber mass of cane and absorption element (AB) with humor retaining capability arranged in this order, wherein second surface-side sheet (10) is interposed between the surface sheet (1) and the liquid permeable member (20) with humor permeability in such a positional relationship that at least part thereof overlaps the liquid permeable member with humor permeability, and wherein the surface sheet (1) and the second surface-side sheet (10) are jointly embossed while the liquid permeable member (20) with humor permeability is not embossed.

The novel positively charged pro-drugs of ibuprofen in the general formula (I) ''Structure 1'' were designed and synthesized. The compounds of the general formula (I) ''Structure 1'' indicated above can be prepared from functional derivatives of ibuprofen, (for example acid halides or mixed anhydrides), by reaction with suitable alcohols, thiols, or amines. The positively charged amino groups of these pro-drugs not only largely increases the solubility of the drugs, but also bonds to the negative charge on the phosphate head group of membranes and pushes the pro-drug into the cytosol. The experiment results suggest that the pro-drug, diethylaminoethyl 2-(p-isobutylphenyl) propionate.AcOH, diffuses through human skin -250 times faster than ibuprofen itself and -125 times faster than ethyl 2-(p-isobutylphenyl) propionate. In plasma, more than 90% of these pro-drugs can change back to the drug in a few minutes. The prodrugs can be used medicinally in treating any ibuprofen-treatable conditions in humans or animals and be administered not only orally, but also transdermally for any kind of medical treatments and avoid most of the side effects of ibuprofen, most notably GI disturbances such as dyspepsia, gastroduodenal bleeding, gastric ulcerations, and gastritis. Controlled transdermal administration systems of the prodrug enable the ibuprofen to reach constantly optimal therapeutic blood levels to increase effectiveness and reduce the side effects of ibuprofen.

The invention is concerned with a kind of cataplasma for reducing swelling and ease pain and its preparation method, relating to active constitutent and matrix. The active constitutent is made of ledebouriella root, herba schizonepetae, asarum herb, Achyranthes bidentata Bl, chuanxiong rhizome, panicled swallowwort root, Rhizoma Curcumae, Ardisia crenata L, Fordia Cauliflora Hemsl, prickly ash, burreed tuber, cassia twig, dahurian angelica root, ichnocarpus loiganthus, auckandia root, fibraurea stem, acanthopanax bark, cape jasmine, eagle ood, bornanone and mentha camphor. The matrix relates to bond, emulsifier, humectant, penetration enhancer and pH moderator. This invention also relates to the component of matrix and the preparation method of cataplasma. It uses to cure wind dampness and bone ache, traumatic injury, inflammatory process of tissue of unknown origin and parotitis ache with definite effect in rapid and without side effect.

The present invention provides a medicine compound for glioma treatment, which comprises Temozolomide, the second part comprising the Borneo camphor with or without the Menthol. The weight ratio of the Temozolomide to the Borneo camphor or the Menthol is 1 till 50 to 2 till 100. The present invention also provides a preparation method for the agent or the compound agent. The medicine compound prescription provided in the present invention has properties of low taking dose, good therapy effect and little side effect.

The invention provides a nanoparticle vaccine preparation containing a recombinant hepatitis B surface antigen. The preparation comprises the following components: a core which is composed of human serum albumin, the recombinant hepatitis B surface antigen and sodium bicarbonate; an encapsulated layer which is a polylactic acid-polyglycolic acid segmented copolymer for encapsulating the core; an external layer which is composed of chitosan or mannan or a mixture thereof for coating. The preparation method comprises the following steps: (1) adding the recombinant hepatitis B surface antigen, the human serum albumin and sodium bicarbonate are added into a phosphate buffered solution containing polyvinyl alcohol to obtain an internal water phase; (2) dissolving the polylactic acid-polyglycolic acid segmented copolymer into an organic solvent for preparing an oil phase, adding the internal water phase obtained in the step (1) into the oil phase, and stirring at a high speed for forming a W/O primary emulsion; (3) adding the W/O primary emulsion into an external water phase solution containing polyvinyl alcohol, stirring at a high speed for forming a W/O/W complex emulsion, stirring at a low speed, carrying out a centrifugal washing, collecting nanoparticles, carrying out a vacuum freeze drying to obtain the finished product nanoparticle vaccine preparation containing the recombinant hepatitis B surface antigen.

