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Transfersome preparation for preventing and/or treating alopecia and preparation method and application thereof

A kind of technology of alopecia and transfer body, applied in the field of pharmaceutical preparations, can solve the problems of inability to act on the deep structure of hair follicles, limit the therapeutic effect of alopecia, and difficult to penetrate the cuticle of the skin, so as to achieve excellent anti-hair loss effect and promote the penetration of cutin layer, good stability

Active Publication Date: 2021-09-24
CHENGDU BRILLIANT PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the preparation described in this application is a solution preparation, and its permeability to the skin is limited, which makes it difficult for the dermosterone-17α-propionate in the preparation to penetrate the stratum corneum of the skin, let alone act on the deep structure of the hair follicle, Limits its therapeutic effect on alopecia
At present, there is no report of a transfer body with good transdermal performance, which can penetrate deeply into the hair follicle, and at the same time can make dermatosterone-17α-propionate stay in the hair follicle for a long time to exert an excellent anti-hair loss effect

Method used

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  • Transfersome preparation for preventing and/or treating alopecia and preparation method and application thereof
  • Transfersome preparation for preventing and/or treating alopecia and preparation method and application thereof
  • Transfersome preparation for preventing and/or treating alopecia and preparation method and application thereof

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0068] Embodiment 1 Preparation of transfer body preparation (F1) of the present invention

[0069] The preparation method (film hydration method) is as follows:

[0070] (1) Add corticosterone-17α-propionate, Span80, and EPC to 12 mL of ethanol, and use a water-bath sonicator to sonicate for 5 minutes (ultrasonic power: 40 kHz) to ensure that all components are completely dissolved to obtain a mixture; in 12 mL of the mixture, The concentration of Span80 is 5% mg / mL, and the concentration of EPC is 95% mg / mL;

[0071] (2) Use a rotary evaporator (rotating speed 250rpm) to evaporate the ethanol under reduced pressure at 60° C., and obtain a continuous lipid film after the ethanol is completely evaporated;

[0072] (3) adding the lipid film to phosphate buffer (pH7.4) and ultrasonically treating it for 10 minutes to obtain a hydrated preparation, and then standing the hydrated preparation at room temperature for 30 minutes to obtain a primary medicinal solution;

[0073] (4) ...

Embodiment 2

[0075] Embodiment 2 Preparation of transfer body preparation (F2) of the present invention

[0076] Preparation method: refer to the preparation method of Example 1 to prepare the transfer body preparation of the present invention, referred to as F2, the difference is only that the lipid and edge activator types are replaced according to Table 1, and the corticosterone-17α-propane is controlled according to Table 1 Feed concentration of esters, lipids, edge activators.

Embodiment 3

[0077] Embodiment 3 Preparation of transfer body preparation (F3) of the present invention

[0078] Preparation method: refer to the preparation method of Example 1 to prepare the transfer body preparation of the present invention, referred to as F3, the only difference is that the lipid and edge activator types are replaced according to Table 1, and the corticosterone-17α-propane is controlled according to Table 1 Feed concentration of esters, lipids, edge activators.

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Abstract

The invention provides a transfersome preparation for preventing and / or treating alopecia and a preparation method and application thereof and belongs to the field of pharmaceutical preparations. Experimental results show that the transfersome preparation provided by the invention is good in transdermal performance and high in scalp adsorption capacity, can deeply penetrate into hair follicles and stay in the hair follicles for a long time, and can maintain an effective concentration of medicines for a long time, the bioavailability is improved, the use amount of active ingredients is reduced, and the low-content active ingredients can exert an excellent anti-alopecia effect. The preparation method of the transfersome preparation provided by the invention is simple, conditions are mild, and the transfersome preparation has a good application prospect in preparation of drugs or cosmetics for preventing and / or treating the alopecia (especially androgen-derived alopecia).

Description

technical field [0001] The invention belongs to the field of pharmaceutical preparations, and in particular relates to a transfer body preparation for preventing and / or treating alopecia, its preparation method and application. Background technique [0002] As social competition becomes more and more fierce, people's work and life pressures increase, mental stress, staying up late, etc. lead to an increase in the proportion of people with hair loss and gray hair in modern society, and the trend of younger people is becoming more and more obvious. Alopecia includes androgenetic alopecia, telogen effluvium, alopecia areata, lupus alopecia, anagen hair loss syndrome, etc. [0003] Androgenetic alopecia (abbreviated AGA), also known as androgenetic alopecia or seborrheic alopecia, is the most common type of hair loss clinically. A large amount of evidence shows that AGA has obvious genetic tendency between parents and offspring, and it occurs in both sexes. Studies have shown ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K45/00A61K31/573A61K47/24A61K47/28A61P5/28A61P17/14A61K8/63A61K8/55A61Q7/00
CPCA61K45/00A61K31/573A61K47/24A61K47/28A61P5/28A61P17/14A61K8/63A61K8/553A61Q7/00
Inventor 黄丹曾洋阳秀平梁臻黄浩喜苏忠海
Owner CHENGDU BRILLIANT PHARMA CO LTD
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