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Nano composition with hair loss preventing, hair growing, hair fixing and hair blackening functions as well as preparation method and application thereof

A nano-composition, a technology for preventing hair loss and regrowth, which are applied to a nano-composition with black hair function and its preparation, fix hair, have the field of preventing hair loss and regrowth, and can solve the problems of poor use effect, difficult adsorption, and insufficient efficacy.

Pending Publication Date: 2021-03-19
WUHAN BEST CARRIER NANO TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Chinese invention patent CN201910540301.6 discloses a nanocomposite and its preparation method and application, but there are still defects and deficiencies: because it is an ordinary nanovesicle that is not specifically positively charged during the production process, it is difficult to adsorb On the negatively charged human hair and scalp, thereby reducing the probability of preparation adsorption, and also reducing the probability of penetrating into the hair follicle target through the scalp; secondly, it only involves hair growth and hair fixing effects, not black hair effects, The efficacy is not comprehensive enough; again, it focuses on containing two biological peptides, hair-fixing root peptide and hair growth-promoting peptide, but it does not involve cell biology experiments on hair fixing and hair growth; finally, its patent contains diaminopyrimidine oxide , but the effect is poor

Method used

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  • Nano composition with hair loss preventing, hair growing, hair fixing and hair blackening functions as well as preparation method and application thereof
  • Nano composition with hair loss preventing, hair growing, hair fixing and hair blackening functions as well as preparation method and application thereof
  • Nano composition with hair loss preventing, hair growing, hair fixing and hair blackening functions as well as preparation method and application thereof

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preparation example Construction

[0059] The present invention also provides a preparation method of the nano composition described in the above technical scheme, comprising the following steps:

[0060] (1) The fat-soluble components in the phospholipid, cholesterol, cell penetrating agent, polyol, diaminopyrimidine oxide, pyrrolidinyl diaminopyrimidine oxide and hair growth peptide, hair-fixing peptide, black hair peptide are mixed, Dissolving at 20-60°C to obtain the first mixture;

[0061] (2) Mix the water-soluble ingredients in the hair growth peptide, hair-fixing peptide, and black hair peptide, polyhydric alcohol, vitamin E polyethylene glycol succinate and water, and dissolve at 20-60° C. to obtain the second mixture;

[0062] (3) adding the second mixture obtained in step (2) dropwise to the first mixture obtained in step (1), and then performing shear emulsification treatment to obtain a micron-scale dispersion;

[0063] (4) The micron-scale dispersion obtained in the step (3) is subjected to high-...

Embodiment 1

[0075] 5% soybean lecithin, 1% hydrogenated soybean lecithin, 0.5% cholesterol, 2% hydroxypropyl trimethyl ammonium chloride hydrolyzed soybean protein, 1% soybean oil trimethyl ammonium chloride, 20% propylene glycol, 5 % 1,2-pentanediol, 4% diaminopyrimidine oxide, 2% pyrrolidinyl diaminopyrimidine oxide and 0.1% palmitoyl hexapeptide-25 were mixed, heated and dissolved in a 35°C water bath to obtain the first mixture;

[0076] 0.1% Octapeptide-2, 0.1% Acetyl Tetrapeptide-3, 0.1% Biotin Tripeptide-1, 0.2% Acetyl Hexapeptide-1, 5% Glycerin and 3% Vitamin E Polyethylene Glycol Succinate Add it into 50.9% purified water, heat and dissolve in a water bath at 35°C to obtain the second mixture;

[0077] Add the second mixture dropwise to the first mixture and keep stirring. After the mixing is completed, high-speed shear emulsification is carried out at a speed of 5000 rpm for 8 minutes to obtain a micron-sized dispersion;

[0078] The micron-scale dispersion was subjected to hig...

Embodiment 2

[0081] 7% egg yolk lecithin, 1% cholesterol, 4% hydroxypropyltrimethylammonium chloride hydrolyzed soybean protein, 2% polyquaternium-51, 15% propylene glycol, 15% 1,2-hexanediol, 5 % diaminopyrimidine oxide, 2.5% pyrrolidinyl diaminopyrimidine oxide and 0.05% palmitoyl tripeptide-1 were mixed, heated and dissolved in a water bath at 40°C to obtain the first mixture;

[0082] Add 0.05% myristoyl pentapeptide-17, 0.05% myristoyl pentapeptide-16, 0.05% decapeptide-10, 0.1% copper peptide, 5% butanediol and 4% vitamin E polyethylene glycol succinate into 39.2% purified water, heated and dissolved in a 40°C water bath to obtain the second mixture;

[0083] Add the second mixture dropwise to the first mixture and keep stirring. After the mixing is completed, perform high-speed shear emulsification at a speed of 7000 rpm for 6 minutes to obtain a micron-sized dispersion;

[0084] The micron-scale dispersion was subjected to high-pressure homogenization treatment at a pressure of 80...

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Abstract

The invention provides a nano composition with hair loss preventing, hair growing, hair fixing and hair blackening functions as well as a preparation method and application thereof, and relates to thetechnical field of cosmetics with special functions. The nano composition comprises diaminopyrimidine oxide, pyrrolidinyl diaminopyrimidine oxide, hair growing peptide, hair fixing peptide, hair blackening peptide, a cell penetrating agent, vitamin E, polydiethylene glycol succinate, phospholipid, cholesterol, polyhydric alcohol and water. The nano composition is good in transdermal performance,improves the adsorption capacity of a preparation on scalp, deeply permeates into hair follicles, can be retained in the hair follicles for a long time, can be maintained at an effective concentrationfor a long time, improves the bioavailability, reduces the use amount of active ingredients, and enables low-content and anti-hair-loss active matter to play an excellent anti-hair-loss effect.

Description

technical field [0001] The invention relates to the technical field of special functional cosmetics, in particular to a nanocomposite with the functions of preventing hair loss, hair growth, hair blackening and its preparation method and application. Background technique [0002] As social competition becomes more and more fierce, people's work and life pressures increase, mental stress, staying up late, etc. lead to an increase in the proportion of people with hair loss and gray hair in modern society, and the trend of younger people is becoming more and more obvious. [0003] Among them, androgenetic alopecia (AGA) is the most common alopecia disease clinically, accounting for about 90% of alopecia. At present, the commonly used chemical hair growth agents for the treatment of androgenetic alopecia include minoxidil, finasteride, etc., but the side effects are obvious. Minoxidil can cause scalp dryness, dandruff, scalp erythema, inflammation, irritation, etc. And it will ...

Claims

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Application Information

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IPC IPC(8): A61K8/86A61K8/34A61K8/49A61K8/55A61K8/63A61K8/64A61K8/73A61K8/81A61P17/14A61Q5/00A61Q7/00
CPCA61K8/4953A61K8/86A61K8/553A61K8/64A61K8/645A61K8/73A61K8/345A61K8/817A61K8/63A61Q5/00A61Q7/00A61P17/14A61K2800/5922A61K2800/413
Inventor 刘卫沈慧慧陈家玲王曦罗丹陈丹洪延涵
Owner WUHAN BEST CARRIER NANO TECH
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