The invention discloses a radioisotope labeled polypeptide developer of a targeted transferrin receptor and application of the radioisotope labeled polypeptide developer. The invention particularly discloses a 68Ga chelation reaction labeling method of two polypeptide precursors and application of the two polypeptide precursors as an imaging agent in positron emission tomography (PET) of a transferrin receptor overexpressed tumor. The radioisotope labeled product has radiochemical purity of more than 95% and good in-vivo stability, can be rapidly aggregated within 5 minutes at a tumor site, has obvious tumor muscle contrast, can realize clear imaging of tumor tissues and margins, and has a certain difference between pharmacokinetics and biodistribution due to structural modification of different linking groups, so that the compound can be used as a tumor-specific imaging agent of a targeted transferrin receptor.

The invention discloses a method for preparing thin-film-type artificial crystalline lens and the product prepared with this method. The invention employs normal physical or chemical method to coat the optical thin film on the surface of the artificial crystalline lens, to prepare reflection reducting coating artificial crystalline lens. The method controls the light passing through the artificial crystalline lens by controlling the thickness and layer number of the coating film, to make the light past possess a certain wavelength and intensity, through which can realizes purpose of improving the eyesight quality of the patient using artificial crystal lens.

The invention belongs to the field of flat plate luminescent devices, in particular to the field of organic electroluminescent devices, and relates to a method for improving the coupling luminous efficiency of the flat plate luminescent device, in particular to a method for improving the coupling luminous efficiency of the flat plate luminescent device by preparing a nano-cone array on the surface of a substrate of the organic electroluminescent device through direct etching. In the method, the coupling luminous efficiency of a white organic electroluminescent device is improved by 1.4 times by using excellent broad band anti-reflection performance of the nano-cone array. Simultaneously, the ratio of the luminous intensity of one apparatus to that of another apparatus is increased by 60 times when an angle is up to 70 degrees.

The invention provides a solid preparation containing capsaicin.The solid preparation is prepared from capsaicin, menthol, a coating layer and auxiliary materials, wherein the coating layer is a double-layer coating and consists of an isolation coating layer and a slow release coating layer.The auxiliary materials include a filling agent and a lubricant. The solid preparation containing the capsaicin applies the menthol as a carrier for the first time, so that the in-water solubility of the capsaicin in the preparation is improved from 0.011 micro-g/mL to 40 micro-g/mL and is far higher than that ofJapan's commercially availablecapsaicin tablets (2.6micro-g/mL). Therefore, the taking dosage of a final product can be reduced, the irritation of the capsaicin to the gastrointestinal tract is reduced. In addition, double-layer coating design is conducted on the final product, the stability of the product is also ensured while release is controlled. Furthermore,attractive, complete and smooth slow-release coatings having a slow-release effect can be achieved without any plasticizer or anti-sticking agent.

The invention discloses muscone derivatives, a preparation method and an application thereof, belonging to the technical field of biological materials. The muscone derivatives have a structure as represented by formula (A) and (B) and pharmaceutically acceptable salts of that above structures. The invention also discloses the preparation method of the above muscone derivatives and the applicationthereof. Firstly, the muscone derivative of the present invention is easy to form hydrochloride and can improve the solubility thereof. Secondly, the active group amino group on the structure can be connected to the carrier material through chemical reaction. Thirdly, it can be modified on the surface of the carrier material as a target head, and only a small amount dosage is used for modificationto promote the drug-loaded nano-delivery system into the brain. Fourthly, that muscone derivativecan be used for preparing the muscone phospholipid compound, and the muscone phospholipid compound hasgood biocompatibility, has the advantage of promoting the delivery system to penetrate the blood-brain barrier, and can be used for preparing the brain-targeted delivery drug.

The invention discloses a prodrug compound represented by a structure formula 1, a composition or a preparation thereof, and a use of the prodrug compound in preparation of drugs for treatment of treatable conditions of non-steroidal anti-inflammation drugs in human or animals. The prodrug compound has a more rapid skin penetration speed compared with the corresponding parent drug. The invention further discloses a transdermal treatment application system, which at least contains one of the prodrug compound represented by the structure formula 1, or the composition, or the preparation.

The invention relates to application of amphipathic pegylated retinoic acid and a self-assembly micelle thereof in drug delivery. An amphipathic prodrug block takes polyethylene glycol as a hydrophilic end and is bonded with hydrophobic retinoic acid through an ester bond, so that an AB type amphipathic prodrug block is obtained. The polymer has effects of potential treatment for leukemia and prolonging the half life of drug, has a higher drug loading rate, and effectively increases gastrointestinal mucosa permeability so as to increase the oral bioavailability. The pegylated prodrug is self-assembled to form the micelle in an aqueous medium, and the micelle can be used as a storage cavern of the indissolvable drug retinoic acid to slowly release retinoic acid. The micelle is good in safety, can be used for oral administration, and has a great market application prospect.

The invention relates to the field of traditional Chinese medicines, and provides a Chinese and western medicine external patch for treating scapulohumeral periarthritis. An emplastrum is prepared from the following active ingredients and auxiliary materials in parts by weight; the active ingredients comprise 0.1 to 0.3 part of moschus, 100 to 200 parts of radix notoginseng, 50 to 100 parts of safflower, 50 to 100 parts of radix salviae miltiorrhizae, 1.2 to 1.8 parts of boric acid, 1.2 to 1.8 parts of root of cinnamomum camphora, 3 to 6 parts of dragon's blood, 1 to 5 parts of urea, 10 to 20 parts of extractum belladonnae liquidum, 0.5 to 1.5 parts of diphenhydramine hydrochloride, and 1 to 3 parts of procaine hydrochloride; the auxiliary materials comprise 280 to 350 parts of rubber, 120 to 160 parts of rosin, 350 to 450 parts of zinc oxide, 30 to 50 parts of lanolin, and 10 to 20 parts of vaseline. The emplastrum has the advantages that the effects of activating blood circulation and dredging collaterals, and sterilizing bacteria and relieving pain are realized, the emplastrum quickly takes effect, the curative effect is obvious, any side effect is avoided, the safety is high, the convenience in use is realized, and the like; the effect of treating the scapulohumeral periarthritis is obvious, and the curative rate is 92%.

The invention discloses an oral medicament or health care food for treating melancholia with acting mechanism after being made into multiple-target drone receptor with raw materials of ginsenoside (Rg1+Rb1), glycyrrhizic acid and Chinese date cAMP. According to the experiment to prove, the medicament composition of the invention can obviously reduce the small mouse suspension tail dead time and body temperature descend induced by reserpine; obviously improve the rat horizontal and vertical movement increase and rat learning and memory function abatement caused by buibus olfactorius damage; meanwhile can improve saccharose drinking water amount decrease and body weight descend caused by unpredictable long term stress stimulus, can improve the rat horizontal and vertical movement decrease and obvious increase of the NE and 5-HT content in the rat cerebral cortex caused by unpredictable long term stress stimulus. The experiment result proves that the medicament has remarkable anti-melancholia efficacy, comparing to the current medicament Paroxetine for treating the melancholia in prior art.

The invention belongs to the technical field of skincare products and provides long-acting moisturizing gel with deep penetration and a preparation method. The preparation method comprises the following steps: adsorbing hyaluronic acid with silicon dioxide aerogel and chitosan, further loading in hollow holes of a polylactic acid hollow fiber, and further mixing with azone, menthol, an organic amine, stearic acid, monostearin, carbomer resin, methylcellulose, concentrated glycyrrhizic acid powder and deionized water, thereby obtaining the moisturizing gel. Compared with a conventional method,the moisturizing gel provided by the invention has the advantages that by virtue of a micro puncturing function of the polylactic acid fiber upon skin, the carried hyaluronic acid is promoted to penetrate through epidermis, in addition, under the actions of the azone, the menthol and the organic amine, skin expansion is promoted, and further the penetration of the hyaluronic acid is promoted, so that deep layer water replenishing and moisturizing can be achieved; and in addition, as the hyaluronic acid is carried inside the hollow fiber, a slow release function is achieved, and long-acting moisturizing can be achieved.

The invention belongs to the field of traditional Chinese medicines, and discloses massage medicinal oil for relieving back myofascitis and a preparation method thereof. The massage medicinal oil is prepared from the following active ingredients: Ningpo yam rhizome, root of Kwangsi schefflera, common clubmoss herb, all grass of serrulate clearweed, marsdenia sinensis, axillary choerospondias fruit, turtle shell, cornu cervi pantotrichum, Szechuan lovage rhizome, Himalayan teasel root, common jasminorange, balsamiferou blumea herb, root of doubleteeth pubescent angelica, prince's-feather herb, dahurian angelica root, lunate peltate sundew herb, safflower, myrrh, forbes wildginger herb, prepared common monkshood daughter root, combined spicebush root, honey-wax, olive oil, coconut oil, galam butter, laurocapram, chamomile essential oil and jasmine essential oil. The massage medicinal oil disclosed by the invention is mild in medicine property and fresh in smell, has the effects of relaxing and activating tendons, promoting flow of qi and blood circulation, softening and resolving hard masses, dispelling wind and dampness, and dispelling cold to relieve pain, and can repair damaged fascia, clear blood stasis and relieve muscle spasm, thereby greatly relieving or even cure back myofascitis from outside.

The invention discloses power generation glass for photovoltaic building integration and a preparation method of the power generation glass. The power generation glass sequentially comprises an anti-reflection film coating, a first glass substrate layer, a first adhesive film, a second glass substrate layer, a transparent conductive film, an absorption layer, a back contact layer, a back electrodelayer, a second adhesive film and a back plate glass layer from bottom to top; the absorption layer is made of cadmium telluride; and the heat insulation capacity and the sound insulation performanceof the power generation glass are improved, and the maximum power stabilization time of the power generation glass is shortened.

The invention discloses a transdermal delivery preparation. The transdermal preparation comprises a transdermal preparation component (a), wherein the component (a) is a cationic polymer modified by afluorine-containing compound; the cationic polymer modified by the fluorine-containing compound is fluorinated chitosan, the fluorine-containing compound is covalently connected to a main chain of the chitosan, the molecular weight range of the chitosan is 1000-5000000, the deacetylation degree of the chitosan is not less than 55%, and the viscosity range of the chitosan is 25-1000 centipoises. The cationic polymer modified by the fluorine-containing compound has the advantages of being capable of being universally combined with various medicines, promoting medicine absorption, improving thebioavailability of the medicines and reducing toxicity, good in effect, very wide in application and huge in commercial value, and the cationic polymer modified by the fluorine-containing compound iseasy to produce and has a commercial foundation.

The invention relates to a water-soluble ibuprofen prodrug with high skin penetration rate and positive charges. The invention discloses the application of a compound shown in a structural formula 1 to preparation of a medicament suitable for transdermal delivery and for treating the conditions that can be treated by ibuprofen, and the application of the compound shown in the structural formula 1 to preparation of an aerosol medicament for treating asthma. The invention also discloses the application of a pharmaceutical composition for transdermal delivery and containing the compound shown in the structural formula 1, the application thereof to preparation of a medicament suitable for transdermal delivery and for treating the conditions that can be treated by ibuprofen, and the application of the pharmaceutical composition to preparation of an aerosol medicament for treating asthma. The invention also discloses a transdermal therapeutic system, which comprises the compound shown in the structural formula 1 or its composition, and a usage method of the transdermal therapeutic system.